A5060404260- Dermatologic Treatments and Research
- Nonmelanoma Skin Cancer Studies
- Skin Protection and Aging
- Digital Mental Health Interventions
- Infectious Diseases and Mycology
- Hair Growth and Disorders
- Virtual Reality Applications and Impacts
- Photodynamic Therapy Research Studies
- Cutaneous lymphoproliferative disorders research
- Mental Health Research Topics
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Substance Abuse Treatment and Outcomes
- Advancements in Transdermal Drug Delivery
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Electroconvulsive Therapy Studies
- melanin and skin pigmentation
- Nail Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Child and Adolescent Psychosocial and Emotional Development
- Facial Rejuvenation and Surgery Techniques
- Neuroscience of respiration and sleep
- Bipolar Disorder and Treatment
- Neuroendocrine regulation and behavior
- Cancer and Skin Lesions
Mental Health Services
2023-2024
Capital Region of Denmark
2023-2024
Center for Clinical & Basic Research
2020
University of Copenhagen
2011-2017
Bispebjerg Hospital
2014-2017
Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is effective for thin actinic keratoses (AKs) in field-cancerized skin. Ablative fractional laser resurfacing (AFXL) creates vertical channels that facilitate MAL uptake and may improve PDT efficacy.To evaluate efficacy safety of AFXL-assisted (AFXL-PDT) compared conventional field-directed treatment AK.Fifteen patients a total 212 AKs (severity grade I-III) skin the face scalp were randomized to one AFXL-PDT two symmetrical...
Photodynamic therapy (PDT) is approved for selected nodular basal cell carcinomas (nBCC) but efficacy reduced large and thick tumours. Ablative fractional lasers (AFXL) facilitate uptake of methyl aminolaevulinate (MAL) may thus improve PDT outcome.To evaluate safety AFXL-mediated (AFXL-PDT) compared with conventional high-risk nBCC.Patients histologically verified facial nBCC (n = 32) defined as tumours were included; diameter > 15 mm, located in zones, or on severely sun-damaged skin....
Background and Objective Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after exposure remains be established. aim study, was investigate the importance time‐related topical application relate resultant skin with channel morphology integrity. Study Design/Materials Methods Buttock healthy volunteers ( n = 11) exposed 10,600 nm...
Background and Objectives Laser treatment in the early phases of wound healing may reduce scar formation. However, little is known on when laser exposure most optimally should be provided at which fluence levels. This study investigates clinical effect non‐ablative‐fractional‐laser (NAFL) performed three time points a range levels versus untreated control scars. Materials Methods A randomized, controlled, intra‐individual trial with erbium‐glass 1,540 nm NAFL no sixteen subjects receiving 10...
Background and Objective Intense pulsed light (IPL) is a mainstream treatment for hair removal. Side effects after IPL are known, but risk factors remain to be investigated. The objective of this study was assess the contribution skin pigmentation, fluence level, ultraviolet radiation (UVR) on IPL‐induced side effects. Methods blinded, randomized intra‐individual controlled trial including 16 healthy subjects with Fitzpatrick Skin Types (FST) II–V. Three test areas were each divided into...
The MONARCA I and II trials were negative but suggested that smartphone-based monitoring may increase quality of life reduce perceived stress in bipolar disorder (BD). present trial was the first to investigate effect on rate duration readmissions BD.This a randomized controlled single-blind parallel-group trial. Patients with BD (ICD-10) discharged from hospitalization Mental Health Services, Capital Region Denmark 1:1 daily including feedback loop (+ standard treatment) or treatment for 6...
Introduction Alcohol use disorder (AUD) is a brain linked to over 200 health conditions. Cognitive behavioural therapy (CBT) considered the best practice in treatment of AUD, but more than 60% patients relapse within first year after treatment. Psychotherapy combined with virtual reality (VR) has received increasing interest AUD. However, existing studies have primarily investigated VR for cue reactivity. We therefore aimed investigate effect VR-assisted CBT (VR-CBT). Methods and analysis...
Background At-home laser and intense pulsed-light hair removal continues to grow in popularity availability. A relatively limited body of evidence is available on the course growth during after low-fluence usage. Objectives To assess growing counts, thickness colour quantitatively cessation treatment. Methods Thirty-six women with skin phototypes I–IV light dark-brown axillary hairs were included. Entire regions randomized zero or eight self-administered weekly treatments an 810-nm home-use...
Introduction Cognitive behavioral therapy (CBT) is an evidence-based treatment for alcohol use disorder (AUD). Exposure to high-risk situations in virtual reality (VR) has been suggested have a potential therapeutical benefit, but no previous study combined VR and CBT AUD. We aimed investigate the feasibility of using VR-simulated environments CBT-based Methods randomized ten treatment-seeking AUD-diagnosed individuals three sessions conventional or VR-assisted performed at two outpatient...
Background and Objective Photodynamic therapy (PDT) is associated with erythema edema. Photobiomodulation (PBM) may stimulate the skin recovery process. We investigated potential of PBM to reduce PDT‐induced reactions. Study Design Methods Healthy volunteers ( n = 20) were randomized receive left‐ or right side (near‐infrared 839/595 nm) placebo‐PBM (595 on their buttocks. Corresponding test areas exposed standardized PDT reactions, using ablative fractional laser‐assisted (AFXL‐PDT)...
The risk of adverse skin effects following light-based hair removal is greater in pigmented based on the theory selective photothermolysis. Thus sunlight-induced pigment i.e., facultative pigmentation, increases effects, perhaps disproportionately. aim this study was to evaluate influence constitutive and pigmentation low-fluence intense pulsed light (IPL)-induced effects.Twenty-one subjects with Fitzpatrick type II-IV were enrolled. Two buttock blocks randomized receive 0 or 8 solar...
Background and Aim Ingenol mebutate (IngMeb) is an effective treatment for actinic keratosis. In this study, we hypothesized that repeated treatments with IngMeb may prevent progression of UV-induced photodamage, concurrent application a corticosteroid reduce IngMeb-induced local skin responses (LSR). Methods Hairless mice (n = 60; 3 groups 20 mice) were irradiated solar simulated ultraviolet radiation (UVR) throughout the study. Five single given at 4-week intervals (Days 21, 49, 77, 105,...