A5045823387- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Obstructive Sleep Apnea Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Blood Pressure and Hypertension Studies
- Cognitive Abilities and Testing
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- COVID-19 and Mental Health
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Dementia and Cognitive Impairment Research
- Neuroscience, Education and Cognitive Function
- Children's Physical and Motor Development
- Mental Health Research Topics
- Time Series Analysis and Forecasting
- Birth, Development, and Health
- Visual and Cognitive Learning Processes
University of Liège
2016-2025
Walloon Excellence in Lifesciences and Biotechnology
2012-2024
Cyclotron (Netherlands)
2010-2022
University of Salzburg
2022
STMicroelectronics (United Kingdom)
2020-2021
University of Campania "Luigi Vanvitelli"
2009
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
1974-1981
Learning-dependent increases in sleep spindle density have been reported during nocturnal immediately after the learning session. Here, we investigated experience-dependent changes daytime EEG activity declarative of unrelated word pairs. At weekly intervals, 13 young male volunteers spent three 24 h sessions laboratory under carefully controlled homeostatic and circadian conditions. approximately midday, subjects performed either one two word-pair tasks or a matched nonlearning control...
Circadian rhythms and sleep deprivation Sleep deprivation, such as that experienced because of shift work, jet lag, disorders, aging, leads to deterioration many aspects health. Cognition deteriorates rapidly substantially when we stay awake through the night. To investigate time course brain responses during loss, Muto et al. scanned volunteers repeatedly an extended period wakefulness (see Perspective by Czeisler) in which circadian homeostatic drives differentially affected local regions....
Significance Evidence for seasonality in humans is limited. Mood probably stands as the aspect of human brain function most acknowledged being affected by season. Yet, present study provides compelling evidence previously unappreciated annual variations cerebral activity required to sustain ongoing cognitive processes healthy volunteers. The data further show that this rhythmicity cognitive-process-specific (i.e., phase rhythm changes between tasks), speaking a complex impact season on...
During non-rapid eye movement (NREM) sleep, a global decrease in synaptic strength associated with slow waves (SWs) would enhance signal-to-noise ratio of neural responses during subsequent wakefulness. To test this prediction, 32 human volunteers were trained to coarse orientation discrimination task, either the morning or evening. They retested after 8 h wakefulness respectively. Performance was enhanced only night absence any change abundance NREM SWs but proportion number "initiated"...
Over the past 40 years, actigraphy has been used to study rest-activity patterns in circadian rhythm and sleep research. Furthermore, considering its simplicity of use, there is a growing interest analysis large population-based samples, using actigraphy. Here, we introduce pyActigraphy , comprehensive toolbox for data visualization including multiple detection algorithms variables. This open-source python package implements methods read formats, quantify various properties rhythms,...
Sleep alteration is a hallmark of ageing and emerges as risk factor for Alzheimer’s disease (AD). While the fine-tuned coalescence sleep microstructure elements may influence age-related cognitive trajectories, its association with AD processes not fully established. Here, we investigated whether coupling spindles slow waves (SW) associated early amyloid-β (Aβ) brain burden, neuropathology, change over 2 years in 100 healthy individuals late-midlife (50–70 years; 68 women). We found that,...
The Attention Network Test (ANT) is deemed to assess the alerting, orientating and executive components of human attention. Capitalizing on opportunity investigate three facets attention in a single task, we used functional magnetic resonance imaging (fMRI) effect sleep deprivation (SD) brain responses associated with attentional elicited by ANT. Twelve healthy volunteers were scanned two conditions 1 week apart, after normal night (rested wakefulness, RW) or one total deprivation. Sleep was...
Sleep studies face new challenges in terms of data, objectives and metrics. This requires reappraising the adequacy existing analysis methods, including scoring methods. Visual automatic sleep healthy individuals were compared reliability (i.e., accuracy stability) to find a method capable giving access actual data variability without adding exogenous variability. A first dataset (DS1, four recordings) scored by six experts plus an autoscoring algorithm was used characterize inter-scoring...
Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing biomarkers. Given rapidly increasing number studies, DKI has potential to establish itself as valuable tool in brain diagnostics. However, become routine procedure, still needs be improved terms robustness, reliability, reproducibility. As it requires acquisitions at higher weightings, results are more affected by noise than imaging....
BACKGROUNDThe locus coeruleus (LC) is the primary source of norepinephrine in brain and regulates arousal sleep. Animal research shows that it plays important roles transition between sleep wakefulness, slow wave rapid eye movement (REMS). It unclear, however, whether activity LC predicts variability humans.METHODSWe used 7-Tesla functional MRI, electroencephalography (EEG), a questionnaire to test during wakefulness was associated with quality 33 healthy younger (~22 years old; 28 women, 5...
Daytime napping is frequently reported among the older population and has attracted increasing attention due to its association with multiple health conditions. Here, we tested whether in aged associated altered circadian regulation of sleep, sleepiness, vigilance performance.
The circadian system orchestrates sleep timing and structure is altered with increasing age. Sleep propensity, particularly REM under strong control has been suggested to play an important role in brain plasticity. In this exploratory study, we assessed whether surface-based morphometry indices are associated regulation link changes Twenty-nine healthy older (55-82 years; 16 men) 28 young participants (20-32 13 underwent both structural magnetic resonance imaging a 40-h multiple nap protocol...
Abstract Objective Parkinson’s disease (PD) is one of the rare diseases for which sleep alteration a true marker outcome. Yet, how association between and PD emerges over healthy lifetime not established. We examined polygenic risk score (PRS) variability in electrophysiology Rapid Eye Movement (REM) 345 younger (18-31y) 85 older (50-69y) individuals. Methods In this prospective cross-sectional study, in-lab EEG recordings were recorded to extract REM metrics. PRS was computed using SBayesR...
Memories are consolidated during sleep by two apparently antagonistic processes: (1) reinforcement of memory-specific cortical interactions and (2) homeostatic reduction in synaptic efficiency. Using fMRI, we assessed whether episodic memories processed either or both mechanisms, comparing recollection before after sleep. We probed LTP influences these processes contrasting groups individuals prospectively recruited based on BDNF rs6265 (Val66Met) polymorphism. Between immediate retrieval...
Brain-derived neurotrophic factor (BDNF) modulates the pruning of synaptically silent axonal arbors. The Met allele BDNF gene is associated with a reduction in neurotrophin's activity-dependent release. We used diffusion-weighted imaging to construct structural brain networks for 36 healthy subjects known genotypes. Through permutation testing we discovered clear differences connection strength between carrying and those homozygotic Val allele. trained Gaussian process classifier capable...
We investigated whether cognitive fitness in late midlife is associated with physiological and psychological factors linked to increased risk of age-related decline.Eighty-one healthy middle-aged participants (mean age: 59.4 y; range: 50-69 y) were included.Cognitive consisted a composite score known be sensitive early subtle change.Lifestyle (referenced below as reserve factors; CRF) affective state determined through questionnaires, sleep-wake quality was also assessed actimetry.Allostatic...
Abstract Study Objectives Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease (AD). Our goal was to assess whether genome-wide polygenic scores (PRS) AD associate with sleep phenotypes in young adults, decades before typical symptom onset. Methods We computed whole-genome PRS extensively phenotyped under different conditions, including baseline sleep, recovery following deprivation, extended opportunity, a carefully selected homogenous sample...
BACKGROUNDTight relationships between sleep quality, cognition, and amyloid-β (Aβ) accumulation, a hallmark of Alzheimer's disease (AD) neuropathology, have been shown. Sleep arousals become more prevalent with aging are considered to reflect poorer quality. However, heterogeneity in has suggested while their associations Aβ cognition not established.METHODSWe recorded undisturbed night-time EEG 101 healthy individuals aged 50-70 years, devoid cognitive disorders. We classified spontaneous...
Abstract Age-related cognitive decline arises from alterations in brain structure as well sleep-wake regulation. Here, we investigated whether preserved wake-dependent regulation of cortical function could represent a positive factor for fitness aging. We quantified excitability dynamics during prolonged wakefulness sensitive marker age-related alteration 60 healthy older individuals (50–69 y; 42 women). Brain structural integrity was assessed with amyloid-beta- and tau-PET, MRI....