A5012727262- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Memory Processes and Influences
- Child and Animal Learning Development
- Neural and Behavioral Psychology Studies
- Speech and dialogue systems
- Stress Responses and Cortisol
- Neurobiology of Language and Bilingualism
University of Toronto
2015-2022
The Scarborough Hospital
2016-2022
Rodent models of anxiety have implicated the ventral hippocampus in approach–avoidance conflict processing. Few studies have, however, examined whether human plays a similar role. We developed novel decision-making paradigm to examine neural activity when participants made approach/avoidance decisions under conditions high or absent conflict. Critically, our task required learn associated reward/punishment values previously neutral stimuli and controlled for mnemonic spatial processing...
There has been much interest in how the hippocampus codes time support of episodic memory. Notably, while rodent hippocampal neurons, including populations subfield CA1, have shown to represent passage order seconds between events, there is limited for a similar mechanism humans. Specifically, no clear evidence that human activity during long-term memory processing sensitive temporal duration information spans seconds. To address this gap, we asked participants first learn short event...
In order to function optimally within our environment, we continuously extract temporal patterns from experiences and formulate expectations that facilitate adaptive behavior. Given memories are embedded spatiotemporal contexts, an intriguing possibility is mnemonic processes sensitive the structure of events. To test this hypothesis, in a series behavioral experiments manipulated regularity interval durations at encoding create temporally structured unstructured frameworks. Our findings...
Surprisingly little is known about how the brain combines spatial elements to form a coherent percept. Regions that may underlie this process include hippocampus (HC) and parahippocampal place area (PPA), regions central perception but whose role in coherency has not been explored. Participants were scanned with functional MRI while they judged whether Escher-like scenes possible or impossible. Univariate analyses revealed differential HC PPA involvement, greater activity during incoherency...
Recent interest in the role of hippocampus temporal aspects cognition has been fueled, part, by observation "time" cells rodent hippocampus-that is, that have differential firing patterns depending on how long ago an event occurred. Such are thought to provide internal representation elapsed time. Yet, is not needed for processing duration information per se, at least order seconds, as evidenced intact judgments rodents and humans with hippocampal damage. Rather, it proposed may be essential...
Abstract The rodent ventral and primate anterior hippocampus have been implicated in approach–avoidance (AA) conflict processing. It is unclear, however, whether this structure contributes to AA detection and/or resolution, if its involvement extends conditions of devoid spatial/contextual information. To investigate this, neurologically healthy human participants first learned approach or avoid single novel visual objects with the goal maximizing earned points. Approaching led point gain...
The medial temporal lobe (MTL) has been implicated in approach-avoidance (AA) conflict processing, which arises when a stimulus is imbued with both positive and negative valences. Notably, since the MTL traditionally viewed as mnemonic brain region, pertinent question how AA memory processing interact each other behaviourally. We conducted two behavioural experiments to examine whether increased significant impact on incidental encoding inferential reasoning. In Experiment 1, participants...
Temporal information, including information about temporal order and duration, is a fundamental component of event sequence memory. While previous research has demonstrated that aging can have detrimental effect on memory for order, there been limited insight into the durations, particularly within context sequences. In current study, neurologically healthy young older participants were administered two match-mismatch tasks: one in which they instructed each trial to compare or duration...