A5070262261- Sleep and related disorders
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Maternal Mental Health During Pregnancy and Postpartum
- Coffee research and impacts
- Impact of Light on Environment and Health
- Sleep and Work-Related Fatigue
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Infant Development and Preterm Care
- Attention Deficit Hyperactivity Disorder
- Psychological and Temporal Perspectives Research
- Schizophrenia research and treatment
- Breastfeeding Practices and Influences
- Gestational Diabetes Research and Management
- Bipolar Disorder and Treatment
- Noise Effects and Management
- Ophthalmology and Visual Impairment Studies
- Eating Disorders and Behaviors
- Neonatal and fetal brain pathology
- Cognitive Abilities and Testing
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
Circadian (United States)
2024
University of Basel
2014-2024
Brigham and Women's Hospital
2023-2024
Harvard University
2024
Laboratory for Biomedical Neurosciences
2022-2024
Università della Svizzera italiana
2024
Ospedale regionale di Lugano
2018-2024
Universitäre Psychiatrische Kliniken Basel
2022-2023
Swiss Epilepsy Center
2016-2019
Humboldt-Universität zu Berlin
2018
Humans live in a 24-hour environment, which light and darkness follow diurnal pattern. Our circadian pacemaker, the suprachiasmatic nuclei (SCN) hypothalamus, is entrained to solar day via pathway from retina synchronises our internal biological rhythms. Rhythmic variations ambient illumination impact behaviours such as rest during sleep activity wakefulness well their underlying processes. Rather recently, availability of artificial has substantially changed especially evening night hours....
PurposeAdolescents prefer sleep and wake times that are considerably delayed compared with younger children or adults. Concomitantly, multimedia use in the evening is prevalent among teenagers involves light exposure, particularly blue-wavelength range to which biological clock its associated arousal promotion system most sensitive. We investigated whether of blue light–blocking glasses (BB) during evening, while sitting front a light-emitting diode (LED) computer screen, favors initiating...
LED *Shared senior authors. light sources have a discontinuous spectrum with prominent ‘blue’ peak between 450 and 470 nm that influences non-image forming responses in humans. We tested an lighting solution mimicking daylight on visual comfort, circadian physiology, daytime alertness, mood, cognitive performance sleep. Fifteen young males twice spent 49 hours the laboratory under conventional-LED daylight-LED condition balanced cross over design flanked by baseline post-light exposure...
BackgroundThere is no consensus on reporting light characteristics in studies investigating non-visual responses to light. This project aimed develop a checklist for laboratory-based investigations the impact of physiology.MethodsA four-step modified Delphi process (three questionnaire-based feedback rounds and one face-to-face group discussion) involving international experts was conducted reach items be included checklist. Following process, resulting tested pilot phase with independent...
We tested the effect of different lights as a countermeasure against sleep-loss decrements in alertness, melatonin and cortisol profile, skin temperature wrist motor activity healthy young older volunteers under extendend wakefulness. 26 [mean (SE): 25.0 (0.6) y)] 12 participants [(mean 63.6 (1.3) underwent 40-h sustained wakefulness during 3 balanced crossover segments, once dim light (DL: 8 lx), either white (WL: 250 lx, 2,800 K) or blue-enriched (BL: 9,000 exposure. Subjective sleepiness,...
Perinatal depression (PND) is a severe complication of pregnancy, affecting both mothers and newborns. Bright light therapy (BLT) has only been tested in few studies for treating either antenatal or postnatal depression. We conducted pilot trial to investigate the efficacy safety BLT PND occurring at any time across perinatal period.
Humans live in a 24-hour environment, which light and darkness follow diurnal pattern. Our circadian pacemaker, the suprachiasmatic nuclei (SCN) hypothalamus, is entrained to solar day via pathway from retina synchronises our internal biological rhythms. Rhythmic variations ambient illumination impact behaviours such as rest during sleep activity wakefulness well their underlying processes. Rather recently, availability of artificial has substantially changed especially evening night hours....
Nighttime transportation noise elicits awakenings, sleep-stage changes, and electroencephalographic (EEG) arousals. Here, we investigated the potential sleep-protective role of sleep spindles on noise-induced alterations. Twenty-six young (19–33 years, 12 women) 18 older (52–70 9 healthy volunteers underwent a repeated measures polysomnographic 6-day laboratory study. Participants spent one noise-free baseline night, followed by four noise-exposure nights (road traffic or railway noise;...
Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent disturbs slow-wave (SWS) delays timing in teenagers. Following 6-day ambulatory phase of abstinence fixed sleep-wake cycles, 18 male teenagers (14-17 years old) ingested 80 mg vs. placebo...
Caffeine elicits widespread effects in the central nervous system and is most frequently consumed psychostimulant worldwide. First evidence indicates that, during daily intake, elimination of caffeine may slow down, primary metabolite, paraxanthine, accumulate. The neural impact such adaptions virtually unexplored. In this report, we leveraged data a laboratory study with N = 20 participants three within-subject conditions: (150 mg × 3/day 10 days), placebo mannitol acute deprivation...
Perinatal depression (PND) is a common complication of pregnancy associated with serious health consequences for both mothers and their babies. Identifying risk factors PND key to early detect women at increased developing this condition. We applied machine learning (ML) approach data from multicenter cohort study on sleep mood changes during the perinatal period ("Life-ON") derive models prediction in cross-validation setting. A wide range sociodemographic variables, blood-based biomarkers,...
The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and circadian C, determines timing of sleep in an approximately 24h rhythm accordance to external light-dark (LD) cycle. While both individual processes are fairly well characterized, exact nature their interaction remains unclear. generated subthalamic nucleus (SCN, "master clock") anterior hypothalamus, through cell-autonomous feedback loops DNA...
Perinatal depression (PND) has an overall estimated prevalence of roughly 12 %. Untreated PND significant negative consequences not only on the health mothers, but also physical, emotional and cognitive development their children. No certain risk factors are known to predict no completely safe drug treatments available during pregnancy breastfeeding. Sleep strongly related each other because a solid reciprocal causal relationship. Bright light therapy (BLT) is well-tested treatment,...
Abstract Study Objectives Sleep-related slow-wave activity (SWA) has been recognized as a marker of synaptic plasticity. In children affected by attention deficit hyperactivity disorder (ADHD), SWA is mainly located in the central rather than frontal regions, reflecting maturational delay. A detailed subjective and objective sleep investigation, including full night video-polysomnography (PSG-HD-EEG), was performed on 30 consecutive drug naïve outpatients with diagnosis ADHD. They received...