A5065674324- Pancreatic function and diabetes
- Plant Diversity and Evolution
- Fern and Epiphyte Biology
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Lichen and fungal ecology
- Plant Water Relations and Carbon Dynamics
- Seed Germination and Physiology
- Plant tissue culture and regeneration
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Plant Ecology and Taxonomy Studies
- Diet, Metabolism, and Disease
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Botanical Research and Applications
- Pancreatic and Hepatic Oncology Research
- Click Chemistry and Applications
- Flowering Plant Growth and Cultivation
- Diabetes Treatment and Management
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Biochemical and Structural Characterization
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
University of California, Los Angeles
2023-2024
Loyola Marymount University
2019
Instituto Venezolano de Investigaciones Científicas
1996-2008
Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. As a result, Au(III) bioconjugation reagents enable selective labeling of moieties down to picomolar concentrations allow for rapid construction complex heterostructures from peptides, proteins, oligonucleotides. This showcases how chemistry can be interfaced with biomolecules lead range reactivities that are largely unmatched by classical organic tools.
Despite much effort, antibody therapies for Alzheimer’s disease (AD) have shown limited efficacy. Challenges to the rational design of effective antibodies include difficulty achieving specific affinity critical targets, poor expression, and aggregation caused by buried charges unstructured loops. To overcome these challenges, we grafted previously determined sequences fibril-capping amyloid inhibitors onto a camel heavy chain scaffold. These were designed cap fibrils tau, known form...
The aggregation of the 37-amino acid polypeptide human islet amyloid (hIAPP), as either insoluble or small oligomers, appears to play a direct role in death pancreatic β-islet cells type 2 diabetes. hIAPP is considered be one most amyloidogenic proteins known. quick leads formation toxic species, such oligomers and fibers, that damage mammalian (both rat cells). Whether this toxicity necessary for progression diabetes merely side effect disease remains unclear. If into on-path developing...
Recent experiments conducted in vitro have documented a marked difference the time course for D-[U-14C]glucose net uptake by pieces of pancreatic tissue versus isolated islets. The present study aimed, therefore, at assessing whether endocrine pancreas contributes to detectable extent overall 2-deoxy-2-[18F]fluoro-D-glucose (FDG) gland. For this purpose, radioactive content was compared that plasma, erythrocytes, liver, brain, hypophysis and parotid gland 3 min, 15 min 240 after intravenous...
Pancreatic islet xenotransplantation might conceivably be successfully achieved if the islets are placed in a device protecting them against immune rejection [1]. We were interested taking first step exploring this possibility using rat model. The present study was aimed at monitoring changes body weight and glycemia occurring streptozotocin-induced diabetic rats (STZ rats) transplanted with xenografted islets. Islets prepared from animals of same species strain an implantation selectively...
A new procedure for the immobilization of tumoral pancreatic islet cells to a two-dimensional microsupport is presented. Tumoral RINm5F line (0.7x10(6) cells/ml) were immobilized microcarriers (16.6 cm2/ml). Within 24 h culture, and as judged from number cells, their protein or insulin content, less than 10% escaped immobilization. The metabolic response D-glucose was well preserved, paired ratio between D-[U-14C] glucose oxidation D-[5-3H]glucose utilization being even significantly higher...
Dispersed rat pancreatic islet cells were cultured overnight in the presence of polystyrene two-dimensional microsupports. About 1.7-1.9x10(6) attached to microsupports (832 cm2) found display both an insulin content and secretory response D-glucose and/or theophylline comparable those otherwise free cells. It is proposed that advantage could be taken this approach study function a standardized number such