A5013668952- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Head and Neck Surgical Oncology
- Angiogenesis and VEGF in Cancer
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Nerve Disorders
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Neurosurgical Procedures and Complications
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Spinal Dysraphism and Malformations
- Neuroscience and Neural Engineering
- Cell Adhesion Molecules Research
- Ophthalmology and Eye Disorders
- EEG and Brain-Computer Interfaces
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- Surgical Simulation and Training
Azienda Ospedaliera San Gerardo
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2024
University of Milano-Bicocca
2007-2024
Institute of Materials, Minerals and Mining
2024
University of Milan
2007-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2014
Johns Hopkins Hospital
2013
The University of Texas MD Anderson Cancer Center
2013
National Institute of Mental Health and Neurosciences
2013
OBJECTIVE Subcortical stimulation can be used to identify functional language tracts during resection of gliomas located close or within areas pathways. The objective the present study was investigate feasibility routine use subcortical for identification in a large series patients with and determine influence that tract exerted on extent surgery appearance immediate definitive postoperative deficits. METHODS systematically surgical removal 88 (44 high-grade 44 low-grade gliomas) involving...
Axonal injury is believed to be a major determinant of adverse outcomes following traumatic brain injury. However, it has been difficult assess acutely the severity axonal in human patients. We hypothesized that microdialysis-based measurements extracellular fluid levels tau and neurofilament light chain, two low molecular weight proteins, could helpful this regard. To test hypothesis, 100 kDa cut-off microdialysis catheters were placed 16 patients with severe at neurological/neurosurgical...
Febrile infection-related epilepsy syndrome (FIRES) is a severe epileptic encephalopathy with presumed inflammatory origin and lacking effective treatments. Anakinra the human recombinant interleukin 1 receptor antagonist clinically used in autoinflammatory or autoimmune conditions. We report case of FIRES for which spatial temporal match between electroencephalography (EEG) magnetic resonance imaging (MRI) focal alterations provides support detrimental synergic interplay seizures...
Neuroimaging differentiation of glioblastoma, primary central nervous system lymphoma (PCNSL) and solitary brain metastasis (BM) remains challenging in specific cases showing similar appearances or atypical features. Overall, advanced MRI protocols have high diagnostic reliability, but their limited worldwide availability, coupled with the overlapping neuroimaging features among tumor subgroups, represent significant drawbacks entail disparities planning management these oncological...
Clival lesions pose significant challenges with regard to their surgical management. The expanded endoscopic endonasal (EEE) approach is a promising minimally invasive technique for of the central skull base. authors' aim in current paper was discuss treatment clival and present technical details, indications, limitations EEE approach. Data from recent endoscopically treated group will be compared findings previous cohort patients via classic open anterior lateral approaches.Since June 2005,...
Medical and surgical management of low-grade gliomas (LGGs) is complicated by a highly variable clinical course. The authors recently developed preoperative scoring system to prognosticate outcomes progression survival in cohort patients treated at single institution (University California, San Francisco [UCSF]). objective this study was validate the large patient group drawn from multiple external institutions.Clinical data 3 outside institutions Utah, Toronto Western Hospital, University...
Low-grade gliomas ([LGGs] WHO Grade II) are slow-growing intrinsic cerebral lesions that diffusely infiltrate the brain parenchyma along white matter tracts and almost invariably show a progression toward malignancy. The treatment of these tumors forces neurosurgeon to face uncommon difficulties is still subject debate. At authors' institution, resection first option in LGGs. It requires combined efforts multidisciplinary team neurosurgeons, neuroradiologists, neuropsychologists,...
The role of progenitor/stem cells in pituitary tumorigenesis, resistance to pharmacological treatments and tumor recurrence is still unclear. This study investigated the presence non‐functioning tumors (NFPTs) tested efficacy dopamine receptor type 2 (DRD2) somatostatin (SSTR2) agonists inhibit vitro proliferation. They found that 70% 46 NFPTs formed spheres co‐expressing stem cell markers, transcription factors (DAX1, SF1, ERG1) gonadotropins. Analysis behavior showed formation was...
Circulating platelets (PLTs) are able to affect glioblastoma (GBM) microenvironment by supplying oncopromoter and pro-angiogenic factors. Among these mediators, sphingosine-1-phophate (S1P) has emerged as a potent bioactive lipid enhancing cell proliferation survival. Here, we investigated the effect of “tumor education”, characterizing PLTs from GBM patients in terms activation state, protein content, potential. healthy donors (HD-PLTs) (GBM-PLTs) were collected, activated, analyzed flow...
An assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of morphology MRI characteristics. 74 BraTS-Toolkit DeepBraTumIA automatic segmentations, 42 neurosurgeon manual were accordingly evaluated. Brats-Toolkit generally provide accurate particularly for the most common round-shaped or well-demarked tumors, where: (1) segmentation correctly includes necrosis contrast enhanced in 100%...
Abstract The clinoidal segment of the internal carotid artery (ICA) is a complex transition zone between intracavernous and intradural spaces. It bordered by distal dural ring (DDR), proximal (PDR), anterior clinoid process (ACP). This study provides an endoscopic anatomical analysis region using endonasal approach (EEA) transorbital (ETOA). Ten cadaveric head specimens were dissected at Laboratory Surgical Neuroanatomy University Barcelona. EEA exposes medial region, revealing connection...
Abstract Glioblastomas represent an important cause of cancer-related mortality with poor survival. Despite many advances, the mean survival time has not significantly improved in last decades. New experimental approaches have shown tumor regression after grafting neural stem cells and human mesenchymal into intracranial gliomas adult rodents. However, cell source seems to be limitation for autologous transplantation glioblastoma. In present study, we evaluated targeting antitumor activity...
Background and purpose The aim of this study was to define the prevalence characteristics peri‐electrode edema in a prospective cohort patients undergoing deep brain stimulation ( DBS ) surgery correlate it with clinical findings. Methods We performed magnetic resonance imaging MRI between 7 20 days after 19 consecutive for Parkinson's disease. T2‐weighted hyperintensity surrounding leads characterized quantified. Any evidence bleeding around also evaluated. Clinical follow‐up data were...