A5011012269- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Clinical practice guidelines implementation
- Cerebrovascular and genetic disorders
- MRI in cancer diagnosis
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Retinal and Optic Conditions
- Folate and B Vitamins Research
- Patient Satisfaction in Healthcare
- COVID-19 and healthcare impacts
- Pharmacological Effects and Toxicity Studies
- Patient-Provider Communication in Healthcare
- Epilepsy research and treatment
Radboud University Nijmegen
2011-2025
Catharina Ziekenhuis
2021-2025
Radboud University Medical Center
2008-2019
University Medical Center
2019
Ablynx (Belgium)
2018
University of Duisburg-Essen
2016-2017
University of Cambridge
2016-2017
Erwin L. Hahn Institute for Magnetic Resonance Imaging
2016-2017
Institut des Sciences Cognitives Marc Jeannerod
2017
Amphia Ziekenhuis
2016
Cigarette smoking doubles the risk of dementia and Alzheimer's disease. Various pathophysiological pathways have been proposed to cause such a cognitive decline, but exact mechanisms remain unclear. Smoking may affect microstructural integrity cerebral white matter. Diffusion tensor imaging is known be sensitive for changes in We therefore cross-sectionally studied relation between behaviour (never, former, current) diffusion parameters both normal-appearing matter lesions as well...
<h3>Objective:</h3> To investigate the temporal dynamics of cerebral small vessel disease (SVD) by 3 consecutive assessments over a period 9 years, distinguishing progression from regression. <h3>Methods:</h3> Changes in SVD markers 276 participants Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) cohort were assessed at time points years. We white matter hyperintensities (WMH) volume semiautomatic segmentation rated lacunes microbleeds manually....
To examine whether structural network connectivity at baseline predicts incident all-cause dementia in a prospective hospital-based cohort of elderly participants with MRI evidence small vessel disease (SVD).A total 436 from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC), without cerebral SVD, were included 2006. During follow-up (2011-2012), was diagnosed. The constructed diffusion tensor imaging followed by deterministic tractography measures...
White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and associated with cognitive decline the development dementia. Yet, temporal dynamics conversion normal-appearing white (NAWM) into WMH remains unknown. We examined whether when progression was preceded by changes in fluid-attenuated inversion recovery diffusion tensor imaging values, thereby taking account differences between participants mild versus severe baseline WMH.From 266 RUN DMC study (Radboud...
<b>Background: </b> Subjective cognitive failures (SCF) and subjective memory (SMF) have been reported to be an early predictor of Alzheimer disease (AD) attributed white matter lesions (WML). Since AD is characterized by hippocampal degeneration, it surprising that its relation with atrophy has investigated only sparsely. Previous studies on this are rare, limited in sample size, did not adjust for WML. <b>Objective: To determine the between SCF volume strata objective performance among...
The relation between progression of cerebral small vessel disease (SVD) and gait decline is uncertain, diffusion tensor imaging (DTI) studies on are lacking. We therefore investigated the longitudinal associations (micro) structural brain changes in SVD using DTI. 275 participants were included from Radboud University Nijmegen Diffusion Magnetic resonance Cohort (RUN DMC), a prospective cohort with aged 50-85 years. Gait (using GAITRite) magnetic measures assessed during baseline (2006-2007)...
<h3>Importance</h3> Gait and cognition have been related to mortality in population-based studies. This association is possibly mediated by cerebral small vessel disease (SVD), which has associated with as well. It unknown factors can predict individuals SVD. Identification of high-risk patients may provide insight into that reflect their vital health status. <h3>Objectives</h3> To assess SVD identify potential clinical and/or imaging mortality. <h3>Design, Setting, Participants</h3> A...
The relationship between cerebral small vessel disease (SVD) and dementia has been studied without considering white matter (WM) volume, the microstructural integrity of WM surrounding SVD, grey (GM).We prospectively investigated these structures risk dementia, formed a prediction model to investigate which characteristics (macro- or microstructural) explained most variance.The RUN DMC study is prospective cohort among 503 non-demented participants with an age 50 85 years at baseline,...
Objectives To investigate whether longitudinal structural network efficiency is associated with cognitive decline and baseline predicts mortality in cerebral small vessel disease (SVD). Methods A prospective, single-centre cohort consisting of 277 non-demented individuals SVD was conducted. In 2011 2015, all participants were scanned MRI underwent neuropsychological assessment. We computed properties using graph theory from probabilistic tractography calculated changes psychomotor speed...
To promote shared decision-making (SDM) during discharge planning of patients with stroke, a patient decision aid (PtDA) was implemented in seven Dutch hospitals. This mixed-methods process evaluation assessed: 1) PtDA use, 2) the SDM process, 3) facilitators and barriers influencing health care professional (HCP) adoption PtDA, 4) HCP experiences PtDA. Rates use were derived from hospital registries log data. levels consultations quantitatively assessed using OPTION-5 (score range 0-100);...
White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals SVD. We hypothesize that WMH might exert their effect on indirectly by affecting remote brain structures such as hippocampus. investigated temporal interactions between WMH, hippocampal atrophy older adults Five hundred three participants RUNDMC study...
To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role origin SVD markers on MRI.We included 503 from Radboud University Nijmegen Diffusion Tensor Magnetic Resonance Imaging Cohort (RUN DMC) study (mean age 65.6 years [SD 8.8], 56.5% male) 1.5T MRI 2006 and, if available, follow-up 2011 2015. We screened DWI scans (n = 1,152) for DWI+ lesions, assessed lesion evolution...
Introduction: Cerebral small vessel disease is one of the most important risk factors for dementia, and has been related to hippocampal atrophy, which among first observed changes on conventional MRI in patients with dementia.However, these volumetric might be preceded by loss microstructural integrity hippocampus not sensitive enough.Therefore, we investigated relation between diffusion parameters incident using tensor imaging, independent volume.Methods: The RUNDMC study a prospective 503...
Traditional markers of cerebral small vessel disease (SVD) are related to cognition and cognitive decline, but this relation is weak. Therefore other factors may determine the transition from intact performance such as damage white matter at microstructural level. Little known about association between integrity changes in cognition. In study we investigated baseline change function.503 participants RUN DMC with SVD without dementia, 398 whom (79.1%) underwent repeated testing follow-up, a...
Cerebral small vessel disease (SVD) is a frequent pathology in aging and contributor to the development of dementia. Plasma Aβ (amyloid β) levels may be useful as early biomarker, but role plasma SVD remains elucidated. We investigated association with severity progression markers.We studied 487 participants from RUN DMC study (Radboud University Nijmegen Diffusion Tensor Magnetic Resonance Imaging Cohort) whom 258 underwent 3 MRI assessments during 9 years. determined baseline Aβ38, Aβ40,...
Cerebral small vessel disease (SVD) is considered the most important vascular contributor to development of cognitive impairment and dementia. There increasing awareness that SVD exerts its clinical effects by disrupting white matter connections, predominantly connections between rich club nodes, a set highly connected interconnected regions. Here we examined progression disturbances in organization older adults with their associations conventional markers decline. We additionally...
The frequency of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) varies the current literature, and risk factors are unknown. We assessed incidence, factors, outcomes acute hospitalized COVID-19.
Progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the brain, is typically diagnosed in immunocompromised persons. Here, we describe diagnostic challenge PML an apparently immunocompetent patient. Thorough analyses, including cytokine release assays and whole exome sequencing, revealed deficit antiviral interferon gamma production capacity this patient compound heterozygous mutations BCL-2-associated athanogene 3. Interestingly, both factors are associated with...
We prospectively investigated the role of depressive symptoms (DS) on all-cause dementia in a population with small vessel disease (SVD), considering onset age DS and cognitive performance.The RUN DMC study (Radboud University Nijmegen Diffusion Tensor Magnetic Resonance Cohort) is prospective cohort among 503 older adults SVD MRI without at baseline (2006), follow-up 5 years (2012). Kaplan-Meier curves stratified for risk were compared using log-rank test. calculated hazard ratios Cox...
Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between volume and LODS, independent of 503 participants symptomatic SVD. Methods. Patients underwent FLAIR T1 scanning. Depressive were assessed structured questionnaires; WML manually segmented. The LODS/EODS was adjusted for age, sex, intracranial volume,...
We present a case of patient with multiple sclerosis who was treated plasmapheresis and valproic acid. used therapeutic drug monitoring to determine whether plasma concentrations acid were kept within the window amount that removed by plasmapheresis.
Cerebral small vessel disease (SVD) is cross-sectionally associated with gait disturbances, however, the relation between baseline SVD and decline over time uncertain. Furthermore, diffusion tensor imaging (DTI) studies on are currently lacking.To investigate association markers decline.In 2006, 310 participants from RUN DMC cohort, a prospective cohort older adults aged 50-85 years SVD, were included. Gait variables assessed using computerized walkway during follow-up. Linear logistic...