A5055188969- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Gut microbiota and health
- COVID-19 and Mental Health
- Adolescent and Pediatric Healthcare
- Eating Disorders and Behaviors
- Diet and metabolism studies
- Digital Mental Health Interventions
- Stress Responses and Cortisol
- Electrolyte and hormonal disorders
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Vitamin D Research Studies
- Sleep and related disorders
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Circadian rhythm and melatonin
- Mental Health Research Topics
- Toxoplasma gondii Research Studies
- Personality Disorders and Psychopathology
- Infant Health and Development
- Obsessive-Compulsive Spectrum Disorders
- Cytomegalovirus and herpesvirus research
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological disorders and treatments
Medical University of Graz
2015-2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2018
There is evidence that the gut microbiota plays a major role in pathogenesis of diseases central nervous system through gut-brain axis. The aim present study was to analyze composition bipolar disorder (BD) and its relation inflammation, serum lipids, oxidative stress, tryptophan (TRP)/kynurenine (KYN) levels, anthropometric measurements parameters metabolic syndrome. Further, microbial community differences individuals with BD compared healthy controls (HC) were explored.In this...
Gut microbiota are suspected to affect brain functions and behavior as well lowering inflammation status. Therefore, an effect on depression has already been suggested by recent research. The aim of this randomized double-blind controlled trial was evaluate the probiotic treatment in depressed individuals. Within inpatient care, 82 currently individuals were randomly assigned either receive a multistrain plus biotin or placebo for 28 days. Clinical symptoms gut microbiome analyzed at begin...
Introduction Bipolar disorder (BD) is a chronic psychiatric disease which can take most different and unpredictable courses. It accompanied by unspecific brainstructural changes cognitive decline. The neurobiological underpinnings of these processes are still unclear. Emerging evidence suggests that tryptophan catabolites (TRYCATs), involve all metabolites towards the kynurenine (KYN) branch, involved in etiology as well course BD. They proposed to be mediators immune-inflammation...
<b><i>Introduction:</i></b> Cognitive dysfunction is prevalent in depressive as well manic episodes individuals with Bipolar Disorder (BD). Even more, after symptom remission, many BD experience persisting cognitive impairment also euthymic periods, leading to high illness burden and low quality of life. According a recent research animals healthy humans, microbiota may influence processes via the brain-gut axis. A strategy examine role different diseases intake...
Major depressive disorder (MDD) is a prevalent disease, in which one third of sufferers do not respond to antidepressants. Probiotics have the potential be well-tolerated and cost-efficient treatment options. However, molecular pathways their effects are fully elucidated yet. Based on previous literature, we assume that probiotics can positively influence inflammatory mechanisms. We aimed at analyzing gene expression inflammation genes as part randomized, placebo-controlled, multispecies...
The clock gene ARNTL is associated with the transcription activation of monoamine oxidase A according to previous literature. Thus, we hypothesised that methylation may differ between bipolar disorder (BD) and controls.The status one CpG island covering first exon (PS2) site in 5' region (cg05733463) were analysed patients BD (n = 151) versus controls 66). Methylation analysis was performed by bisulphite-conversion DNA from fasting blood EpiTect Bisulfite Kit, PCR pyrosequencing. Analysis...
Background: Metabolic syndrome (MetS) is more prevalent in individuals with bipolar disorder and has a negative impact on cognition, particular executive function, which already impaired compared to healthy controls. Methods: In cross-sectional study, we 148 euthymic patients 117 controls cognitive function depending the diagnosis of MetS. A neuropsychological test battery was used including Trail Making Test A/B, Stroop Color Word Interference Test, d2 Attention Revised, California Verbal...
Investigation on specific biomarkers for diagnostic or prognostic usage in mental diseases and especially bipolar disorder BD seems to be one outstanding field current research. Serum neurofilament light (sNfL), a marker neuro-axonal injury, is increased various acute chronic neurological disorders, but also neuro-psychiatric conditions, including affective disorders. The aim of our study was determine potential relation between neuron-specific like sNfL different clinical states BD....
Background Bipolar disorder is associated with impairments in cognition and psychosocial functioning. Although these occur frequently, often persist during euthymic times, worsen quality of life, the impact cognitive abilities on functioning has not yet been fully elucidated. Methods The current study investigated effects domains (attention/psychomotor speed, verbal learning/memory, executive function) cross-sectionally. Data from 210 individuals bipolar [101 female, 109 male; M (age) =...
The gut–brain axis plays a role in major depressive disorder (MDD). Gut-bacterial metabolites are suspected to reduce low-grade inflammation and influence brain function. Nevertheless, randomized, placebo-controlled probiotic intervention studies investigating metabolomic changes patients with MDD scarce. PROVIT study (registered at clinicaltrials.com NCT03300440) aims close this scientific gap. was conducted as single-center, double-blind, multispecies individuals (n = 57). In addition...
Owing to the heterogenic picture of bipolar disorder, it takes approximately 8.8 years reach a correct diagnosis. Early recognition and early intervention might not only increase quality life, but also life expectancy as whole in individuals with disorder. Therefore, we hypothesize that implementing machine learning techniques can be used support diagnostic process disorder minimize misdiagnosis rates.
Matrix metallopeptidase 9 (MMP9) and soluble intercellular adhesion molecule 1 (sICAM-1) are both involved in the restructuring of connective tissues. Evidence also implicates MMP9 sICAM cardiovascular neoplastic diseases, where blood levels may be a marker disease severity or prognosis. In individuals with bipolar disorder (BD), higher risk for illness has been extensively reported.The aim this investigation was to measure compare peripheral serum adults euthymic BD healthy controls (HC)....
Immune-mediated inflammatory processes and oxidative stress are involved in the aetiopathogenesis of bipolar disorder (BD) weight-associated comorbidities. Tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) along kynurenine axis concomitant with a pro-inflammatory state was found to be more active BD, associated overweight/obesity. This study aimed investigate tryptophan metabolism BD compared controls (C), stratified by weight classes, longitudinal setting, dependent on...
The COVID-19 pandemic affects both mentally healthy and ill individuals. Individuals with bipolar disorder (BD) constitute an especially vulnerable group. A multicentric online study was conducted in Austria, Denmark, Germany after the first lockdown phase 2020. In total, 117 controls (HC) were matched according to age sex individuals BD. survey included Brief Symptom Inventory-18, Beck Depression Inventory-2, Pittsburgh Sleep Quality Index, a self-constructed questionnaire assessing fears,...
Objectives: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might an association between adipokines neuropsychiatric core features BD such as mood disturbances cognitive deficits.Methods: In this investigation, fasting blood samples from 120 individuals with (75 euthymic 45 mild depressive symptoms) 68 control subjects were...
The importance of the microbiome for psychological well-being has gained rising interest in last decade. A strategy to examine role different diseases is intake supplements that modulate gut microbiome. Despite promising results animal studies, research humans sparse date and especially individuals with psychiatric disorders almost missing. current report ProbioBIP-one pilot study aims at describing general effects probiotic OMNi-BiOTiC Stress repair® on parameters as well gastrointestinal...
Altered levels of acute-phase proteins are often described in different conditions BD. Nevertheless, data on the association between lithium treatment and inflammatory markers long-term course BD still missing. The aim study was to examine concerning treatment, chronic processes symptom progression. Furthermore, duration hsCRP explored.267 individuals (males= 139, females= 128) with were included. Duration as well progression, defined increase severity symptoms, number episodes a year within...
Objectives: An important aspect of bipolar disorder (BD) research is the identification biomarkers pertaining to somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as an individual's state, given their influence on protein synthesis gluconeogenesis inhibition.Methods: BCAA levels 141 euthymic/subsyndromal individuals with BD matched healthy controls (HC) were analysed by high-pressure lipid chromatography correlated...
Hitherto literature indicates that mood stabilizers exert variable effects on oxidative and antioxidative systems, which are involved in the pathogenesis of Bipolar Disorder. Herein we primarily sought to characterize markers peripheral stress during euthymia adults with Disorder under current intake different (lithium, anticonvulsants atypical antipsychotics/AAPs).Peripheral parameters (TBARS/Thiobarbituric acid-reactive-substances, MDA/ malondialdehyde carbonyl proteins) (SOD/Cu/Zn...
Obesity and weight gain in bipolar disorder (BD) have multifactorial underlying causes such as medication side effects, atypical depressive symptomatology, genetic variants, disturbances the neuro-endocrinal system. Therefore, we aim to explore associations between food craving (FC), clinical parameters, psychotropic medication, appetite-related hormones. In this cross-sectional investigation, 139 individuals with BD 93 healthy controls (HC) completed inventory (FCI). addition, blood samples...