Helle Østergaard Madsen
A5015517386- Circadian rhythm and melatonin
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Psychological and Temporal Perspectives Research
- Urban Green Space and Health
- Sleep and Wakefulness Research
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Retinal and Optic Conditions
- Dietary Effects on Health
- Health Promotion and Cardiovascular Prevention
- Eating Disorders and Behaviors
- Functional Brain Connectivity Studies
- Clinical practice guidelines implementation
- Impact of Light on Environment and Health
- Atherosclerosis and Cardiovascular Diseases
- Multiple Sclerosis Research Studies
- Emergency and Acute Care Studies
- Vitamin D Research Studies
- Glycosylation and Glycoproteins Research
- Glaucoma and retinal disorders
- Tryptophan and brain disorders
- Protease and Inhibitor Mechanisms
- Health, psychology, and well-being
- Mental Health Treatment and Access
Copenhagen University Hospital
2012-2024
Frederiksberg Hospital
2024
Rigshospitalet
2006-2021
Mental Health Services
2018-2021
University of Copenhagen
2009-2016
Svendborg Sygehus
1995
Copenhagen Municipal Hospital
1974
Summary Objectives To determine health care provider cost and household of the treatment severe pneumonia in infants young children admitted to secondary tertiary level facilities. Methods The study was done a private, not‐for‐profit medical college hospital, Vellore, India, mid‐2008. Children aged 2–36 months with no underlying chronic disease were included study. relatives interviewed daily on matters relating patients’ view point costs. These direct costs, non‐medical costs which...
<b><i>Background and Aim:</i></b> Improvement in patients admitted to inpatient wards with severe depression is slow, such are often discharged residual symptoms which put them at risk for relapse. New treatments that can speed up recovery highly desired. This naturalistic follow-up study a specialized affective disorders unit investigated the impact of daylight on length hospital stay improvement depression. <b><i>Methods:</i></b> For period 1...
Abstract Background Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In previous exploratory study patients bipolar I disorder, we found that history suicide attempts was differences between winter summer levels solar insolation. The purpose this to confirm finding using international data from 42% more collection sites 25% countries. Methods Data analyzed were 71 prior new in 40 countries at wide range latitudes. analysis included 4876 45% than...
An account is given of a multinational double‐blind trial, in which the tetracyclic antidepressant maprotiline (Ludiomil®) was compared with amitriptyline. Two hundred and eleven patients participated; these 191 completed trial. In 68% cases, endogenous depression diagnosed; remaining cases were diagnosed as reactive or other depressions. Hamilton's Rating Scale for Depression used, unwanted effects registered on standardized scales. No statistically significant difference antidepressive...
Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses these can be evaluated pupillometry. study aimed to assess light induced pupil constriction patients with bipolar disorder (BD).We investigated pupillary chromatic pupillometry 31 newly diagnosed disorder, 22 their unaffected relatives 35 healthy controls. Mood state was...
Background: Persistent cognitive impairment is frequent across bipolar disorder (BD) and major depressive (MDD), highlighting an urgent need for pro-cognitive treatments. Aim: This study investigated effects of erythropoietin (EPO) on dorsal prefrontal cortex (dPFC) activity in affective disorders. Methods: In this randomized, double-blinded, placebo-controlled trial, cognitively impaired patients with remitted BD or MDD received 1 weekly recombinant human EPO (40,000 IU/mL) saline infusion...
Abstract Objective: Seasonal and non-seasonal depression are prevalent conditions in visual impairment (VI). We assessed the effects side of light therapy persons with severe VI/blindness who experienced recurrent depressive symptoms winter corresponding to seasonal affective disorder (SAD) or subsyndromal SAD (sSAD). Results: included 18 (11 VI, 3 perception 4 no perception) met screening criteria for sSAD/SAD a single-arm, assessor-blinded trial 6 weeks therapy. In 12 completed treatment,...
Aim In glaucoma, depression and disturbed sleep has been associated with degeneration of the intrinsically photosensitive retinal ganglion cells, that mediate non-image forming effects light such as regulation circadian rhythm, alertness mood. this study we assessed associations between seasonal mood behavior variation cell damage in outpatients glaucoma. Methods The pattern assessment questionnaire was administered to Data on visual field defects identified by autoperimetry nerve fiber...
Primary open angle glaucoma is associated with an increased risk of mood and sleep disorders. These adversities have been suggested to relate a disrupted function the intrinsically photosensitive retinal ganglion cells (ipRGCs). The ipRGCs are key components in nonvisual photoreceptive system that mediates light effects on mood, circadian rhythm. We assessed diurnal hormone levels, pupillary responses under seasons different photoperiods 24 patients age- sex-matched healthy controls...
People with seasonal affective disorder (SAD) experience recurrent fluctuations in energy, mood and appetite. Retinal light exposure is suggested to play an important role the pathogenesis treatment of SAD. The aim study determine prevalence SAD persons severe visual impairments or blindness compare results a control group without impairments. Moreover, authors wish investigate whether correlated degree impairment diagnosis.2781 ranging from total Snellen acuity 6/60 receive information...
Abstract Background The rate of suicide attempts by patients with bipolar disorder is high. In addition to patient and country specific factors, environmental factors may contribute suicidal behavior. Sunlight has multiple diverse impacts on human physiology Solar insolation defined as the electromagnetic energy from sun striking a surface area earth. We previously found that large change in solar between minimum maximum monthly values was associated an increased risk I disorder. Methods...
Introduction Retrospective studies conducted in psychiatric inpatient wards have shown a relation between the intensity of daylight patient rooms and length stay, pointing to an antidepressant effect ambient lighting conditions. Light therapy has promising when administered from light box. The emergence light-emitting diode (LED) technology made it possible build luminaires into dynamically mimic spectral temporal distribution daylight. objective this study is investigate efficacy newly...
Abstract Background Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) do not receive enough UVB winter to produce D. This exploratory study investigated association between age onset bipolar I disorder threshold for sufficient a large global sample. Methods Data 6972 patients with were obtained 75...
Chronotherapeutic interventions for bipolar depression and mania are promising associated with rapid response benign side effect profiles. Filtering of biologically active short wavelength (blue) light by orange tinted eyewear has been shown to induce antimanic sleep promoting effects in inpatient mania. We here describe a study protocol assessing acute long-term stabilizing blue blocking (BB) glasses outpatient treatment disorder.