A5062580424- Optical Coherence Tomography Applications
- Dermatologic Treatments and Research
- Nonmelanoma Skin Cancer Studies
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- Systemic Sclerosis and Related Diseases
- Surgical Sutures and Adhesives
- Autoimmune Bullous Skin Diseases
- Dermatological diseases and infestations
- Entomological Studies and Ecology
- Antimicrobial Resistance in Staphylococcus
- Nail Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Indoor Air Quality and Microbial Exposure
- Sarcoidosis and Beryllium Toxicity Research
- bioluminescence and chemiluminescence research
- Dupuytren's Contracture and Treatments
- Neuroendocrine regulation and behavior
- Syphilis Diagnosis and Treatment
- Pharmaceutical studies and practices
- Antimicrobial agents and applications
- Allergic Rhinitis and Sensitization
Bispebjerg Hospital
2016-2020
University of Copenhagen
2012-2019
The University of Queensland
2016-2017
Princess Alexandra Hospital
2017
Translational Research Institute
2017
Roskilde Sygehus
2012-2015
To explore the application of optical coherence tomography (OCT) imaging basal cell carcinomas (BCC) and actinic keratosis (AK) before, during after imiquimod treatment ability OCT to predict outcome.The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients OCT-scanned 1 4 weeks 3 months. Lesions identified clinically OCT. Thickness morphology lesions recorded at each visit. Any remaining biopsied follow-up.Complete data sets available for 16 (8 women 8 men aged...
Background and Objective Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after exposure remains be established. aim study, was investigate the importance time‐related topical application relate resultant skin with channel morphology integrity. Study Design/Materials Methods Buttock healthy volunteers ( n = 11) exposed 10,600 nm...
Background and Objective Optical coherence tomography (OCT) reflectance confocal microscopy (RCM) offer high‐resolution optical imaging of the skin, which may provide benefit in context laser‐assisted drug delivery. We aimed to characterize postoperative healing ablative fractional laser (AFXL)‐induced channels dynamics their spatiotemporal closure using vivo OCT RCM techniques. Study design/Materials Methods The inner forearm healthy subjects ( n = 6) was exposed 10,600 nm CO 2 5 25%...
In recent years, various lasers have increasingly been applied during wound healing to minimize scar formation. However, no consensus regarding treatment procedures exists. To assess formation clinically after three nonablative fractional laser (NAFL) exposures, targeting the inflammation, proliferation and remodelling phases in patients vs. untreated controls. A randomized controlled trial was performed using a split‐wound design excisional halves treated with 1540‐nm NAFL treatment. Three...
Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis dermatomyositis. Although there are several advantages using capillaroscopy, method does not offer insight on skin architecture, flow status, or morphology deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection high-speed changes back-scattered light caused moving cells The high...
Collagen deposition disorders such as hypertrophic scars, keloids and scleroderma can be associated with significant stigma embarrassment. These often constitute considerable impairment to quality of life, treatment posing a substantial challenge. Optical coherence tomography (OCT) provides non-invasive, easily applicable bedside optical imaging method for assessment the skin. It is hypothesized that OCT may useful in assessing fibrosis avoid additional biopsies could potentially worsen...
Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe changes in skin morphology due scabies infestation and visualize parasite.Five patients from Departments of Dermatology, Augsburg, Germany, Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites identified by epiluminescence light microscopy confirm diagnosis.OCT S. mites all vivo. burrows visualized, some detail on burrow...
Background Ablative fractional laser (AFXL) is an acknowledged technique to increase uptake of topical agents in skin. Micro thermal ablation zones (MAZs) consist ablated vertical channels surrounded by a coagulation zone (CZ). Laser scanning confocal microscopy (LSCM) images individual MAZs at 733 nm (reflectance (RCM)). Further, LSCM can image sodium fluorescein (NaF) fluorescence with 488 excitation (fluorescence microcopy (FCM)), small hydrophilic test molecule (370 MW, log P ‐1.52),...
<b><i>Background:</i></b> Optical coherence tomography (OCT) is a non-invasive optical imaging technique providing high-resolution images. OCT may be useful as monitoring tool during treatment of actinic keratoses (AK) and skin cancer. <b><i>Objective:</i></b> To examine describe how morphology changes when the tissue exposed to effects cryotherapy. <b><i>Methods:</i></b> Normal ex vivo in AK lesions were examined....
Ablative fractional laser (AFL) increases uptake of topically applied skin agents. The coagulation zone (CZ) surrounding vertically ablated channels may influence drugs.To investigate impact CZ thickness on fluorescence intensities (FI) a hydrophilic molecule by means microscopy (FM) and confocal (FCM). Second, to compare FI lipophilic test molecules FCM.Microchannels with thicknesses 0, 20, 80 µm were generated microneedles or AFL (10,600 nm). Channels 700 deep number kept constant per...
Abstract Background Basal cell carcinomas ( BCC s) have previously been treated off‐label with ingenol mebutate IM ). Ablative fractional laser AFL ) may improve efficacy of by increasing drug uptake in the tumour. Optical coherence tomography OCT and reflectance confocal microscopy RCM detect non‐invasively. Our aim was to investigate response tolerability after combined treatment low‐risk s. Methods Twenty patients histologically verified superficial n = 7) nodular 13) s were CO 2 ‐laser...
Abstract Background Anogenital warts ( AGW ) can cause physical discomfort and decreased quality of life. Recent case reports suggest that ingenol mebutate gel might be an effective treatment . Objective To explore primarily the safety, secondarily efficacy 0.05% in patients with Methods This was exploratory, open‐label, 1‐arm trial administered up to three times Safety assessed by occurrence severity local skin reactions LSR s) treatment‐related adverse events AE s). Efficacy complete...
To investigate and compare the presentation of granulomatous lesions in optical coherence tomography (OCT) images this to previous studies nonmelanoma skin tumors.Two patients with granulomas, tophi granuloma annulare (GA), respectively, were photographed digitally, OCT-scanned biopsied said order. Normal was for comparison, but not biopsied. The OCT from each lesion compared their histologic as well similar characteristics obtained tumors.The showed hyperreflective, rounded cloud-like...
Background Staphylococcal scalded skin syndrome ( SSSS ) and toxic epidermal necrolysis TEN both present with acute onset, high morbidity significant mortality. Rapid diagnosis is therefore of importance. The aim this study was to investigate compare the presentation these diseases using optical coherence tomography OCT ). Methods Two male patients bullous diseases, , respectively, were photographed digitally, examined dermoscopy, scanned subsequently biopsied in said order. Results...
<b><i>Hintergrund: </i></b><i>Sarcoptes scabiei</i> kann mit Hilfe verschiedener Darstellungsverfahren sichtbar gemacht werden. Mit der optischen Kohärenztomographie (OCT) lassen sich möglicherweise die bei Skabies-Infestation auftretenden Veränderungen Hautmorphologie charakterisieren und Parasit darstellen. <b><i>Methoden:</i></b> Fünf Patienten aus Klinik für Dermatologie am Klinikum Augsburg Roskilde Hospital in Roskilde,...
Acrodermatitis continua Hallopeau (ACH) ist eine seltene, chronische, sterile, pustulöse Eruption, die hauptsächlich an den Fingerspitzen auftritt und auch Nägel betrifft. Während einige ACH als eigenständige Entität ansehen, gehen viele andere davon aus, dass es sich um Variante der Psoriasis pustulosa handelt, insbesondere weil ACH-Fälle mit Progression zu einer generalisierten (GPP) berichtet wurden. Kürzlich konnte gezeigt werden, rezessiv vererbte Mutationen im <i>IL36RN-</i>Gen, das...
Akne bei erwachsenen Frauen ist eine schwer zu behandelnde, häufige Erkrankung, der es oft Rezidiven kommt. Sie hat meist negative Auswirkungen auf die Lebensqualität und mit großen sozialen metabolischen Verlusten für Betroffenen verbunden. Bei vorliegenden Untersuchung handelt sich um transversale retrospektive Studie, folgende Ziele hatte: Standardisierung Untersuchungen den zirkulierenden Androgenkonzentrationen frühzeitiger Nachweis hyperandrogener Zustände, Häufigkeit das Muster...
Derzeit gibt es keine allgemein anerkannten Definitionen für Wunden mit erhöhtem Infektionsrisiko. In der klinischen Praxis wird bei zu vielen chronischen ein Infektionsrisiko gesehen, weshalb in großem Umfang - Bezug sowohl auf die Häufigkeit als häufig auch Dauer Anwendung topische antimikrobielle Wirkstoffe eingesetzt werden. Auf Grundlage von Expertengesprächen und dem aktuellen Erkenntnisstand wurde klinischer Beurteilungs-Score entwickelt. Ziel dieses Wounds-at-risk(W.A.R.)-Scores ist...
<b><i>Hintergrund/Ziel: </i></b>Moderne Männer haben veränderte Schönheitsideale und Körperpflegegewohnheiten, was zu einer erhöhten Nachfrage nach Kosmetika für geführt hat. Über die dermatologischen Bedürfnisse der männlichen Haut ist jedoch sehr wenig bekannt. Daher sollte mit dieser klinischen Studie erstmals eine systematische Untersuchung Hautphysiologie von Männern besonderem Augenmerk auf Veränderungen im Laufe des Lebens durchgeführt werden. <b><i>Methoden: </i></b>Insgesamt wurden...
<b><i>Hintergrund:</i></b> Pegyliertes liposomales Doxorubicin (PLD) ist ein hochwirksames Chemotherapeutikum, das jedoch bei bis zu 80% der Patienten dermale Nebenwirkungen wie z.B. eine palmar-plantare Erythrodysästhesie (PPE) hervorruft - wahrscheinlich, indem es mit dem Schweiß auf die Hautoberfläche austritt. <b><i>Ziel:</i></b> Das Ziel dieser Studie war untersuchen, ob topisch applizierte Salbe, Antioxidanzien einem hohen Radikalschutzfaktor enthält, Auftreten PPE verhindern vermag....
Körperpflegeprodukte, die Berichten zufolge eine allergische Kontaktdermatitis auf das darin enthaltene Formaldehyd verursachen, müssen angesichts der jüngsten chemischen Entwicklungen in unserem Verständnis des Filmbildners Toluolsulfonamid-Formaldehyd-Harz, Konservierungsstoffe Diazolidinylharnstoff und Imidazolidinylharnstoff sowie Formalin neu bewertet werden. Der vorliegende Artikel beleuchtet diese Stoffe Verwendung von Rohmaterialien formaldehydhaltigen Konservierungsstoffen...