A5034139877- Vestibular and auditory disorders
- Spaceflight effects on biology
- Ophthalmology and Eye Disorders
- Functional Brain Connectivity Studies
- High Altitude and Hypoxia
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Neuroimaging Techniques and Applications
- Ocular Surface and Contact Lens
- Cerebrospinal fluid and hydrocephalus
- Multisensory perception and integration
- Paranormal Experiences and Beliefs
- Visual perception and processing mechanisms
University of Antwerp
2022-2025
Birkbeck, University of London
2025
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these whether they equally affect crews different space agencies remain unknown. We used MRI analyze alterations occurring in perivascular spaces (PVS) NASA European Space Agency astronauts Roscosmos cosmonauts after a 6-mo on International Station (ISS). found increased volume basal ganglia...
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue become a space-faring species, it is imperative that fully understand the occur in human body, including brain. In this study, present findings brain structural associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average six months aboard International Space Station (ISS) were scanned MRI scanner...
The prospect of continued manned space missions warrants an in-depth understanding how prolonged microgravity affects the human brain. Functional magnetic resonance imaging (fMRI) can pinpoint changes reflecting adaptive neuroplasticity across time. We acquired resting-state fMRI data cosmonauts before, shortly after, and eight months after spaceflight as a follow-up to assess global connectivity over Our results show persisting decreases in posterior cingulate cortex thalamus increases...
Introduction Mal de Debarquement Syndrome (MdDS) is a debilitating neuro-otological disorder. Patients experience almost continuously perception of self-motion. This syndrome can be motion-triggered (MT-MdDS), such as on boat, or occur spontaneously have other triggers (SO-MdDS) in the absence motion. Because pathophysiological mechanism unknown, treatment options and symptom management strategies are limited. One available protocol involves readaptation vestibular ocular reflex (VOR). study...
Mal de Debarquement Syndrome (MdDS) is a debilitating neuro-otological disorder where individuals consistently feel self-motion, often triggered by motion like being on boat (MT-MdDS). Due to the unknown pathophysiological mechanism, available treatment options for managing symptoms are limited. Our objective was develop virtual reality application (VRA) simulate full field optokinetic stimulation (OKS) booth and evaluate its efficacy compared standard treatment. In our randomized, open,...
Otoliths are the primary gravity sensors of vestibular system and responsible for ocular counter-roll (OCR). This compensatory eye torsion ensures gaze stabilization is sensitive to a head roll with respect Gravito-Inertial Acceleration vector during, e.g., centrifugation. To measure effect prolonged spaceflight on otoliths, we quantified OCR induced by off-axis centrifugation in group 27 cosmonauts an upright position before after their 6-month space mission International Space Station. We...
The vestibular (otolith) function is highly suppressed during space flight (SF) and the study of these changes very important for safety crew SF missions. (particularly, otolith-ocular reflex-OOcR) in clinical medicine studied using different methodologies. However, methods methodologies can influence outcome results.The current addresses question whether OOcR results obtained by are different, what role afferent systems modulation OOcR.A total 25 Russian cosmonauts voluntarily took part our...
The otoliths of the vestibular system are seen as primary gravitational sensors and responsible for a compensatory eye torsion called ocular counter-roll (OCR). OCR ensures gaze stabilization is sensitive to lateral head roll with respect gravity Gravito-Inertial Acceleration (GIA) vector during e.g., centrifugation. This otolith-mediated reflex will make sure you still be able maintain postural stability when making sharp turns locomotion. To measure effect prolonged spaceflight on...