A5031541323- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Alzheimer's disease research and treatments
- Immune Cell Function and Interaction
- Mast cells and histamine
- Berberine and alkaloids research
- Tattoo and Body Piercing Complications
- Eosinophilic Disorders and Syndromes
- Traditional and Medicinal Uses of Annonaceae
- Receptor Mechanisms and Signaling
- Multiple Myeloma Research and Treatments
- T-cell and Retrovirus Studies
- Complement system in diseases
- Alkaloids: synthesis and pharmacology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Kruppel-like factors research
- Hematopoietic Stem Cell Transplantation
- BRCA gene mutations in cancer
- Genetics and Neurodevelopmental Disorders
- Acute Lymphoblastic Leukemia research
- Evolutionary Psychology and Human Behavior
- Pharmacological Receptor Mechanisms and Effects
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
Brown University
2020-2024
Rhode Island Hospital
2021-2024
Mount St. Mary's University
2019-2021
Western Sydney University
2016
The aggregation of the 37-amino acid polypeptide human islet amyloid (hIAPP), as either insoluble or small oligomers, appears to play a direct role in death pancreatic β-islet cells type 2 diabetes. hIAPP is considered be one most amyloidogenic proteins known. quick leads formation toxic species, such oligomers and fibers, that damage mammalian (both rat cells). Whether this toxicity necessary for progression diabetes merely side effect disease remains unclear. If into on-path developing...
ObjectiveBody dysmorphic disorder (BDD) entails a preoccupation with perceived appearance defect, which causes distress and/or functional impairment. The individual must also perform repetitive behaviours in response to these concerns (e.g., mirror checking, excessive grooming). Prior research has focused primarily on preoccupation, and have rarely been examined. As such, there is limited insight regarding how activities are by the sufferer. This study therefore examined individuals BDD...
e13703 Background: Individuals from minoritized communities receive less cancer screening, have higher stage at diagnosis, and experience death rates. Helping minority high school students find a pathway to enter college continue with advanced education training become leaders in treatment, research prevention may help reduce these inequities. Many public schools urban centers struggle STEM education. The Rhode Island Hospital / Legorreta Cancer Center Brown University partnered the Papitto...
While the bone marrow (BM) microenvironment is significantly remodelled in acute myeloid leukaemia (AML), molecular insight into AML-specific alterations has been historically limited by analysis of liquid aspirates rather than core biopsies that contain solid-phase BM stroma. We assessed effect anthracycline- and cytarabine-based induction chemotherapy on both haematopoietic non-haematopoietic cells directly using RNA-seq histological analysis. compared matched human at diagnosis 2 weeks...
To identify naturally occurring variants of IAPP capable inhibiting the aggregation human and protecting living cells from toxic effects IAPP.The loss insulin-producing β-cells overall progression type 2 diabetes appears to be linked formation (hIAPP, Islet Amyloid Polypeptide, amylin) amyloid in pancreas. Inhibiting initial hIAPP has potential slow, if not stop entirely, halt disease.To characterize aggregation.Synthetic was incubated with synthetic identified natural sources under...
Uncaria tomentosa, or Cat's Claw, is a large woody vine plant that indigenous to the Amazonian rain forest. The roots and bark of cat's claw have been used for 2000 years as an herbal remedy ailments ranging from chronic fatigue gastrointestinal inflammation, more recently anticancer remedy. To explore use Claw among women Peru, Global Women in STEM Program at Mount Saint Mary's University designed administered person survey explores socioeconomic factors, access healthcare, natural...
Abstract We have previously reported a novel metabolically stimulative function of the sigma-2 receptor, with stimulation glycolytic hallmarks; effects consistent pro-survival role and receptor upregulation in cancer cells. These include increased reductive capacity as indicated by MTT reduction, increase cellular ATP level, reduction basal ROS stabilization HIF-1α, human SK-N-SH neuroblastoma The was blocked antagonists, supporting mediation receptors. Here we further characterize this...