Aleda M. Leis

ORCID: 0000-0003-2867-9062
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About
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Research Areas
  • Cardiac, Anesthesia and Surgical Outcomes
  • Anesthesia and Sedative Agents
  • Airway Management and Intubation Techniques
  • Intensive Care Unit Cognitive Disorders
  • Respiratory viral infections research
  • Influenza Virus Research Studies
  • Anesthesia and Pain Management
  • Pediatric Pain Management Techniques
  • Respiratory Support and Mechanisms
  • Obstructive Sleep Apnea Research
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Tracheal and airway disorders
  • COVID-19 Clinical Research Studies
  • Cardiac and Coronary Surgery Techniques
  • Hemodynamic Monitoring and Therapy
  • Hip and Femur Fractures
  • Pneumonia and Respiratory Infections
  • Autism Spectrum Disorder Research
  • Nausea and vomiting management
  • Long-Term Effects of COVID-19
  • Anesthesia and Neurotoxicity Research
  • Obesity, Physical Activity, Diet
  • Child Nutrition and Feeding Issues
  • COVID-19 and Mental Health
  • Cerebral Palsy and Movement Disorders

University of Michigan
2016-2024

Michigan United
2017-2024

Michigan Medicine
2016-2023

Weatherford College
2023

C. S. Mott Children's Hospital
2019-2021

University of Virginia Health System
2021

Committee on Publication Ethics
2021

Creative Commons
2019

American Society of Anesthesiologists
2019

University of Pennsylvania
2015-2019

On June 21, 2023, CDC's Advisory Committee on Immunization Practices recommended respiratory syncytial virus (RSV) vaccination for adults aged ≥60 years, offered to individual using shared clinical decision-making.Informed use of these vaccines requires an understanding RSV disease severity.To characterize RSV-associated severity, 5,784 years hospitalized with acute illness and laboratory-confirmed RSV, SARS-CoV-2, or influenza infection were prospectively enrolled from 25 hospitals in 20...

10.15585/mmwr.mm7240a2 article EN MMWR Morbidity and Mortality Weekly Report 2023-10-05

Importance On June 21, 2023, the Centers for Disease Control and Prevention recommended first respiratory syncytial virus (RSV) vaccines adults aged 60 years older using shared clinical decision-making. Understanding severity of RSV disease in can help guide this Objective To describe among hospitalized with compare it COVID-19 influenza by vaccination status. Design, Setting, Participants In cohort study, 18 admitted to hospital acute illness laboratory-confirmed RSV, SARS-CoV-2, or...

10.1001/jamanetworkopen.2024.4954 article EN cc-by-nc-nd JAMA Network Open 2024-04-04

Background Protective ventilation may improve outcomes after major surgery. However, in the context of one-lung ventilation, such a strategy is incompletely defined. The authors hypothesized that putative protective regimen would be independently associated with decreased odds pulmonary complications thoracic Methods merged Society Thoracic Surgeons Database and Multicenter Perioperative Outcomes Group intraoperative data for lung resection procedures using across five institutions from 2012...

10.1097/aln.0000000000003729 article EN Anesthesiology 2021-02-26

Assessing variant-specific COVID-19 vaccine effectiveness (VE) and severity can inform public health risk assessments decisions about composition. BA.2.86 its descendants, including JN.1 (referred to collectively as "JN lineages"), emerged in late 2023 exhibited substantial divergence from co-circulating XBB lineages.

10.1093/cid/ciae405 article EN public-domain Clinical Infectious Diseases 2024-08-06

The relationship between sleep duration and obesity in adolescents is inconclusive. This may stem from a more complex than previously considered. Shifts toward evening preferences, later sleep-wake times irregular patterns are typical during adolescence but their to body mass index (BMI) has been relatively unexplored. cross-sectional study examined associations duration, midpoint of social jet lag (estimated 7 days continuous actigraphy monitoring), morningness/eveningness with BMIs (BMI...

10.1080/07420528.2016.1196697 article EN Chronobiology International 2016-08-11

Background Perioperative neurocognitive disorders are a major public health issue, although there no validated neurophysiologic biomarkers that predict cognitive function after surgery. This study tested the hypothesis preoperative posterior electroencephalographic alpha power, frontal-parietal connectivity, and cerebral oximetry would each correlate with postoperative function. Methods was single-center, prospective, observational of adult (older than 18 yr) male female noncardiac surgery...

10.1097/aln.0000000000004664 article EN Anesthesiology 2023-06-26

Sleep is a complex behavior with numerous health implications. Identifying sociodemographic and behavioral characteristics of sleep important for determining those at greatest risk sleep-related disparities. In this cross-sectional study, general linear models were used to examine associated duration, chronotype, social jet lag in adolescents. One hundred fifteen participants completed Phase I (self-reported measures), 69 these II (actigraphy-estimated measures). Black adolescents had...

10.1177/1059840515603454 article EN The Journal of School Nursing 2015-09-16

: High-density lipoprotein cholesterol (HDL-C) is one of 5 components [high blood pressure, glucose, triglycerides, waist circumference, low HDL-C], 3 which, needed to diagnose metabolic syndrome (MetS). Evolving research shows that higher HDL-C not necessarily cardioprotective in midlife women, supporting a need re-evaluate HDL-C's contribution risks related MetS. We tested whether risk future diabetes and carotid intima-media thickness (cIMT) differ by status women diagnosed with MetS...

10.1016/j.ajpc.2024.100687 article EN cc-by-nc American Journal of Preventive Cardiology 2024-06-20

Abstract Background Data on the true prevalence of respiratory syncytial virus (RSV) among medically attended acute illnesses (MAARI) has been limited by lack regular clinical testing mild to moderate illnesses. Here we present a prospective evaluation epidemiology RSV-associated MAARI across age groups and multimorbidity status over 3 seasons, which is informative in light recommendations for shared decision making vaccination older adults. Methods Ambulatory patients ≥6 months meeting...

10.1093/cid/ciae303 article EN Clinical Infectious Diseases 2024-06-04

Objectives/Goals: Physical activity (PA) is a well-documented protective factor against many cardiovascular diseases. PA guidelines to reduce these risks and the impact of variability are unclear, most studies only examine 7-day window. This study aimed factors related in step counts 3-year adults aged ≥18 years. Methods/Study Population: Included were 6,525 participants from Michigan Predictive Ability Clinical Trajectories study, prospective cohort community-dwelling enrolled between...

10.1017/cts.2024.763 article EN cc-by-nc-nd Journal of Clinical and Translational Science 2025-03-26

BACKGROUND: The critical question of racial and gender diversity in pediatric anesthesia training programs has not been previously explored. primary objective this study was to evaluate trends by race/ethnicity anesthesiology fellowship the United States for years 2000 2018. METHODS: Demographic data on fellows residents were obtained from self-reported collected Journal American Medical Association ’s annual report Graduate Education Diversity assessed calculating proportions trainees per...

10.1213/ane.0000000000004765 article EN Anesthesia & Analgesia 2020-03-27

Unconscious racial bias in anesthesia care has been shown to exist. We hypothesized that black children may undergo inhalation induction less often, receive support from child life, have fewer opportunities a family member present for induction, and premedication with oral midazolam often.We retrospectively collected data on those <18 years of age January 1, 2012 2018 including age, sex, race, height, weight, American Society Anesthesiologists (ASA) physical status, surgical service,...

10.1213/ane.0000000000004274 article EN Anesthesia & Analgesia 2019-07-11

The relationship between intraoperative physiology and postoperative stroke is incompletely understood. Preliminary data suggest that either hypo- or hypercapnia coupled with reduced cerebrovascular inflow (e.g., due to hypotension) can lead ischemia. This study tested the hypothesis combination of hypotension hypercarbia associated ischemic stroke.We conducted a retrospective, case-control via Multicenter Perioperative Outcomes Group. Noncardiac, nonintracranial, nonmajor vascular surgical...

10.1097/aln.0000000000004354 article EN Anesthesiology 2022-08-12

Introduction The clinical importance of postoperative episodic hypoxemia is still unclear, and therefore largely under-studied. As a result, there limited understanding its relationship with early respiratory complications (PRC, defined as intubation within three days surgery) hospital resource utilization. Materials methods This single center study was performed using retrospective observational design. We described population based definitions desaturation from continuous SpO2 monitoring...

10.1371/journal.pone.0175408 article EN cc-by PLoS ONE 2017-05-17

Caring for children with autism spectrum disorder (ASD) can be highly demanding and put significant strain on caregivers. To date, little is known about the extent to which caregivers of ASD experience increased levels stress may adversely affect health outcomes. The purpose this secondary analysis was compare typically developing (TDC) in weight status, diet quality, perceived related parenting role, functional well-being.Caregivers 25 30 TDC completed 2005 Block Food Frequency...

10.1111/jspn.12205 article EN Journal for Specialists in Pediatric Nursing 2017-12-14

Despite growing evidence supporting the potential benefits of higher end-tidal carbon dioxide (ETCO2) levels in surgical patients, there is still insufficient data to formulate guidelines for ideal intraoperative ETCO2 targets. As it unclear which are currently used and whether these have changed over time, we investigated practice pattern using Multicenter Perioperative Outcomes Group database.This retrospective, observational, multicentre study included 317,445 adult patients who received...

10.1007/s12630-018-1249-1 article FR cc-by-nc Canadian Journal of Anesthesia/Journal canadien d anesthésie 2018-11-14

Abstract Background While pre and postoperative hyperglycemia is associated with increased risk of surgical site infection, myocardial infarction, stroke death, there are no multicenter data regarding the association intraoperative blood glucose levels outcomes for non-cardiac population. Methods We conducted a retrospective cohort study from Michigan Surgical Quality Collaborative, network 64 hospitals that prospectively collects validated on patients purpose quality improvement. included...

10.1186/s12871-020-01022-w article EN cc-by BMC Anesthesiology 2020-05-07
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