A5048838123- Neurotransmitter Receptor Influence on Behavior
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Procter & Gamble (United States)
2014-2025
Procter & Gamble (Netherlands)
2025
Procter & Gamble (United Kingdom)
2013
Boston Medical Center
2000
Newcastle upon Tyne Hospital
2000
Case Western Reserve University
1987-1995
University of Liverpool
1995
Royal Liverpool University Hospital
1995
Purdue University West Lafayette
1984-1994
Yonsei University
1992
Abstract: In vivo microdialysis was used to determine whether the 3,4‐methylenedioxymethamphetamine (MDMA)‐induced release of serotonin (5‐HT) in involves a carrier‐mediated process and investigate further state‐dependent interaction between 5‐HT dopamine. MDMA produced dose‐dependent increase extracellular concentration striatum prefrontal cortex that attenuated by treatment with fluoxetine but not tetrodotoxin. Suppression MDMA‐induced accompanied suppression Administration rats treated...
The racemic mixture of 3,4-methylenedioxymethamphetamine (MDMA), which has been reported to produce selective destruction serotonergic neurons in the central nervous system, was studied determine its neuroendocrine and temperature effects mechanism action. MDMA elevated serum concentrations corticosterone doses ranging from 3 20 mg/kg administered i.p. Serum were 30 min after administration (10 i.p.) remained 4 hr later. prolactin (PRL) by 1 i.p., maximal 60 injection 10 declining rapidly...
The effects of the amphetamine analog, 3,4-methylenedioxymethamphetamine (MDMA) were compared to d-amphetamine on in vivo release dopamine and gamma-aminobutyric acid (GABA) striatum substantia nigra. brain region-dependent role 5-HT2 receptors nigra regulating MDMA-induced GABA also was studied. Changes extracellular concentration dopamine, 5-HT measured simultaneously awake rat by microdialysis. increase striatal produced systemic administration MDMA attenuated infusion TTX into striatum....
The effect of dopamine (DA) and serotonin (5-HT) uptake inhibitors on 3,4-methylenedioxymethamphetamine (MDMA)-induced increase in DA efflux was studied using vivo microdialysis. MDMA infused directly into the anterolateral striatum via dialysis probe. local administration produced a dose- time-dependent extracellular concentration striatum. Peripheral blockers, mazindol (5 mg/kg, i.p.) or GBR 12909 (10 i.p.), slight but significant DA. Moreover, pretreatment with either 30 min before...
• To examine further the serotoninergic system in obsessivecompulsive disorder (OCD), plasma concentrations of cortisol and prolactin behavioral responses after oral administration MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine), a serotonin agonist, placebo were studied 17 patients with OCD nine normal controls. The two groups did not differ significantly basal or levels. Nevertheless, both response to (20 mg) blunted compared those affect intensity symptoms. However, MK-212, as placebo,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A Potent Serotonin 5-HT2A/2C AgonistDavid E. Nichols, Stewart Frescas, Danuta Marona-Lewicka, Xuemei Huang, Bryan L. Roth, Gary A. Gudelsky, and J. Frank NashCite this: Med. Chem. 1994, 37, 25, 4346–4351Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December...