A5069075055- Dermatologic Treatments and Research
- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- Optical Coherence Tomography Applications
- Laser Applications in Dentistry and Medicine
- Nail Diseases and Treatments
- Photoacoustic and Ultrasonic Imaging
- Nonmelanoma Skin Cancer Studies
- Advancements in Transdermal Drug Delivery
- Optical Imaging and Spectroscopy Techniques
- Wound Healing and Treatments
- Tattoo and Body Piercing Complications
- Acne and Rosacea Treatments and Effects
- Advanced Fluorescence Microscopy Techniques
- Cutaneous Melanoma Detection and Management
- Body Contouring and Surgery
- Ocular and Laser Science Research
- melanin and skin pigmentation
- Laser Material Processing Techniques
- Peatlands and Wetlands Ecology
- Cancer and Skin Lesions
- Heme Oxygenase-1 and Carbon Monoxide
- Spectroscopy Techniques in Biomedical and Chemical Research
- Facial Rejuvenation and Surgery Techniques
- Nanoplatforms for cancer theranostics
Massachusetts General Hospital
2016-2025
Harvard University
2015-2024
Brigham and Women's Hospital
2020
Society For Investigative Dermatology
2020
Military Health System
2020
The Royal Melbourne Hospital
2017-2020
St Vincent’s Private Hospital Sydney
2020
Shriners Hospitals for Children - Boston
2019
Massachusetts Institute of Technology
2004-2016
Harvard–MIT Division of Health Sciences and Technology
2004-2016
Suitably brief pulses of selectively absorbed optical radiation can cause selective damage to pigmented structures, cells, and organelles in vivo. Precise aiming is unnecessary this unique form injury because inherent thermal properties provide target selectivity. A simple, predictive model presented. Selective cutaneous microvessels melanosomes within melanocytes shown after 577-nanometer (3 × 10 -7 second) 351-nanometer (2 -8 pulses, respectively. Hemodynamic, histological, ultrastructural...
Abstract Basic theoretical considerations of the optical and thermal transfer processes that govern damage induced in tissue by lasers are discussed. An approximate, predictive model data proposed for purpose selecting a laser maximizes to cutaneous blood vessels minimizes surrounding connective overlying epidermis. The variables wavelength, exposure duration, incident energy density modeled, flashlamp‐pumped dye operating at or near 577 nm absorption band HbO 2 , with pulsewidth (0.3 μsec)...
Abstract Background and Objective Fractional photothermolysis (FP) is a new concept using arrays of microscopic thermal damage patterns to stimulate therapeutic response. We analyzed epidermal dermal response FP with the aim correlating histological clinical Study Design/Materials Methods Twelve subjects received single treatment prototype diode laser emitting at wavelength 1,500 nm, delivering 5 mJ per zone (MTZ), density 1,600 MTZs/cm 2 on forearm. Biopsies were procured over period 3...
Abstract The action spectra for delayed erythema and melanogenesis in Caucasian human skin are determined wavelengths between 250 435 nm. untanned of very fair volunteers was observed after single exposures to a range fluences monochromatic radiation. At longer than 300 nm the two indistinguishable, at shorter nm, they similar shape despite distinct separation. This suggests common or chromophore initiation vascular pigmentary responses UV. A broad minimum occurs near 280 maximum 296...
Abstract Background and Objectives Ablative fractional resurfacing (AFR) creates vertical channels that might assist the delivery of topically applied drugs into skin. The purpose this study was to evaluate drug by CO 2 laser AFR using methyl 5‐aminolevulinate (MAL), a porphyrin precursor, as test drug. Materials Methods Two Yorkshire swine were treated with single‐hole subsequent topical application MAL (Metvix®, Photocure ASA, Oslo, Norway), placebo cream no MAL‐induced fluorescence...
Despite expert wound care and assiduous management with traditional therapy, poor cosmetic outcomes, restricted motion, symptoms such as pain itch are a pervasive problem of disfiguring debilitating scars. The advent ablative fractional photothermolysis within the past decade its application to treatment traumatic scars represents breakthrough in restoration function appearance for injured patients, but procedure is not widely used.To provide synthesis our current clinical experience...
We have built a video-rate confocal scanning laser microscope for reflectance imaging of human skin and oral mucosa in vivo. Design parameters were determined optimum resolution contrast. Mechanical skin-holding fixtures tissue clamps made stable objective lens-to-tissue contact such that gross motion relative to the was minimized. Confocal possible maximum depths 350 microm 450 mucosa, with measured lateral 0.5-1 axial (section thickness) 3-5 at 1064-nm wavelength. This is comparable...
Light reflected from skin has two components: regular reflectance, or "glare" arising the surface, and light backscattered within tissue. The reflectance contains visual cues related to surface texture, whereas component pigmentation, erythema, infiltrates, vessels, other intracutaneous structures. Unlike component, preserves plane of polarization polarized incident light. Thus, viewing through a linear polarizer, under linearly illumination, separates components tissue reflectance. Thirty...
<h3>Objective</h3> To test the hypothesis that picosecond laser pulses are more effective than nanosecond domain in clearing of tattoos. <h3>Design</h3> Intratattoo comparison trial 2 treatment modalities. <h3>Setting</h3> A large interdisciplinary biomedical laboratory on campus a tertiary medical center. <h3>Patients</h3> Consecutive patients with black tattoos were enrolled; all 16 completed study. <h3>Intervention</h3> We treated designated parts same tattoo 35-picosecond and...
<h3>Objective</h3> To compare the efficacy, adverse effects, and histological findings of erbium:YAG (Er:YAG) carbon dioxide (CO<sub>2</sub>) laser treatment in removing facial rhytides. <h3>Design</h3> An intervention study 21 subjects with All participants were followed up for 6 months. The end points wrinkle improvement duration effects. <h3>Setting</h3> Academic referral center. <h3>Subjects</h3> Nineteen female 2 male volunteers skin type I to III class participated study....
Background and Objectives In theory, infrared vibrational bands could be used for selective photothermolysis of lipid-rich tissues such as fat, sebaceous glands, or atherosclerotic plaques. Study Design/Materials Methods Absorption spectra human fat were measured, identifying promising near 1,210 1,720 nm. Photothermal excitation porcine dermis measured with a 3.5–5 µm thermal camera during exposure to the free electron laser (FEL) at Jefferson National Laboratory. Thermal damage...
Abstract— Spectral transmittance of 400–865 nm radiation through various human structures, including the skull with scalp, chest wall, abdominal wall and scrotum, is presented. There essentially no visible light wavelengths shorter than 500 transmitted or wall. In contrast, 10 −5 –10 −4 blue can reach brain testes. Transmittance all tissues increases progressively wavelength from 600 to 814nm. The maximal transmittances are −2 −1 for skulls scrota, −3 walls. Tissue thickness, optical...
Analytical modeling that interrelates the optical properties of multilayered structures is applied to skin. The mathematical approach based on relations diffuse reflectance and transmittance a system each component layer. formula can also be derived from Kubelka-Munk theory radiation transfer. Using both collimated incident irradiance, applicability model human epidermis over UV visible region has been verified. calculate absorption scattering coefficients in vitro, estimate epidermal under...
Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is effective for thin actinic keratoses (AKs) in field-cancerized skin. Ablative fractional laser resurfacing (AFXL) creates vertical channels that facilitate MAL uptake and may improve PDT efficacy.To evaluate efficacy safety of AFXL-assisted (AFXL-PDT) compared conventional field-directed treatment AK.Fifteen patients a total 212 AKs (severity grade I-III) skin the face scalp were randomized to one AFXL-PDT two symmetrical...
Abstract Despite steady improvement in the laser treatment of port wine stains (PWS), hypertrophic scarring remains a serious side‐effect approximately 10% patients. The tunable dye (577 nm) has been shown to cause selective vascular destruction normal and PWS skin. We have treated ten patients using nm, 300 m̈sec) resulting clearing without any evidence scarring. Treatment requires no anesthesia or wound care, there were postoperative infections.