A5006779696- Circadian rhythm and melatonin
- Mental Health Research Topics
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Building Energy and Comfort Optimization
- Sleep and related disorders
- Urban Green Space and Health
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Impact of Light on Environment and Health
- Digital Mental Health Interventions
- Psychiatric care and mental health services
- Transcranial Magnetic Stimulation Studies
- Sleep and Wakefulness Research
- Education, Healthcare and Sociology Research
- Functional Brain Connectivity Studies
- Health, psychology, and well-being
- Mental Health and Psychiatry
- Cardiac Health and Mental Health
- Olfactory and Sensory Function Studies
- Child and Adolescent Psychosocial and Emotional Development
- Psychological and Temporal Perspectives Research
University of Copenhagen
2016-2025
Copenhagen University Hospital
2013-2024
Mental Health Services
2011-2024
Capital Region of Denmark
2024
Frederiksberg Hospital
2024
Rigshospitalet
2012-2021
Dansk Sygehus Institut
2021
The Capital Region Pharmacy
2019-2021
Psychiatric Medicine Associates
2018
University of Washington
2018
Background. We have developed the Major Depression Inventory (MDI), consisting of 10 items, covering DSM-IV as well ICD-10 symptoms depressive illness. aimed to evaluate this a scale measuring severity states with reference both internal and external validity. Method. Patients representing score range from no depression marked on Hamilton Scale (HAM-D) completed MDI. Both classical modern psychometric methods were applied for evaluation validity, including Rasch analysis. Results. In total,...
The Major Depression Inventory (MDI) was developed to cover the universe of depressive symptoms in DSM-IV major depression as well ICD-10 mild, moderate, and severe depression. objective this study evaluate standardization MDI a severity scale using Visual Analogue Scale (VAS) index external validity accordance with LEAD approach (Longitudinal Expert Assessment All Data). We used data from two previously published studies which patients had MINI Neuropsychiatric Interview verified diagnosis...
Light is necessary for vision; it enables us to sense and perceive our surroundings in many direct indirect ways, via eye skin, affects physiological psychological health. The use of light built environments has comfort, behavioural, economic environmental consequences. Daylight particular benefits including excellent visual performance, permitting good eyesight, effective entrainment the circadian system as well a number acute non-image forming effects important role vitamin D production....
Daylight stems solely from direct, scattered and reflected sunlight, undergoes dynamic changes in irradiance spectral power composition due to latitude, time of day, year the nature physical environment (reflections, buildings vegetation). Humans their ancestors evolved under these natural day/night cycles over millions years. Electric light, a relatively recent invention, interacts competes with light–dark cycle impact human biology. What are consequences living industrialised urban areas...
Article AbstractObjective: The onset of action antidepressants often takes 4 to 6 weeks. antidepressant effect wake therapy (sleep deprivation) comes within hours but carries a risk relapse. objective this study was investigate whether new chronotherapeutic intervention combining with bright light and sleep time stabilization could induce rapid sustained augmentation response remission in major depressive disorder.Method: 75 adult patients DSM-IV disorder, recruited from psychiatric wards,...
Objective: Bright light treatment is an established for Seasonal Affective Disorder, but in non‐seasonal depression research results have been contrasting. Method: This study was designed as a 5‐week controlled, double‐blind, parallel trial out‐patients with diagnosis (DSM‐IV) of major depression, randomized to either active (white light, 10 000 lux, 1 h daily) or placebo (red 50 30 min and concomitant sertraline both groups. Results: One hundred two patients were included the study....
This study investigated the health effects of two different architectural glass types: A two-layered low-iron high transmittance and a three-layered low energy with lower transmittance. The how these types affected daylight conditions in 72 residential apartments, as well satisfaction residents.
This paper describes findings from a workshop during which participants evaluated series of window views. An explorative approach was applied to identify issues and testing methods useful in daylight research. The visited nine rooms with views varied content, complexity, viewing distance under the overcast sky. Participants used surveys quantitative qualitative questions, hand drawings, illuminance measurements, photography appraise view quality. Subsequently, simulations neurocognitive...
Background: Exposures from the indoor environment can cause multiple annoyances that might increase risk of depression. This study examines association between perceived at home and incident Methods: cohort is based on data 16,688 individuals (aged ≥16 years) who participated in Danish Health Morbidity Survey year 2000. Perceived levels (few, moderate, many) were information noise, low light levels, odor, thermal discomfort environment. Individuals followed up to 19 years after inclusion...
Objective: To investigate the use of bright light therapy as an adjunct treatment to sertraline in non‐seasonal major depression. Method: In a randomised double‐blind trial, 102 patients were treated for 5 weeks with either white (10 000 lux, 1 h daily) or red dim (50 30 min daily). All fixed dose 50 mg daily. The clinician‐rated depression scales used Hamilton Depression Rating Scale (HAM‐D 17 ), six‐item subscale 6 Melancholia (MES) and seven ‘atypical’ items from SIGH‐SAD. Results:...
Background. We set out to examine the psychometric properties of MDI in comparison BDI a mixed group patients with primary depression. Methods. At Department Biological Psychiatry Vienna currently depressed inpatients either depressive or schizo-affective disorder filled both and on day admission at time-point two weeks later during their treatment. Furthermore Hamilton Depression Scale (HAM-D) was administered by treating clinician time-points. Results. In total, 51 were included study. The...
Background This paper reports day-to-day data for from a one-week intervention phase, part of 9-weeks randomised parallel study with patient having major depression (data weekly visits have been reported). Wake therapy (sleep deprivation) has an established antidepressant effect onset action within hours. Deterioration on the following night's sleep is, however, common, and we used daily light time stabilisation as preventive measure. In particular, evaluated acute tolerance to deprivation...
<b><i>Background and Aim:</i></b> Improvement in patients admitted to inpatient wards with severe depression is slow, such are often discharged residual symptoms which put them at risk for relapse. New treatments that can speed up recovery highly desired. This naturalistic follow-up study a specialized affective disorders unit investigated the impact of daylight on length hospital stay improvement depression. <b><i>Methods:</i></b> For period 1...
Objective To investigate the long-term antidepressant effect of a chronotherapeutic intervention. Method In this randomized controlled trial 75 patients with major depression were allocated to fixed duloxetine and either intervention (wake group) three initial wake therapies, daily bright light therapy, sleep time stabilization or group using exercise. Patients followed 29 weeks. We report last 20 weeks, follow-up phase, where medication could be altered. assessed every 4 Remission rates...
The MONARCA I and II trials were negative but suggested that smartphone-based monitoring may increase quality of life reduce perceived stress in bipolar disorder (BD). present trial was the first to investigate effect on rate duration readmissions BD.This a randomized controlled single-blind parallel-group trial. Patients with BD (ICD-10) discharged from hospitalization Mental Health Services, Capital Region Denmark 1:1 daily including feedback loop (+ standard treatment) or treatment for 6...
Objective: We have tested the relapse‐preventive effect of citalopram when compared with placebo in 282 patients Seasonal Affective Disorder (SAD) responding to 1 week light therapy. Method: The response rate 1‐week therapy and relapse during continuation phase 15 weeks were assessed by use Hamilton Depression Rating Scale (HAM‐D 17 ), six‐item subscale 6 Melancholia (MES), combined HAM‐D/SIGH‐SAD. Results: was 62.5% on HAM‐D , 56.1% HAM‐D/SIGH‐SAD, 52.8% MES. In phase, found superior all...
Abstract We compared the quality of life (QOL) older adults in a post‐communist country (the Czech Republic) with those living traditional western democracies. The sample comprised 1981 respondents aged 60+ (from 60 to 99). subjective QOL was measured using WHOQOL‐BREF and add‐on module for adults, WHOQOL‐OLD. findings showed higher score depressive symptoms by GDS scale lower as other centres. Analyses factors related similar patterns centres depression emerging strongest determinant...
Background: Patients suffering from depression have a high risk of relapse and readmission in the weeks following discharge inpatient wards. Electronic self-monitoring systems that offer patient-communication features are now available to daily support patients, but usability, acceptability, adherence these has only been sparsely investigated. Objective: We aim test adherence, clinical outcome newly developed computer-based electronic self-assessment system (the Daybuilder system) patients...