A5078406235- Menopause: Health Impacts and Treatments
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Estrogen and related hormone effects
- Cardiovascular Health and Risk Factors
- Phytoestrogen effects and research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal and reproductive studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and preeclampsia studies
- Nutrition and Health in Aging
- Ovarian function and disorders
- Birth, Development, and Health
- Sex and Gender in Healthcare
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Physical Activity and Health
- Menstrual Health and Disorders
- Uterine Myomas and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Health disparities and outcomes
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
University of Pittsburgh
2016-2025
Bastyr University
2021-2023
Weatherford College
2022
Rush University Medical Center
2021
University of Samarra
2012-2020
National Institute on Aging
2020
National Institutes of Health
2020
October 6 University
2020
National Institute of Nursing Research
2020
Anna Needs Neuroblastoma Answers
2020
"The 2022 Hormone Therapy Position Statement of The North American Menopause Society" (NAMS) updates 2017 and identifies future research needs. An Advisory Panel clinicians researchers expert in the field women's health menopause was recruited by NAMS to review Statement, evaluate new literature, assess evidence, reach consensus on recommendations, using level evidence identify strength recommendations quality evidence. Panel's were reviewed approved Board Trustees.Hormone therapy remains...
Up to 50% of women report sleep problems in midlife, and cardiovascular disease (CVD) is the leading cause death women. How chronic poor exposure over decades midlife related CVD risk poorly understood. We tested whether trajectories insomnia symptoms or duration were subsequent events among SWAN (Study Women's Health Across Nation) participants, whose was assessed up 16 times 22 years.
To analyze the impact of body mass indices on postbariatric reconstructive surgery complications.An increasing number patients are presenting after massive weight loss due to bariatric or diet and exercise. Many these have residual obesity, which may compromise outcomes.449 were enrolled in a prospective registry over 6 years. Measures included medical complications comorbidities. All cases analyzed together as well two subgroups: single procedure (Group I) multiple II).449 (407 female, 42...
Variability in the pattern of change estradiol (E2) and FSH levels over menopause transition has not been well defined.The current study aimed to determine whether different trajectories E2 could be identified race/ethnicity body mass index were related trajectories.The Study Women's Health Across Nation is a longitudinal observational menopausal transition.Women aged 42-52 yr from seven participating sites recruited underwent up 11 annual visits.Postmenopausal women with 12 or more months...
The aim of this study is to assess whether the levels and progression rates carotid intima-media thickness (IMT) adventitial diameter (AD) vary by menopausal stage.Two hundred forty-nine women (aged 42-57 y; 49% premenopausal 46% early perimenopausal) from Study Women's Health Across Nation were included in current analysis. Participants followed up for 9 years (median, 3.7 y) underwent five scans. Linear mixed-effect models used analysis.The overall rate change IMT was 0.007 mm/year....
Emerging research suggests links between menopausal hot flashes and cardiovascular disease risk. The mechanisms underlying these associations are unclear, due to the incomplete understanding of physiology flashes. OBJECTIVE AND MAIN OUTCOME MEASURES: We examined flashes/night sweats glucose insulin resistance over 8 yr, controlling for risk factors reproductive hormones.Participants in Study Women's Health Across Nation (SWAN) (n=3075), a longitudinal cohort study, were ages 42-52 yr at...
The aim of the study was to investigate heterogeneity temporal patterns vasomotor symptoms (VMS) over menopausal transition and identify factors associated with these in a diverse sample women.The Study Women's Health Across Nation is multisite longitudinal women from five racial/ethnic groups transitioning through menopause. analytic included 1,455 nonsurgical menopause median follow-up 15.4 years. Temporal VMS associations serum estradiol follicle-stimulating hormone, race/ethnicity, body...
Menopause may augment age-dependent increases in arterial stiffness, with black women having greater progression midlife compared white women. We sought to determine whether and when experience changes stiffness relative the final menstrual period (FMP) these differ between Approach Results: evaluated 339 participants from SWAN (Study of Women's Health Across Nation) Heart Ancillary study Nation). Women had ≤2 carotid-femoral pulse-wave velocity (cfPWV) exams over a mean±SD 2.3±0.5 years...
To better understand how to educate patients and providers about study findings relevant treatment guidelines, we assessed pre- versus post-Women's Health Initiative (WHI) differences in menopausal hormone therapy (MHT) initiation continuation their correlates, women's reasons for discontinuation.We analyzed survey data from up 14 approximately annual visits over 17 years (1996-2013) 3,018 participants the Study of Women's Across Nation, a prospective cohort study. We used logistic...
Background Cardiovascular disease (CVD) in women has unique features, including associations with reproductive factors that are incompletely understood. Vasomotor symptoms (VMS), the classic menopausal symptom, linked to CVD risk and subclinical CVD. Evidence linking VMS events is limited. We tested whether frequent and/or persistent were associated increased for fatal nonfatal SWAN (Study of Women's Health Across Nation). Methods Results A total 3083 women, aged 42 52 years at baseline,...
We examined the safety and efficacy of a combination intravesical oral pentosan polysulfate sodium in comparison to only treating interstitial cystitis.A total 41 females diagnosed with cystitis were randomized receive plus (21 treatment group) or placebo (20 for 6 weeks. All subjects continued another 12 The primary outcome was change O'Leary-Sant Interstitial Cystitis Symptoms/Problem Index from baseline week 6, 12, 18. Other outcomes included: changes Pelvic Pain Urgency Frequency...
To examine associations between vasomotor symptoms and lipids over 8 years, controlling for other cardiovascular risk factors, estradiol, follicle-stimulating hormone.Study of Women's Health Across the Nation participants (N=3,201), aged 42-52 years at entry, completed interviews on frequency hot flushes night sweats (none, 1-5 days, 6 days or more, in past 2 weeks) physical measures (blood pressure, height, weight), blood draws (low-density lipoprotein [LDL], high-density [HDL],...
Cardiovascular risk increases in women after menopause. Mounting evidence demonstrates a role of cardiovascular fat (CF) the pathogenesis coronary heart disease, but no research has examined CF relation to sex hormones or menopausal status women.The objective was determine relationship between depots, status, and endogenous hormones.Cross-sectional longitudinal study designs were used.The setting included Study Women's Health Across Nation (SWAN) Heart Fat Ancillary Study.A total 456 (mean...
The purpose of this study was to assess associations between distinct patterns circulating estradiol (E2) and follicle-stimulating hormone (FSH) over the menopause transition (MT) subclinical measures atherosclerosis after menopause. Four temporal E2 decline (Low: low before final menstrual period (FMP); Medium: medium high FMP; High-early decline: prior FMP early thereafter; High-late late thereafter) three FSH rise (Low, Medium, High) 9.6 years across were identified linked carotid...
The aim of this study was to determine whether postmenopause status is associated with self-reported limitations in physical function.The Study Women's Health Across the Nation a multisite, multiethnic, longitudinal midlife women. Women aged 45 57 years (N = 2,566) completed function scale Medical Outcomes Short-Form 36 on visit 4 (2000-2001). Scores created three-category variable limitations: none (86-100), moderate (51-85), and substantial (0-50). In Nation, menopause five-category list...
Background and Purpose— Emerging work has linked menopausal vasomotor symptoms (VMS) to subclinical cardiovascular disease (CVD) among women. However, VMS are dynamic over time. No studies have considered how temporal patterns of may relate CVD. We tested assessed 13 years were related carotid intima media thickness (IMT) midlife Methods— The Study Women’s Health Across the Nation is a longitudinal cohort study Eight hundred eleven white, black, Hispanic, Chinese participants with...