A5026690939- Spaceflight effects on biology
- Thermoregulation and physiological responses
- Sodium Intake and Health
- Body Composition Measurement Techniques
- High Altitude and Hypoxia
- Anesthesia and Neurotoxicity Research
- Medical and Biological Ozone Research
- Space Exploration and Technology
- Vitamin D Research Studies
- Climate Change and Health Impacts
- Muscle metabolism and nutrition
- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Stress Responses and Cortisol
- Biochemical effects in animals
- Bone health and osteoporosis research
- Nutritional Studies and Diet
- Physical Activity and Health
- Muscle Physiology and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Human Health and Disease
- Advanced MRI Techniques and Applications
- Technology and Human Factors in Education and Health
- Dental Implant Techniques and Outcomes
Institute of Biomedical Problems
2015-2025
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2015
Max Delbrück Center
2015
Charité - Universitätsmedizin Berlin
2015
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015
Fresenius Medical Care (Germany)
2015
Vanderbilt University
2014-2015
Accurately collected 24-hour urine collections are presumed to be valid for estimating salt intake in individuals. We performed 2 independent ultralong-term balance studies lasting 105 (4 men) and 205 (6 days 10 men simulating a flight Mars. controlled dietary of all constituents months at intakes 12, 9, 6 g/d urine. The subjects’ daily menus consisted 27 279 individual servings, which 83.0% were completely consumed, 16.5% rejected, 0.5% incompletely consumed. Urinary recovery was 92%...
Risk for premature osteoporosis is a major health concern in astronauts and cosmonauts; the reversibility of bone lost at weight-bearing sites not established, although it suspected to take longer than mission length. The three-dimensional structure strength that could be uniquely affected by weightlessness currently unknown. Our objective evaluate mass, microarchitecture, non-weight-bearing 13 cosmonauts before 12 months after 4-month 6-month sojourn International Space Station (ISS)....
Space flight exerts a specific conglomerate of stressors on humans that can modulate the immune system. The mechanism remains to be elucidated and consequences for cosmonauts in long term are unclear. Most current research stems from short-term spaceflights as well pre- post-flight analyses due operational limitations. Immune function 12 participating long-duration (>140days) spaceflight mission was monitored pre-, post-, two time-points in-flight. While classical markers stress such...
Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronauts' health safety. However, consequences on B-cell development responses still under-investigated. To fill this gap, we used advanced proteomics analysis femur bone marrow to compare mice flown for 1 mo board BION-M1 biosatellite, followed or not by wk recovery Earth, control kept Earth. Our data revealed an effect B lymphopoiesis after landing. This phenomenon was associated with a 41%...
Abstract Environmental factors have long been known to influence immune responses. In particular, clinical studies about the association between migration and increased risk of atopy/asthma provided important information on role associated large sets environmental exposures in development allergic diseases. However, investigations effects responses are mostly limited candidate exposures, such as air pollution. The influences still largely unknown. A simulated 520-d Mars mission an...
This article describes procedures and some results of the first study females undergoing 3-day Dry Immersion. The experiment “NAIAD-2020” was carried out at Institute Biomedical Problems (Moscow, Russia) with participation six healthy women volunteers (age 30.17 ± 5.5 years, height 1.66 0.1 m, weight 62.05 8.4 kg, BMI 22.39 2.2 kg/m 2 ) a natural menstrual cycle. During study, standard protocol used, same as for men, minimum period time spent outside immersion bath. Before, during after...
The innate immune system as one key element of immunity and a prerequisite for an adequate host defense is emerging interest in space research to ensure crew health thus mission success. In ground-based studies, spaceflight-associated specifics such confinement caused altered functions paralleled by changes stress hormone levels. this study, six men were confined 105 days module ~500 m(3) mimicking conditions long-term mission. Psychic was surveyed different questionnaires. Blood, saliva,...
The Mars-105 project was aimed at simulating crew's activities, workload, and communication during a mission to Mars, evaluating the homeostatic adaptations prolonged confinement cohabitation.Fasting plasma glucose (FPG) insulin, C-peptide, leptin, cortisol, NGF BDNF levels were monitored in six healthy nonsmoking male subjects taking part 105-d Mars simulation. Samples collected from each subject before (0 wk), (2.5 wk; 5 10 15 after (+1 wk).Confinement resulted impaired glucometabolic...
Abstract Exercise could prevent physical and psychological deteriorations, especially during pandemic times of lock-down scenarios social isolation. But to meet both, the common exercise protocols require optimization based on holistic investigations with respect underlying processes. This study aimed explore individual chronic acute effects continuous interval running cognitive performance, mood, affect neurophysiological factors a terrestrial simulated space mission. Six volunteers (three...
Objective: The creation of artificial gravity on board a space station is one the promising methods for preventing health problems during missions; short-radius centrifuge (SRC) model such method Earth. Our goal was to evaluate sensitivity bioimpedance polysegmental measurements monitoring body regions' blood-filling redistribution and analyze dynamics rotation in three SRC modes. Approach: Nine healthy male volunteers have been observed under modes with maximum acceleration 2.05 standard...
The influence of gravitational unloading (antiorthostatic suspension) and subsequent recovery on the mineral density mechanical properties femoral tibial bones Wistar rats was studied with oral administration a biotechnological analog human lactoferrin (200 mg/kg) derived from milk producer goats. Bone determined by dual-energy X-ray absorptiometry, strength stiffness were assessed through three-point bending tests. It shown that for 21 days led to decrease in bones. did not significantly...
Introduction: A decrease in sleep quality and duration during space missions has repeatedly been reported. However, the exact causes that underlie this effect remain unclear. In space, might be impacted by weightlessness its influence on cardiovascular function. study, we aimed at exploring changes of night architecture prolonged, 21-day Dry Immersion (DI) as one ground-based models for microgravity studies comparing them with adaptive system. Methods: Ten healthy young men were exposed to...