A5083921219- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- Cardiac Health and Mental Health
- Perfectionism, Procrastination, Anxiety Studies
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Infrared Thermography in Medicine
- Mental Health Treatment and Access
- Face Recognition and Perception
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Cardiac pacing and defibrillation studies
- Ultrasound and Hyperthermia Applications
- Schizophrenia research and treatment
- Identity, Memory, and Therapy
- Body Image and Dysmorphia Studies
- Intensive Care Unit Cognitive Disorders
University of Copenhagen
2016-2024
Glostrup Hospital
2018-2024
Mental Health Services
2023-2024
Capital Region of Denmark
2022-2024
Copenhagen University Hospital
2016-2024
Rigshospitalet
2016
Patients hesitate to consent electroconvulsive therapy (ECT) because of the fear memory impairment. The mechanisms underlying this impairment are unclear, but several observations suggest hippocampal alterations may be involved. We investigated whether ECT-induced change in volume correlates with impairment.Using a 3 T MRI scanner, we acquired brain images and assessed cognitive performance 22 severely depressed patients at three time points: (1) before ECT series, (2) within one week after...
<b><i>Background and Aim:</i></b> Improvement in patients admitted to inpatient wards with severe depression is slow, such are often discharged residual symptoms which put them at risk for relapse. New treatments that can speed up recovery highly desired. This naturalistic follow-up study a specialized affective disorders unit investigated the impact of daylight on length hospital stay improvement depression. <b><i>Methods:</i></b> For period 1...
The mechanisms underlying memory deficits after electroconvulsive therapy (ECT) remain unclear but altered functional interactions between hippocampus and neocortex may play a role. To test whether ECT reduces connectivity posterior regions of the default mode network (DMN) to examine hippocampal-neocortical correlates with impairment. A secondary aim was explore if these changes are present 6 months ECT. In-patients severe depression (n = 35) received bitemporal Functional probed...
Objective Several studies have found an increase in hippocampal volume following electroconvulsive therapy ( ECT ), but the effect on cortical thickness has been less investigated. We aimed to examine effects of and their associations with clinical outcome. Method Using 3 Tesla MRI scanner, we obtained T1‐weighted brain images 18 severely depressed patients at three time points: before, right after 6 months a series . The 68 regions was extracted using Free Surfer, Linear Mixed Model used...
S100B is a glial cell protein with bimodal function. In low concentrations, it exerts neurotrophic effects, but higher levels reflect neuronal distress. Recent research suggests that this molecule may be biomarker of response to electroconvulsive therapy (ECT). We examined the effect ECT on serum and its utility as 1) depressive state 2) predictor response. also wanted ensure does not cause marked elevation, indicating neural distress.We measured in 22 in-patients treated due depression....
Background Difficult-to-treat-depression (DTD) is a clinical challenge. The interventions that are well-established for DTD not suitable or effective all the patients. Therefore, more treatment options highly warranted. We formulated an evidence-based guideline concerning six in Denmark.Methods Selected review questions were according to PICO principle with specific definitions of patient population (P), intervention (I), comparison (C), and outcomes interest (O), systematic literature...
Electroconvulsive therapy (ECT) is one of the most effective and rapid-acting treatment for severe depression but associated with cognitive side-effects. Identification add-on treatments that counteract these side-effects would be very helpful. This randomized, double-blinded, placebo-controlled, parallel-group study investigated effects four erythropoietin (EPO; 40,000 IU/ml) or saline (placebo) infusions over 2.5 weeks ECT (eight sessions) in severely depressed patients unipolar bipolar...
The mechanisms underlying the antidepressant effect and cognitive side effects of Electroconvulsive Therapy (ECT) remain elusive. measurement cerebral perfusion provides an insight into brain physiology.We investigated ECT-related changes in depressed patients tested whether these correlate with clinical effects.A sample 22 in-patients was examined at three time points: 1) within two days before, 2) one week after, 3) six months after ECT series. Cerebral quantified using arterial spin...
Both Capgras syndrome and folie à deux (insanity of two) are rare fascinating psychopathological syndromes. Their etiology the nosological position remain unclear. We present a case substance-induced emerging as in monozygotic twins with strongly overlapping life histories. Then, we discuss these two conditions well their significance for understanding concept psychosis.
Background: The mechanisms underlying the antidepressant effect and cognitive side effects of Electroconvulsive Therapy (ECT) remain elusive. measurement cerebral perfusion provides an insight into brain physiology.Objective: We investigated ECT-related changes in depressed patients tested whether these correlate with clinical effects.Methods: A sample 22 in-patients was examined at three time points: 1) within two days before, 2) one week after, 3) six months after ECT series. Cerebral...