A5040239277- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Prostate Cancer Treatment and Research
- Cerebrovascular and Carotid Artery Diseases
- Multiple and Secondary Primary Cancers
- Neural and Behavioral Psychology Studies
- Prostate Cancer Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Transcranial Magnetic Stimulation Studies
- Cerebrovascular and genetic disorders
- Ear and Head Tumors
- Cardiac Arrhythmias and Treatments
- Cancer and Skin Lesions
- Blood Pressure and Hypertension Studies
- Genetic factors in colorectal cancer
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Cancer, Lipids, and Metabolism
University of Cambridge
2018-2023
The Scarborough Hospital
2019
University of Toronto
2019
St George's, University of London
2019
Radboud University Medical Center
2019
University of Oxford
2019
Radboud University Nijmegen
2019
Fogarty Institute for Innovation
2017
Memorial Regional Hospital
2017
University of Saint Mary
2014
<h3>Objective</h3> To investigate whether white matter network disruption underlies the pathogenesis of apathy, but not depression, in cerebral small vessel disease (SVD). <h3>Methods</h3> Three hundred thirty-one patients with SVD from Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) study completed measures apathy depression underwent structural MRI. Streamlines reflecting underlying fibers were reconstructed diffusion tensor tractography. First, path...
There has been much interest in how the hippocampus codes time support of episodic memory. Notably, while rodent hippocampal neurons, including populations subfield CA1, have shown to represent passage order seconds between events, there is limited for a similar mechanism humans. Specifically, no clear evidence that human activity during long-term memory processing sensitive temporal duration information spans seconds. To address this gap, we asked participants first learn short event...
Objectives To investigate whether longitudinal structural network efficiency is associated with cognitive decline and baseline predicts mortality in cerebral small vessel disease (SVD). Methods A prospective, single-centre cohort consisting of 277 non-demented individuals SVD was conducted. In 2011 2015, all participants were scanned MRI underwent neuropsychological assessment. We computed properties using graph theory from probabilistic tractography calculated changes psychomotor speed...
Background and Purpose- Cerebrovascular disease contributes to age-related cognitive decline, but the mechanisms underlying this phenomenon remain incompletely understood. We hypothesized that vascular risk factors would lead impairment through disruption of brain white matter network efficiency. Methods- Participants were 19 346 neurologically healthy individuals from UK Biobank underwent diffusion MRI testing (mean age=62.6). Global efficiency, a measure integration, was calculated...
Abstract Background Obesity is a risk factor for both cardiovascular disease and dementia, but the mechanisms underlying this association are not fully understood. We examined associations between obesity, including estimates of central obesity using different modalities, with brain gray matter (GM) volume in UK Biobank, large population-based cohort study. Methods To determine relationships we used MRI, abdominal dual-energy X-ray absorptiometry (DXA), bioelectric whole-body impedance....
White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals SVD. We hypothesize that WMH might exert their effect on indirectly by affecting remote brain structures such as hippocampus. investigated temporal interactions between WMH, hippocampal atrophy older adults Five hundred three participants RUNDMC study...
Background and Purpose- Cerebral autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL) is the most common monogenic form of stroke usually presenting migraine aura, lacunar infarcts, cognitive impairment. Acute encephalopathy a less recognized presentation disease. Methods- Data collected prospectively from 340 consecutively recruited symptomatic patients diagnosis CADASIL seen in British National clinic was retrospectively reviewed original clinical records...
Objective To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging Stroke (SCANS; n=121) Radboud University Nijmegen Diffusion Tensor Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were to predict using baseline scores both datasets. Change was a subset 104 participants with longitudinal data from SCANS. All models...
Cerebral small vessel disease is a leading cause of cognitive decline and vascular dementia. Small pathology changes structural brain networks, but its impact on functional networks remains poorly understood. Structural are closely coupled in healthy individuals, decoupling associated with clinical symptoms other neurological conditions. We tested the hypothesis that structural-functional network coupling related to neurocognitive outcomes 262 patients.Participants underwent multimodal...
Objective: Apathy is a common and disabling symptom after stroke with no proven treatments. Selective serotonin reuptake inhibitors are widely used to treat depressive symptoms post-stroke but whether they reduce apathetic unknown. We determined the effect of fluoxetine on apathy in post hoc analysis EFFECTS (Efficacy oF Fluoxetine—a randomized Controlled Trial Stroke) trial. Methods: enrolled patients ⩾18 years between 2 15 days onset. Participants were randomly assigned receive oral 20 mg...
Background Hypertension is strongly associated with cardiovascular diseases such as heart failure, stroke, kidney disease, and has been correlated an increased risk for attack. Current treatment regimens hypertension are highly inadequate, reports indicating that only 50.1% of the clinical population disease their blood pressure under control. Objective To study feasibility using minimally invasive radiosurgery to ablate renal nerves a novel refractory hypertension, assess safety efficacy...
Abstract Background Cerebral small vessel disease (SVD) leads to reduced quality of life (QOL), but the mechanisms underlying this relationship remain unknown. This study investigated multivariate relationships between radiological markers SVD and domain‐specific QOL deficits, as well potential mediators, in patients with SVD. Methods Clinical neuroimaging measures were obtained from a pooled sample 174 St. George's Cognition Neuroimaging Stroke PRESsure established cERebral VEssel studies....
The medial temporal lobe (MTL) has been implicated in approach-avoidance (AA) conflict processing, which arises when a stimulus is imbued with both positive and negative valences. Notably, since the MTL traditionally viewed as mnemonic brain region, pertinent question how AA memory processing interact each other behaviourally. We conducted two behavioural experiments to examine whether increased significant impact on incidental encoding inferential reasoning. In Experiment 1, participants...
Background: Cerebral small vessel disease is a leading cause of cognitive decline and vascular dementia. Small pathology changes structural brain networks, but its impact on functional networks remains poorly understood. Structural are closely coupled in healthy individuals, decoupling associated with clinical symptoms other neurological conditions. We tested the hypothesis that structural-functional network coupling related to neurocognitive outcomes 262 patients.Methods: Participants...