A5068124511- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Sleep and related disorders
- Sleep and Work-Related Fatigue
- Impact of Light on Environment and Health
- Noise Effects and Management
- Spaceflight effects on biology
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Air Quality and Health Impacts
- Vehicle Noise and Vibration Control
- Coffee research and impacts
- Photoreceptor and optogenetics research
- Dietary Effects on Health
- Olfactory and Sensory Function Studies
- Hearing Loss and Rehabilitation
- Thermoregulation and physiological responses
- Color perception and design
- Visual perception and processing mechanisms
- Diet and metabolism studies
- Psychological and Temporal Perspectives Research
- Ophthalmology and Visual Impairment Studies
- Tryptophan and brain disorders
- Cardiovascular and exercise physiology
- Climate Change and Health Impacts
University of Basel
2016-2025
Universitäre Psychiatrische Kliniken Basel
2010-2025
Lucerne University of Applied Sciences and Arts
2021
University Hospital of Basel
2013-2019
University of Illinois Chicago
2013
KU Leuven
2013
Swiss Archaeology
2012
University Psychiatric Hospital
2001-2006
Brigham and Women's Hospital
1997-2004
Harvard University
1997-2004
The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon phase at which exposure occurs. Previously reported human response curves (PRCs) single bright exposures have employed small sample sizes, and were often based on relatively imprecise estimates resetting. In present study, 21 healthy, entrained subjects underwent pre- post-stimulus constant routines (CRs) in dim (approximately 2-7 lx) with maintained wakefulness a...
Light can elicit acute physiological and alerting responses in humans, the magnitude of which depends on timing, intensity, duration light exposure. Here, we report that response as well its effects thermoregulation heart rate are also wavelength dependent. Exposure to 2 h monochromatic at 460 nm late evening induced a significantly greater melatonin suppression than occurred with 550-nm light, concomitant increased core body temperature (∼2.8 × 1013 photons/cm2/sec for each treatment)....
Many people spend an increasing amount of time in front computer screens equipped with light-emitting diodes (LED) a short wavelength (blue range). Thus we investigated the repercussions on melatonin (a marker circadian clock), alertness, and cognitive performance levels 13 young male volunteers under controlled laboratory conditions balanced crossover design. A 5-h evening exposure to white LED-backlit screen more than twice as much 464 nm light emission {irradiance 0,241 Watt/(steradian ×...
The circadian clock orchestrates many aspects of human physiology, and disruption this has been implicated in various pathologies, ranging from cancer to metabolic syndrome diabetes. Although there is evidence that metabolism the clockwork are intimately linked on a transcriptional level, whether these effects directly under control or mediated by rest–activity cycle timing food intake unclear. To answer question, we conducted an unbiased screen subjects metabolome blood plasma saliva at...
Background Light exposure can cascade numerous effects on the human circadian process via non-imaging forming system, whose spectral relevance is highest in short-wavelength range. Here we investigated if commercially available compact fluorescent lamps with different colour temperatures impact alertness and cognitive performance. Methods Sixteen healthy young men were studied a balanced cross-over design light of 3 settings (compact 40 lux at 6500K 2500K incandescent 3000K) during 2 h...
Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way...
PurposeAdolescents prefer sleep and wake times that are considerably delayed compared with younger children or adults. Concomitantly, multimedia use in the evening is prevalent among teenagers involves light exposure, particularly blue-wavelength range to which biological clock its associated arousal promotion system most sensitive. We investigated whether of blue light–blocking glasses (BB) during evening, while sitting front a light-emitting diode (LED) computer screen, favors initiating...
Summary Light in the short wavelength range (blue light: 446–483 nm) elicits direct effects on human melatonin secretion, alertness and cognitive performance via non‐image‐forming photoreceptors. However, impact of blue‐enriched polychromatic light sleep architecture electroencephalographic activity remains fairly unknown. In this study we investigated structure characteristics 30 healthy young participants (16 men, 14 women; age 20–31 years) following 2 h evening exposure to at 6500 K, 2500...
The aim of the present study is to establish exposure-response relationships reflecting percentage highly annoyed (%HA) as functions road traffic, railway, and aircraft noise exposure, measured day-evening-night level (Lden), well elucidate degree which acoustic indicator Intermittency Ratio (IR), reflects "eventfulness" a situation, predicts annoyance. We conducted mixed-mode representative population survey in stratified random sample 5592 residents exposed transportation all over...
The aim of this study was to quantify the associations between slow eye movements (SEMs), blink rate, waking electroencephalogram (EEG) power density, neurobehavioral performance, and circadian rhythm plasma melatonin in a cohort 10 healthy men during up 32 h sustained wakefulness. time course performance characterized by fairly stable levels throughout first 16 wakefulness followed deterioration phase secretion. This closely associated with an increase SEMs. Frontal low-frequency EEG...
Electroencephalogram (EEG) power density and self-rated fatigue were assessed in nine healthy women during a 40-hour period of sustained wakefulness under constant behavioral environmental conditions (constant routine protocol). Waking EEG recordings performed for 4 minutes after 3, 10, 27 34 hours prior wakefulness. the 6.25- to 9.0-Hz frequency range progressively increased across four recordings, suggesting an endogenous homeostatic component regulation theta/alpha frequencies conditions....
Thermoregulatory processes have long been implicated in initiation of human sleep. The purpose this study was to evaluate the role heat loss sleep initiation, under controlled conditions a constant-routine protocol modified permit nocturnal Heat indirectly measured by means distal-to-proximal skin temperature gradient (DPG). A stepwise regression analysis revealed that DPG best predictor variable for sleep-onset latency (compared with core body or its rate change, heart rate, melatonin...
Learning-dependent increases in sleep spindle density have been reported during nocturnal immediately after the learning session. Here, we investigated experience-dependent changes daytime EEG activity declarative of unrelated word pairs. At weekly intervals, 13 young male volunteers spent three 24 h sessions laboratory under carefully controlled homeostatic and circadian conditions. approximately midday, subjects performed either one two word-pair tasks or a matched nonlearning control...