A5088717816- Antimicrobial Resistance in Staphylococcus
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Orthopedic Infections and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Dermatology and Skin Diseases
- Pancreatic and Hepatic Oncology Research
- Advances in Oncology and Radiotherapy
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Global Cancer Incidence and Screening
- Antimicrobial Peptides and Activities
- Innovations in Medical Education
- Liver physiology and pathology
- Systemic Sclerosis and Related Diseases
- Urinary and Genital Oncology Studies
- Viral-associated cancers and disorders
- Calcium signaling and nucleotide metabolism
- Atherosclerosis and Cardiovascular Diseases
- Nursing Roles and Practices
- Neuroendocrine Tumor Research Advances
- Bacterial biofilms and quorum sensing
- COVID-19 and healthcare impacts
Cleveland Clinic
2015-2025
New York University
2024
Johns Hopkins University
2019-2023
Johns Hopkins Medicine
2019-2023
University of Baltimore
2023
Royal Navy
2018
Cleveland Clinic Lerner College of Medicine
2018
The risk of COVID-19 infection is increased in patients with systemic lupus erythematosus (SLE) versus those without SLE. Some immunosuppressive medications increase and decrease the efficacy vaccination. Consensus documents have suggested management strategies for handling to vaccine efficacy, but benefit such has not been proven. current study was undertaken determine effect drugs on response
A pan-caspase inhibitor, Q-VD-OPH, has therapeutic efficacy against preclinical methicillin-resistant Staphylococcus aureus skin infection.
Abstract In vivo bioluminescence imaging has been used to monitor Staphylococcus aureus infections in preclinical models by employing bacterial reporter strains possessing a modified lux operon from Photorhabdus luminescens . However, the relatively short emission wavelength of (peak 490 nm) limited tissue penetration. To overcome this limitation, gene for click beetle ( Pyrophorus plagiophtalamus ) red luciferase luc (with longer >600 wavelength), was introduced singly and combination...
Staphylococcus aureus is the leading cause of skin and soft tissue infections a major health burden due to emergence antibiotic-resistant strains. To address unmet need alternative treatments antibiotics, better understanding protective immune mechanisms against S. infection warranted. Here, we report that tumor necrosis factor (TNF) promoted protection in skin, which was mediated by bone marrow–derived cells. Furthermore, neutrophil-intrinsic TNF receptor (TNFR) signaling directed immunity...
Neoadjuvant systemic therapy (NAST) is a treatment option for intrahepatic cholangiocarcinoma (iCCA), though its impact on short-term oncologic outcomes and long-term survival remains relatively unknown.
Liver tolerance was initially recognized by the spontaneous acceptance of liver allografts in many species. The underlying mechanisms are not completely understood. However, transplant (LT) absolutely requires interferon (IFN)-γ, a rejection-associated inflammatory cytokine. In this study, we investigated rejection deficient IFN-γ receptor and reveal that graft is equipped with machineries capable counterattacking host immune response through mesenchyme-mediated control (MMIC) mechanism....
ABSTRACT Introduction Pancreatic ductal adenocarcinoma (PDAC) of the body/tail is notably different than PDAC in head pancreas. Surgery plus chemotherapy known to improve outcomes for all PDAC. The sequence this therapy well studied cancers yet has never been evaluated systematically relation distal pancreatectomy (DP). Methods Patients receiving DP and who received were included. compared neoadjuvant systemic (NAST) only, adjuvant (AST) both NAST + AST, total (TNT), defined as > 24 weeks...
Post-surgical implant-associated spinal infection is a devastating complication commonly caused by Staphylococcus aureus Biofilm formation thought to reduce penetration of antibiotics and immune cells, contributing chronic difficult-to-treat infections. A rabbit model posterior-approach surgery was created, in which bilateral titanium pedicle screws were interconnected plate at the level lumbar vertebra L6 inoculated with methicillin-resistant S.aureus (MRSA) bioluminescent strain. In vivo...
Abstract Orthopedic implant‐associated infection (OIAI) is a major complication that leads to implant failure. In preclinical models of Staphylococcus aureus OIAI, osteomyelitis and septic arthritis, interleukin‐1α (IL‐1α), IL‐1β, tumor necrosis factor (TNF) are induced, but whether they have interactive or distinctive roles in host defense unclear. Herein, S. OIAI model was performed mice deficient IL‐1α, TNF. Mice IL‐1β TNF (to lesser extent) not IL‐1α had increased bacterial burden at the...
The COVID-19 pandemic required rapid adaptation of multidisciplinary tumor board conferences to a virtual setting; however, there are little data describing the benefits and challenges using such platform.An anonymous quality improvement survey was sent participants meetings at large academic institution. Participants answered questions pertaining relative strengths weaknesses in-person settings.A total 335 responses (23.3% response rate) were recorded, 253 met inclusion criteria....
Myeloid-derived suppressor cells (MDSCs) are markedly increased in cancer patients and tumor-bearing mice promote tumor growth survival by inhibiting host innate adaptive immunity. In this study, we generated characterized MDSCs from murine-induced pluripotent stem (iPSCs). The iPSCs were co-cultured with OP9 cells, stimulated GM-CSF, became morphologically heterologous under co-culturing hepatic stellate cells. Allogeneic OVA-specific antigen stimulation demonstrated that iPS-MDSCs have a...
C-C motif chemokine receptor 2 (CCR2) is an important mediator of myeloid cell chemotaxis during inflammation and infection. Myeloid cells such as monocytes, macrophages, neutrophils contribute to host defense orthopedic implant-associated infections (OIAI), but whether CCR2-mediated involved remains unclear. Therefore, a Staphylococcus aureus OIAI model was performed by surgically placing orthopedic-grade titanium implant inoculating bioluminescent S. strain in knee joints wildtype (wt)...
Abstract Introduction Pancreatic acinar cell carcinoma (pACC) is a rare malignancy with unique clinical and molecular features. The role of chemotherapy in pACC management not well established. Methods National Cancer Database (NCDB) for was used. Cox regression used resected patients to identify significant overall survival (OS) predictors. Patients were then divided based on these risk factors into propensity‐matched group surgery versus + Kaplan–Meier analysis performed log‐rank tests...
Abstract As the leading cause of skin and soft tissue infections, Staphylococcus aureus is a major health burden continued threat to human due emergence antibiotic-resistance. Through this current study, we aimed better characterize protective immune mechanisms against S. infection identify novel targets for development host-directed immunotherapeutics as alternatives antibiotics. Tumor necrosis factor (TNF) master regulatory cytokine whose inhibition associated with increased risk...
This paper focuses on the need to build a solid foundation of skills which future maritime workforce can provide innovation and exploitation new technologies that Royal Navy requires. sits within wider strategic context national engineering shortage, reflected recently in EngineeringUK report: ‘The State Engineering 2018.’ The report forecasts as conservative estimate an average shortfall graduates (level 4+) 22,000, with impact Brexit upon these figures yet be determined (the UK relies...