A5101942502- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Adrenal and Paraganglionic Tumors
- Thyroid Disorders and Treatments
- Global Financial Crisis and Policies
- Genetics, Aging, and Longevity in Model Organisms
- Nutrition and Health in Aging
- Birth, Development, and Health
- RNA modifications and cancer
- Frailty in Older Adults
- Prostate Cancer Treatment and Research
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Economic Theory and Policy
- interferon and immune responses
- Respiratory Support and Mechanisms
- Monetary Policy and Economic Impact
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
University of Milan
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
IRCCS Istituto Auxologico Italiano
2015-2024
University of Naples Federico II
2000-2022
Magna Graecia University
2022
University of Modena and Reggio Emilia
2020
Istituto di Biometeorologia
2017
Centre Hospitalier Universitaire de Toulouse
2016
University of Bologna
2014
European Central Bank
2001-2013
The discovery of biomarkers able to predict biological age individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from small cohort 64 subjects different ages, we identified 3 regions, CpG islands ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age. These results were confirmed by Sequenom's EpiTYPER assay larger 501 9...
The outcome of 24 months cabergoline treatment on prolactin (PRL) normalization, tumor shrinkage, restoration pituitary function, and semen alterations was prospectively investigated in 41 men with macro- (age 17–70 yr) 10 microprolactinoma 18–53 yr). Fifty-one age-matched served as controls for analysis. At study entry, the patients macroprolactinoma, 17 (41.4%) had visual field defects, 14 (34.1%) headache, eight (19.5%) galactorrhea, 22 (53.6%) hypopituitarism apart from hypogonadism, 30...
Mitochondrial stress elicits the production of response molecules indicated as mitokines, including fibroblast growth factor 21 (FGF21), differentiation 15 (GDF15), and humanin (HN). Many diseases are characterized by progressive mitochondrial dysfunction with alterations mitokine secretion. It is still controversial whether healthy aging extreme longevity accompanied an altered mitokines. We analyzed FGF21, HN, GDF15 plasma levels in 693 subjects aged from to 113 years, association these...
Aging | doi:10.18632/aging.100715. Maria Giulia Bacalini, Davide Gentilini, Alessio Boattini, Enrico Giampieri, Chiara Pirazzini, Cristina Giuliani, Elisa Fontanesi, Scurti, Daniel Remondini, Miriam Capri, Guido Cocchi, Alessandro Ghezzo, Alberto Del Rio, Donata Luiselli, Giovanni Vitale, Daniela Mari, Gastone Castellani, Mario Fraga, Anna Di Blasio, Stefano Salvioli, Claudio Franceschi, Paolo Garagnani
The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread and the age-related high lethality.We observed a two-month of 40%, compared 6.4% previous year. This increase was seen both positive (43%) negative (24%) residents, but 8 patients among those testing on swab, tested serological tests. Increased associated with male gender, older age, no vitamin D supplementation worse "activities daily living (ADL)" scores, such as Barthel index, Tinetti scale...
We designed a prospective multicenter randomized controlled study in three long-term weaning units (LWU) to evaluate which protocol, inspiratory pressure support ventilation (PSV) or spontaneous breathing trials (SB), is more effective patients with chronic obstructive pulmonary disease (COPD) requiring mechanical for than 15 d. Fifty-two of 75 patients, failing an initial T-piece trial at admission, were randomly assigned PSV SB (26 both groups). No significant difference was found success...
To characterize mitral and aortic valve abnormalities we performed M-mode, two-dimensional, pulsed Doppler echocardiography in 42 patients with active acromegaly, 22 cured of 64 controls pair-matched the for sex age. The overall prevalence was higher both (86% vs. 24%; P < 0.0001) (73% 9%; than controls. Left ventricular hypertrophy (81% 29%; 0.0001), but not (41% 14%; = 0.09) Cardiac were associated left controls, without any difference between them. Conversely, among subjects...
Sympathetic activation induced by cold pressor test or cigarette smoking is accompanied a marked reduction of radial artery distensibility. It not known, however, whether arterial distensibility under tonic sympathetic restraint, this restraint involves arteries greater than the one in both normal and pathological conditions.We studied continuous ultrasonographic assessment changes diameter over diasto-systolic pressure range (finger measurement) eight patients with Dupuytren disease before...
The GH/IGF-I axis has a relevant role to play in the cardiovascular system but its implication pathogenesis of hypertension normal population and acromegaly is not yet clear.The aim this retrospective controlled study was evaluate prevalence determinants 200 patients with nonacromegalic subjects, matched for sex, age, body mass index (BMI) smoking habits.Hypertension found 46% 25% controls (P < 0.0001), without any difference between men women. Family history occurred 30% hypertensive...
We present a prospective study on the long-term efficacy of percutaneous ethanol injection (PEI) treatment large series symptomatic thyroid cystic nodules (STCN). Ninety-eight patients (72 females and 26 males) were treated. The mean basal volume STCN was 35.3 mL. In 92 98 PEI induced greater than 50% nodule shrinkage, only 6 responder relapsed at follow-up 9 years. Moreover, all had significant clinical benefit because reduction cyst-associated symptoms recorded. Furthermore, limited number...
Acromegaly is an infrequent disease attributable to endogenous excess of GH and IGF-I. Human studies have associated the GH-IGF-I axis with development colorectal cancer; however, question whether cancer a problem in acromegaly currently unresolved. We performed cross-sectional study assess risk colonic neoplasia patients acromegaly. Colonoscopic screening was 235 at five tertiary care hospitals Italy between January 1, 1996, December 31, 2001. A repeat colonoscopy 121 after mean interval...
In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality.To investigate relationships between levels, blood pressure (BP), glucose tolerance (GT).Four-hundred four subjects (200 men aged 18-80 years).personal history pituitary or diseases; previous current treatments drugs interfering BP, GT, lipids, corticosteroids (>2 weeks), estrogens, testosterone (>12 weeks); smoking >15 cigarettes/day alcohol abuse (>3 glasses wine/day).Two...
Aging | doi:10.18632/aging.100484. Giovanni Vitale, Michael P Brugts, Giulia Ogliari, Davide Castaldi, Letizia M. Fatti, Aimee J. Varewijck, Steven W. Lamberts, Daniela Monti, Laura Bucci, Elisa Cevenini, Francesco Cavagnini, Claudio Franceschi, Leo J Hofland, Mari, Joseph A.M.J.L. Janssen
Abstract Epigenetic remodeling is one of the major features aging process. We recently demonstrated that DNA methylation ELOVL2 and FHL2 CpG islands highly correlated with age in whole blood. Here we investigated several aspects age-associated hypermethylation FHL2. showed significantly different primary dermal fibroblast cultures from donors ages. Using epigenomic data public resources, most tissues show age. Interestingly, was not found very low replication rate. associated vitro cell...