A5041212876- Nonmelanoma Skin Cancer Studies
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Wound Healing and Treatments
- NF-κB Signaling Pathways
- Asthma and respiratory diseases
- Melanoma and MAPK Pathways
- Ethics in Clinical Research
- MicroRNA in disease regulation
- Skin Protection and Aging
- Biomedical Ethics and Regulation
- Fungal Plant Pathogen Control
- Cutaneous Melanoma Detection and Management
- Social Media in Health Education
- Infectious Diseases and Mycology
- Health Systems, Economic Evaluations, Quality of Life
- Cytokine Signaling Pathways and Interactions
- Oral Health Pathology and Treatment
- Biosimilars and Bioanalytical Methods
- Mobile Health and mHealth Applications
- Pharmaceutical industry and healthcare
- Patient-Provider Communication in Healthcare
Leo Pharma (Denmark)
2011-2020
Leo Pharma (Australia)
2014-2015
University of Copenhagen
2009-2010
Gentofte Hospital
2007-2010
Psoriasis is a systemic disease with cutaneous manifestations. MicroRNAs (miRNAs) are small non-coding RNA molecules that differentially expressed in psoriatic skin; however, only few cell- and region-specific miRNAs have been identified lesions. We used laser capture microdissection (LCM) next-generation sequencing (NGS) to study the specific miRNA expression profiles epidermis (Epi) dermal inflammatory infiltrates (RD) of skin (N = 6). 24 deregulated Epi 37 RD plaque compared normal (FCH >...
The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor and more stable analogue FOL-026. X-ray diffraction microscale thermophoresis analysis revealed that FOL-026 shares binding site with VEGF in NRP-1 b1-subdomain. Stimulation of human umbilical vein cells resulted phosphorylation VEGFR-2,...
Abstract Squamous cell carcinoma (SCC) is the second most common human skin cancer and leading cause of cancer–related death. Recently, a new compound, ingenol mebutate, was approved for treatment actinic keratosis, precursor SCC. As mechanism action poorly understood, we have further investigated mebutate–induced We elucidate direct effects mebutate on primary keratinocytes, patient-derived SCC cells, line. Transcriptional profiling followed by pathway analysis performed mebutate–treated...
Remote monitoring was used to assess and manage skin diseases.To investigate what extent smartphone photographs along with a self-reported body region (BR) score can be evaluate psoriasis severity.Psoriasis severity assessed in the clinic using area index physician's global assessment. On same day, patients took photograph of representative lesion from 4 BR (head/neck, upper limbs, trunk, lower limbs) completed questionnaire about score. The were rated by 5 dermatologists. Intraclass...
Gene transfer by electroporation (DNA electrotransfer) to muscle results in high level long term transgenic expression, showing great promise for treatment of e.g. protein deficiency syndromes. However little is known about the effects DNA electrotransfer on fibres. We have therefore investigated transcriptional changes through gene expression profile analyses, morphological histological analysis, and physiological force generation measurements. was obtained using a combination short voltage...
Dysregulated angiogenesis is a hallmark of chronic inflammatory diseases, including psoriasis, common skin disorder that affects approximately 2% the population. Studying both human psoriasis in 2 complementary xenotransplantation models and psoriasis-like lesions transgenic mice with epidermal expression TGF-β1, we have demonstrated antiangiogenic non-viral somatic gene therapy reduces cutaneous microvasculature alleviates disorders. Transient muscular recombinant disintegrin domain (RDD)...
The use of photographs to diagnose and monitor skin diseases is gaining ground.To investigate the validity reliability photographic assessments atopic dermatitis (AD) severity.AD severity was evaluated in clinic by two assessors using Eczema Area Severity Index (EASI), SCOring Atopic Dermatitis (SCORAD), Investigator's Global Assessment (IGA). Participants photographed lesions with their own smartphone completed a questionnaire about extent eczema same day from home. were assessed twice an 8...
Patient satisfaction is an important indicator of health care quality, and it remains goal for optimal treatment outcomes to reduce the level misdiagnoses inappropriate or absent therapeutic actions. Digital support tools differential diagnosis assist clinicians in reaching correct may be helpful, but how use these affect patients not clear. The primary objective this feasibility study was investigate patient experience a setting where general practitioners (GPs) used visual clinical...
The rapid and strong clinical efficacy of the first-in-class, ingenol mebutate, against actinic keratosis (AK) has resulted in its recent approval. We conducted first comprehensive analysis cellular molecular mode action topical mebutate 0.05% gel both AK uninvolved skin 26 patients a phase I, single-center, open-label, within-patient comparison. As early as 1 day after application, induced profound epidermal cell death, along with infiltrate CD4+ CD8+ T-cells, neutrophils, macrophages....
Introduction Clinical trials often suffer from significant recruitment barriers, poor adherence, and dropouts, which increase costs negatively affect trial outcomes. The aim of this study was to examine whether making it virtual reward-based would enable nationwide recruitment, identify patients with variable disease severity, achieve high reduce dropouts. Methods In a siteless, feasibility study, individuals atopic dermatitis (AD) were recruited online. During the 8-week subjects used their...
Increasing costs and complexity in clinical trials requires recruitment of more narrowly defined patient populations. However, for remains a considerable challenge.Our overall aim was to quantify performance industry-sponsored phase III conducted globally during 2008-2019 with primary examine development trial measures (number completed, number participants enrolled, duration months) key metrics (recruitment rate, sites, patients enrolled per site).The publicly available AACT database...
There is a lack of efficacious topical treatments for patients suffering from psoriatic nail disease (PND). We investigated the efficacy Calcipotriol-Betamethasone Dipropionate (Cal/BD) foam with and without ablative fractional laser (AFL) in PND. A total 144 nails 11 were treated 24-week long, open-label, randomized, intra-patient controlled proof-of-concept hybrid trial. In addition to daily Cal/BD application, half each patient's randomized receive optical coherence tomography...
Diphencyprone (DPCP) is a hapten that induces delayed-type hypersensitivity (DTH) reactions. MicroRNAs (miRNAs) are short non-coding RNAs negatively regulate gene expression and have been implicated in various inflammatory skin diseases, but their role DTH reactions not well understood. We generated global miRNA profiles (using next-generation sequencing) of DPCP seven healthy volunteers at 3, 14 120 days after challenge. Compared to placebo-treated sites, DPCP-challenged 3 (peak...
Background Digital imaging of dermatological patients is a novel approach to remote assessment and has recently become more relevant since telehealth decentralized clinical trials are gaining ground. Objective We aimed investigate whether photographs taken by smartphone adequate quality allow severity assessments be made explore the usefulness an established atopic dermatitis instrument on photograph evaluation. Methods During scheduled visits in previously published study, investigating...
Patient recruitment is a major cause of delays in randomized controlled trials (RCT). Online evolving into an alternative to conventional in-clinic for RCT. The objective this study was test the effectiveness online patient RCT on actinic keratosis (AK). In proof-of-concept study, adults with AK were recruited Phase I/IIa (NCT05164393) via social media using targeted advertising Interested users directed landing page learn about respond questionnaires, and upload self-obtained smartphone...