A5039577349- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Acute Ischemic Stroke Management
- Psychedelics and Drug Studies
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Hemodynamic Monitoring and Therapy
- Neurotransmitter Receptor Influence on Behavior
- Family and Patient Care in Intensive Care Units
- Tryptophan and brain disorders
- Optical Imaging and Spectroscopy Techniques
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Long-Term Effects of COVID-19
- Pediatric Pain Management Techniques
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- High Altitude and Hypoxia
Michigan Medicine
2015-2025
University of Michigan
2015-2024
Multidisciplinary Association for Psychedelic Studies
2022-2023
Committee on Publication Ethics
2016-2021
University of Pennsylvania
2019
Northwestern University
2017
Novem (Netherlands)
2017
University of Wisconsin–Madison
2016
Methodist Hospital
2016
University of Auckland
2016
Abstract Background Previous studies have demonstrated inconsistent neurophysiologic effects of ketamine, although discrepant findings might relate to differences in doses studied, brain regions analyzed, coadministration other anesthetic medications, and resolution the electroencephalograph. The objective this study was characterize dose-dependent ketamine on cortical oscillations functional connectivity. Methods Ten healthy human volunteers were recruited for participation. data recorded...
The isolated forearm technique allows assessment of consciousness the external world (connected consciousness) through a verbal command to move hand (of tourniquet-isolated arm) during intended general anesthesia. Previous data suggest that incidence connected may approach 37% after noxious stimulus. authors conducted an international, multicenter, pragmatic study establish responsiveness intubation in routine practice.Two hundred sixty adult patients were recruited at six sites into...
Recent modeling and empirical studies support the hypothesis that large-scale brain networks function near a critical state. Similar functional connectivity patterns derived from resting state data network models at criticality provide further support. However, despite strong implication of relationship, there has been no principled explanation how shapes characteristic in networks. Here, we hypothesized science concept partial phase locking is underlying mechanism optimal We provides...
Conscious access to sensory information is likely gated at an intermediate site between primary and transmodal association cortices, but the structure responsible remains unknown. We perform functional neuroimaging determine neural correlates of conscious using a volitional mental imagery task, report paradigm not confounded by motor behavior. Titrating propofol loss behavioral responsiveness in healthy volunteers creates dysfunction anterior insular cortex (AIC) with impairment dynamic...
<ns4:p>Postoperative delirium is a common and harrowing complication in older surgical patients. Those with cognitive impairment or dementia are at especially high risk for developing postoperative delirium; ominously, it hypothesized that can accelerate decline the onset of dementia, worsen severity dementia. Awareness has grown recent years as various medical societies have launched initiatives to prevent alleviate its impact. Unfortunately, pathophysiology not well understood this likely...
The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at 5-HT
Numerous risk factors have been identified for perioperative stroke, but there are conflicting data regarding the role of β adrenergic receptor blockade in general and metoprolol particular.The authors retrospectively screened 57,218 consecutive patients radiologic evidence stroke within 30 days after noncardiac procedures at a tertiary care university hospital. Incidence surgery associated were assessed. Patients taking either or atenolol matched based on number stroke. Parsimonious...
Anesthetic-induced loss of consciousness is accompanied by changes in functional connectivity within and between brain networks.Despite a stable surgical level anesthesia the absence noxious stimuli, patterns are not static but rather fluctuate dynamically nonrandomly over time. These results suggest that single or may be able to discriminate levels consciousness.Recent studies anesthetic-induced unconsciousness healthy volunteers have focused on patterns, protocols rarely parallel depth...
Functional connectivity across the cortex has been posited to be important for consciousness and anesthesia, but functional patterns during course of surgery general anesthesia are unknown. The authors tested hypothesis that disrupted cortical would correlate with surgical anesthesia.Surgical patients (n = 53) were recruited study participation. Whole-scalp (16-channel) wireless electroencephalographic data prospectively collected throughout perioperative period. was assessed using weighted...
Ketamine is a general anaesthetic with anti-depressant effects at subanaesthetic doses. We hypothesised that intraoperative administration of ketamine would prevent or mitigate postoperative depressive symptoms in surgical patients.We conducted an international, randomised clinical trial testing the [0.5 mg kg-1 (Lo-K) 1.0 (Hi-K)] vs control [saline placebo (P)] patients ≥60 yr old undergoing major surgery anaesthesia. administered Patient Health Questionnaire-8 before operation, on day...
Cognitive training is beneficial in various clinical settings, although its perioperative feasibility and impact remain unknown. The objective of this pilot study was to determine the home-based cognitive prehabilitation before major surgery older adults.Sixty-one patients were enrolled, randomized, allocated either a preoperative regimen or no surgery. Outcomes included postoperative delirium incidence (primary outcome; assessed with 3D-Confusion Assessment Method), function based on NIH...
Perioperative stroke is associated with considerable morbidity and mortality. Stroke recognition diagnosis are challenging perioperatively, surgical patients receive therapeutic interventions less frequently compared in the outpatient setting. These updated guidelines from Society for Neuroscience Anesthesiology Critical Care provide evidence-based recommendations regarding perioperative care of at high risk stroke. Recommended areas future investigation also proposed.
Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it particularly common among older adults, closely linked with underlying neurocognitive disorders. Evidence mounting that intervening on delirium may represent important opportunity for delaying onset or progression dementia. To accelerate current understanding delirium, Network Investigation Delirium: Unifying Scientists (NIDUS) held a conference "Advancing Research: A Scientific Think Tank" in...
Objective To characterise the clinical course of delirium for patients with COVID-19 in intensive care unit, including postdischarge neuropsychological outcomes. Design Retrospective chart review and prospective survey study. Setting Intensive units, large academic tertiary-care centre (USA). Participants Patients (n=148) admitted to an unit at Michigan Medicine between 1 March 2020 31 May were eligible inclusion. Primary secondary outcome measures Delirium was primary outcome, assessed via...
Anesthetics are known to disrupt neural interactions in cortical and subcortical brain circuits. While the effect of anesthetic drugs on consciousness is reversible, mechanism mediating induction recovery may be different. Insight into these distinct mechanisms can gained from a systematic comparison dynamics during slow emergence anesthesia. To this end, we used functional magnetic resonance imaging (fMRI) data obtained healthy volunteers before, during, after administration propofol at...
Background Perioperative neurocognitive disorders are a major public health issue, although there no validated neurophysiologic biomarkers that predict cognitive function after surgery. This study tested the hypothesis preoperative posterior electroencephalographic alpha power, frontal-parietal connectivity, and cerebral oximetry would each correlate with postoperative function. Methods was single-center, prospective, observational of adult (older than 18 yr) male female noncardiac surgery...
Delirium in hospitalized patients is a major public health issue, yet delirium often unrecognized and missed during inpatient admission. The objective of this study was to identify barriers screening, identification, management from nursing perspective on inpatient, acute care units.This pre-implementation, diagnostic evaluation determine current practice patterns potential optimizing at university hospital. A qualitative approach used, which included focus groups nurses working medical...
Detecting covert consciousness in behaviorally unresponsive patients by brain imaging is of great interest, but a reproducible model and evidence from independent sources still lacking. Here we demonstrate the possibility using general anesthetics within-subjects study design to test methods or statistical paradigms assessing consciousness. Using noninvasive neuroimaging healthy volunteers, identified participant who was able exhibit specific fMRI signatures volitional mental imagery while...