A5026310782- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Sleep and Work-Related Fatigue
- Spaceflight effects on biology
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Thermoregulation and physiological responses
- Impact of Light on Environment and Health
- Diet and metabolism studies
- Treatment of Major Depression
- Retinal Development and Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Psychological and Temporal Perspectives Research
- Neuroendocrine regulation and behavior
- Paranormal Experiences and Beliefs
- Heart Rate Variability and Autonomic Control
- Dietary Effects on Health
- Bipolar Disorder and Treatment
University of Basel
2012-2022
Universitäre Psychiatrische Kliniken Basel
2002-2022
National Institute of Mental Health
1979-2015
KU Leuven
2011-2013
University Hospital of Basel
1991-2013
University of Illinois Chicago
2013
University Psychiatric Hospital
1987-2011
Psychiatry Baselland
1986-2008
Institut Cochin
2002
Swinburne University of Technology
1996
Human behavior shows large interindividual variation in temporal organization. Extreme “larks” wake up when extreme “owls” fall asleep. These chronotypes are attributed to differences the circadian clock, and animals, genetic basis of similar phenotypic is well established. To better understand organization humans, authors developed a questionnaire document individual sleep times, self-reported light exposure, self-assessed chronotype, considering work free days separately. This report...
In the last three decades two-process model of sleep regulation has served as a major conceptual framework in research. It been applied widely studies on fatigue and performance to dissect individual differences regulation. The posits that homeostatic process (Process S) interacts with controlled by circadian pacemaker C), time-courses derived from physiological behavioural variables. simulates successfully timing intensity diverse experimental protocols. Electrophysiological recordings...
Light can elicit acute physiological and alerting responses in humans, the magnitude of which depends on timing, intensity, duration light exposure. Here, we report that response as well its effects thermoregulation heart rate are also wavelength dependent. Exposure to 2 h monochromatic at 460 nm late evening induced a significantly greater melatonin suppression than occurred with 550-nm light, concomitant increased core body temperature (∼2.8 × 1013 photons/cm2/sec for each treatment)....
Many people spend an increasing amount of time in front computer screens equipped with light-emitting diodes (LED) a short wavelength (blue range). Thus we investigated the repercussions on melatonin (a marker circadian clock), alertness, and cognitive performance levels 13 young male volunteers under controlled laboratory conditions balanced crossover design. A 5-h evening exposure to white LED-backlit screen more than twice as much 464 nm light emission {irradiance 0,241 Watt/(steradian ×...
Seven healthy men were studied in a 34-h constant routine protocol to investigate whether the daily rhythm of heat production and loss has an endogenous circadian component. Under these unmasking conditions (constant bed rest, no sleep allowed, regular food fluid intake), significant could be demonstrated for production, heart rate, skin temperatures but not respiratory quotient. Heat rate phase locked with maximum at 1100-1200 h. Proximal (infraclavicular region, thigh, forehead) followed...
Sleep in depressed patients resembles sleep normal subjects whose circadian rhythms of temperature and rapid-eye-movement are phase-advanced (shifted earlier) relative to their schedules. If this analogy is relevant the pathophysiology depressive illness, advancing time awakening should temporarily compensate for abnormal timing patients' rhythms. Four seven manic-depressive studied longitudinally spontaneously advanced times (activity onset) as they emerged from phase illness. In a...
PurposeAdolescents prefer sleep and wake times that are considerably delayed compared with younger children or adults. Concomitantly, multimedia use in the evening is prevalent among teenagers involves light exposure, particularly blue-wavelength range to which biological clock its associated arousal promotion system most sensitive. We investigated whether of blue light–blocking glasses (BB) during evening, while sitting front a light-emitting diode (LED) computer screen, favors initiating...
This study evaluates the efficacy of agomelatine, first antidepressant to be an agonist at MT(1)/MT(2) receptors and antagonist 5-HT(2C) receptors, versus sertraline with regard amplitude circadian rest-activity cycle depressive anxiety symptoms in patients major disorder (MDD).Outpatients DSM-IV-TR-defined MDD received either agomelatine 25 50 mg (n = 154) or 100 159) during a 6-week, randomized, double-blind treatment period. The was conducted from 2005 2006. main outcome measure relative...
Affective disorder during pregnancy is a common condition requiring careful judgment to treat the depression while minimizing risk fetus. Following up on promising pilot trials, we studied efficacy of light therapy.Twenty-seven pregnant women with nonseasonal major depressive according DSM-IV (outpatients, university polyclinic) were randomly assigned 7,000 lux fluorescent bright white or 70 dim red (placebo) administered at home in morning upon awakening for 1 h/d 5-week double-blind trial...
Light is necessary for vision; it enables us to sense and perceive our surroundings in many direct indirect ways, via eye skin, affects physiological psychological health. The use of light built environments has comfort, behavioural, economic environmental consequences. Daylight particular benefits including excellent visual performance, permitting good eyesight, effective entrainment the circadian system as well a number acute non-image forming effects important role vitamin D production....
Electroencephalogram (EEG) power density and self-rated fatigue were assessed in nine healthy women during a 40-hour period of sustained wakefulness under constant behavioral environmental conditions (constant routine protocol). Waking EEG recordings performed for 4 minutes after 3, 10, 27 34 hours prior wakefulness. the 6.25- to 9.0-Hz frequency range progressively increased across four recordings, suggesting an endogenous homeostatic component regulation theta/alpha frequencies conditions....
Thermoregulatory processes have long been implicated in initiation of human sleep. The purpose this study was to evaluate the role heat loss sleep initiation, under controlled conditions a constant-routine protocol modified permit nocturnal Heat indirectly measured by means distal-to-proximal skin temperature gradient (DPG). A stepwise regression analysis revealed that DPG best predictor variable for sleep-onset latency (compared with core body or its rate change, heart rate, melatonin...
Learning-dependent increases in sleep spindle density have been reported during nocturnal immediately after the learning session. Here, we investigated experience-dependent changes daytime EEG activity declarative of unrelated word pairs. At weekly intervals, 13 young male volunteers spent three 24 h sessions laboratory under carefully controlled homeostatic and circadian conditions. approximately midday, subjects performed either one two word-pair tasks or a matched nonlearning control...
Both the pineal hormone melatonin (Mel) and postural changes have thermoregulatory sequelae. The purpose of study was to evaluate their relationship subjective sleepiness. Eight healthy young men were investigated under unmasking conditions a constant routine protocol. Heart rate, rectal temperature (Tre), skin temperatures (foot, Tfo; stomach), sleepiness ratings continuously recorded from 1000 1700. Mel (5 mg po) administered at 1300, time when should not phase shift circadian system....