A5091046148- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Organoboron and organosilicon chemistry
- Sulfur-Based Synthesis Techniques
- Advanced biosensing and bioanalysis techniques
- Inorganic and Organometallic Chemistry
- Coordination Chemistry and Organometallics
- Crystallography and molecular interactions
- Advanced Synthetic Organic Chemistry
- Click Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Fluorine in Organic Chemistry
- Molecular Junctions and Nanostructures
- Nanomaterials for catalytic reactions
- Chemical Reactions and Isotopes
University of Bath
2014-2024
Science and Technology Facilities Council
2024
BioElectronics (United States)
2019
Biosensor (Italy)
2019
Johns Hopkins University
2018
Somerset Community College
2017
Clave (Brazil)
2017
Institut Européen des Membranes
2016
Université de Montpellier
2016
École Nationale Supérieure de Chimie de Montpellier
2016
A selective catalytic meta sulfonation of 2-phenylpyridines was found to occur in the presence (arene)ruthenium(II) complexes upon reaction with sulfonyl chlorides. The 2-pyridyl group facilitates formation a stable Ru-C(aryl) σ bond that induces strong para-directing effect. Electrophilic aromatic substitution proceeds chloride furnish sulfone at position chelating group. This new process offers access atypical regioselectivity for reactions involving chelation-assisted cyclometalation.
The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because this, necessity for elegant techniques enable selective C–H functionalization is vast. Early developments have led primarily C2 C3 because inherent reactivity pyrrole ring. Despite methods been developed on benzenoid moiety at C4, C5, C6, C7. This review focuses contributions made indoles other related heteroaromatics such as carbazoles.
Playing tag with MOFs: Zinc metal–organic frameworks pendant aldehyde and methoxy groups are prepared. The aldehyde-tagged MOF takes up 2,4-dinitrophenylhydrazine, reacting to form a hydrazone-functionalized which is crystallographically characterized. Use of both aldehyde- methoxy-functionalized dicarboxylates leads MOFs containing ligands, the can be selectively reacted.
The application of heterogeneous catalysis in conjunction with microreactor technology can facilitate a cleaner and scalable flow methodology for organic synthesis. In this tutorial review we present recent advances the design supported catalysts emerging synthetic applications within technology. Specifically, transition metal such as palladium, copper, ruthenium, nickel are described on silica, monolithic, magnetic nanoparticles polymer supports. These have been utilised to promote range...
Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. As a result, Au(III) bioconjugation reagents enable selective labeling of moieties down to picomolar concentrations allow for rapid construction complex heterostructures from peptides, proteins, oligonucleotides. This showcases how chemistry can be interfaced with biomolecules lead range reactivities that are largely unmatched by classical organic tools.
Covering: 1st May 1995 to 31st March 2000.
A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range tertiary halides is described. The protocol simple to perform and uses commercially available reagents construct challenging quaternary carbon centres in regioselective manner. Preliminary studies suggest the proceeds through radical process directed via remote σ-activation.
The site-selective functionalization of an indole template offers exciting possibilities for the derivatization molecules with useful biological properties. Herein, we report remote C6-selective C–H alkylation derivatives enabled by dual cyclometalation/redox ruthenium catalysis. Remote was achieved using N-pyrimidinyl indoles ancillary ester directing group at C3 position. This proved pivotal to reactivity C6, yields up 92% achieved. A one-pot procedure install this followed C6 has also...
A novel ferrocene-derived substrate for the ratiometric electrochemical detection of alkaline phosphatase (ALP) was designed and synthesised. It demonstrated to be an excellent ALP-labelled enzyme-linked immunosorbent assay (ELISA).
Abstract The para ‐selective C−H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction proposed to take place via an N−H‐activated cyclometalate formed in situ. Experimental and DFT mechanistic studies elucidate dual role the ruthenium catalyst. Here catalyst can undergo cyclometalation by N−H metalation (as opposed meta processes) form redox active species, enable site‐selective radical addition at position.
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity scope 27 examples in 2-MeTHF. Yields ranged from 23 to 94%, producing highly decorated oxazolidinone A kinetically relevant cleavage also observed kinetic isotope effect (KIE) ∼2. Density functional theory calculations provided information about mechanism, detailing β-hydride elimination as most energetically challenging step...
Indium triflate is shown to be an extremely efficient catalyst for the acylation of alcohols and amines.
Enantiomerically pure ligands containing a 4,5-dihydrooxazole moiety tethered to an auxiliary sulfur or phosphorus donor have been prepared. These exploited for palladium-catalysed asymmetric allylic substitution, providing enantioselectivities of 40–96% ee. The origin the enantioselectivity in catalytic reaction is discussed terms steric and electronic influences provided by ligand.
A series of sulfur-tagged zinc MOFs containing functionalised 4,4'-biphenyldicarboxylate ligands has been prepared: oxidative post-synthetic modification with dimethyldioxirane converted the sulfide tags into sulfones, leaving MOF networks intact.
Four Lewis acidic silver phosphane complexes partnered with [1-closo-CB(11)H(12)](-) and [1-closo-CB(11)H(6)Br(6)](-) have been synthesised studied by solution NMR solid-state X-ray diffraction techniques. In the complex [Ag(PPh(3))(CB(11)H(12))] (1), is coordinated carborane two stronger 3c-2e B-H-Ag bonds, one weaker interaction a very weak Ag.C(arene) contact in solid state. solution, remains closely connected [Ag(PPh(3))](+) fragment, as evidenced (11)B chemical shifts. Complex 2...
Indium(III) salts have received considerable attention as Lewis acids in recent years. Their stability to co-ordinating atoms present organic substrates makes them excellent catalysts substoichiometric quantities. Stability water allows aqueous recycling and often the use of a reaction solvent. This review will focus on describing new developments application indium synthetic chemistry. Transformations that be covered include aromatic functionalisation, cycloaddition reactions, conjugate...
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTCommunity Sewage Sensors for Monitoring Public HealthZhugen Yang*†‡, Barbara Kasprzyk-Hordern†, Christopher G. Frost*†, Pedro Estrela‡, and Kevin V. Thomas§View Author Information† Department of Chemistry, University Bath, Claverton Down, BA2 7AY, U.K.‡ Electronic Electrical Engineering, U.K.§ Norwegian Institute Water Research (NIVA), Gaustadalléen 21, 0349 Oslo, Norway*E-mail: [email protected]. Tel.: +44 (0)1225 386 071. Fax: 231.*E-mail: 142....
A ruthenium-catalyzed C–H acylation of arylpyrazoles with a variety acyl chlorides is described. The reaction exhibits good regioselectivity and both aromatic aliphatic can be effectively coupled to the at ortho-position.