A5091679650- Sleep and related disorders
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Coffee research and impacts
- Eating Disorders and Behaviors
- Functional Brain Connectivity Studies
- Impact of Light on Environment and Health
- Memory and Neural Mechanisms
- Obesity, Physical Activity, Diet
- Spaceflight effects on biology
- Mind wandering and attention
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Cognitive Abilities and Testing
- Dementia and Cognitive Impairment Research
- Heart Rate Variability and Autonomic Control
- Human-Automation Interaction and Safety
- Health, Environment, Cognitive Aging
- Cancer-related cognitive impairment studies
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Ergonomics and Musculoskeletal Disorders
- Vagus Nerve Stimulation Research
University of Basel
2016-2025
Universitäre Psychiatrische Kliniken Basel
2022-2024
Psychiatry Baselland
2022
University of Liège
2014
Universität Trier
2009
Light exposure elicits numerous effects on human physiology and behavior, such as better cognitive performance mood. Here we investigated the role of morning light a countermeasure for impaired mood under sleep restriction (SR). Seventeen participants took part 48h laboratory protocol, during which three different settings (separated by 2 wks) were administered each after two 6-h nights: blue monochromatic LED (light-emitting diode) condition (BL; 100 lux at 470 nm 20 min) starting h...
Light exposure, particularly at the short-wavelength range, triggers several nonvisual responses in humans. However, extent to which melatonin-suppressing and alerting effect of light differs among individuals remains unknown.Here we investigated whether blue-enriched polychromatic impacts differentially on melatonin subjective objective alertness healthy participants genotyped for PERIOD3 (PER3) variable-number, tandem-repeat polymorphism.Eighteen young men homozygous PER3 polymorphism...
We tested the effect of different lights as a countermeasure against sleep-loss decrements in alertness, melatonin and cortisol profile, skin temperature wrist motor activity healthy young older volunteers under extendend wakefulness. 26 [mean (SE): 25.0 (0.6) y)] 12 participants [(mean 63.6 (1.3) underwent 40-h sustained wakefulness during 3 balanced crossover segments, once dim light (DL: 8 lx), either white (WL: 250 lx, 2,800 K) or blue-enriched (BL: 9,000 exposure. Subjective sleepiness,...
Abstract Acute caffeine intake has been found to increase working memory (WM)-related brain activity in healthy adults without improving behavioral performances. The impact of daily intake—a ritual shared by 80% the population worldwide—and its discontinuation on and neural correlates remained unknown. In this double-blind, randomized, crossover study, we examined functions 20 young non-smokers (age: 26.4 ± 4.0 years; body mass index: 22.7 1.4 kg/m 2 ; habitual intake: 474.1 107.5 mg/day) a...
Morning-type individuals experience more difficulties to maintain optimal attentional performance throughout a normal waking day than evening types. However, time-of-day modulations may differ across cognitive domains. Using functional magnetic resonance imaging (fMRI), we investigated how chronotype and time of interact with working memory at different levels load/complexity in N-back paradigm (N0-, N2-, N3-back levels). Extreme morning- evening-type underwent two fMRI sessions during...
Abstract Acute caffeine intake can delay sleep initiation and reduce intensity, particularly when consumed in the evening. However, it is not clear whether these disturbances disappear continuously during daytime, which common for most coffee drinkers. To address this question, we investigated of twenty male young habitual consumers a double-blind, randomized, crossover study including three 10-day conditions: (3 × 150 mg daily), withdrawal 8 days, then switch to placebo), placebo daily)....
Fixed sleep schedules with an 8 h time in bed (TIB) are used to ensure participants well-rested before laboratory studies. However, such may lead cumulative excess wakefulness young individuals. Effects on older individuals unknown. We combine modelling and experimental data quantify the effects of debt propensity healthy younger participants. A model arousal dynamics was fitted from 22 (20–31 y.o.) 26 (61–82 (25 male) undertaking 10 short sleep–wake cycles during a 40 napping protocol,...
We examined whether ambient lighting conditions during extended wakefulness modulate the homeostatic response to sleep loss as indexed by. slow wave (SWS) and electroencephalographic (EEG) slow-wave activity (SWA) in healthy young older volunteers. Thirty-eight participants underwent 40 hours of [i.e., deprivation (SD)] once under dim light (DL: 8 lux, 2800 K), either white (WL: 250 K) or blue-enriched (BL: 9000 exposure. Subjective sleepiness was assessed hourly polysomnography quantified...
Abstract Caffeine is commonly used to combat high sleep pressure on a daily basis. However, interference with sleep–wake regulation could disturb neural homeostasis and insufficient lead alterations in human gray matter. Hence, this double-blind, randomized, cross-over study, we examined the impact of 10-day caffeine (3 × 150 mg/day) matter volumes (GMVs) cerebral blood flow (CBF) by fMRI MP-RAGE arterial spin-labeling sequences 20 habitual consumers, compared placebo mg/day). Sleep was...
Acute caffeine intake can attenuate homeostatic sleep pressure and worsen quality. Caffeine intake-particularly in high doses close to bedtime-may also affect circadian-regulated rapid eye movement (REM) promotion, an important determinant of subjective However, it is not known whether such changes persist under chronic consumption during daytime. Twenty male consumers (26.4 ± 4 years old, habitual 478.1 102.8 mg/day) participated a double-blind crossover study. Each volunteer completed (3 ×...
Sleep varies between individuals in response to sleep-wake history and various environmental factors, including light noise. Here we report on the intranight variation of ultradian nonrapid eye movement-rapid movement (NREM-REM) sleep cycle 369 participants who have contributed different laboratory studies from 1994 2020 at Centre for Chronobiology, Basel, Switzerland. We observed a large interindividual variability duration, NREM REM episodes healthy were given an 8-hour opportunity...
The circadian system orchestrates sleep timing and structure is altered with increasing age. Sleep propensity, particularly REM under strong control has been suggested to play an important role in brain plasticity. In this exploratory study, we assessed whether surface-based morphometry indices are associated regulation link changes Twenty-nine healthy older (55-82 years; 16 men) 28 young participants (20-32 13 underwent both structural magnetic resonance imaging a 40-h multiple nap protocol...
Sleepiness and cognitive function vary over the 24-h day due to circadian sleep-wake-dependent mechanisms. However, underlying cerebral hallmarks associated with these variations remain be fully established. Using functional magnetic resonance imaging (fMRI), we investigated brain responses homeostatic sleep-wake-driven dynamics of subjective sleepiness throughout night. Healthy volunteers regularly performed a psychomotor vigilance task (PVT) in MR-scanner during 40-h sleep deprivation...
Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent disturbs slow-wave (SWS) delays timing in teenagers. Following 6-day ambulatory phase of abstinence fixed sleep-wake cycles, 18 male teenagers (14-17 years old) ingested 80 mg vs. placebo...
Caffeine elicits widespread effects in the central nervous system and is most frequently consumed psychostimulant worldwide. First evidence indicates that, during daily intake, elimination of caffeine may slow down, primary metabolite, paraxanthine, accumulate. The neural impact such adaptions virtually unexplored. In this report, we leveraged data a laboratory study with N = 20 participants three within-subject conditions: (150 mg × 3/day 10 days), placebo mannitol acute deprivation...
Sleep loss affects human behavior in a nonuniform manner, depending on the cognitive domain and also circadian phase. Besides, evidence exists about stable interindividual variations sleep loss–related performance impairments. Despite this evidence, only few studies have considered both phase neurobehavioral when investigating trait-like vulnerability to manipulation. By applying randomized, crossover design with 2 pressure conditions (40 h deprivation vs. 40 multiple naps), we investigated...
Under sleep loss, vigilance is reduced and attentional failures emerge progressively. It becomes difficult to maintain stable performance over time, leading growing variability (i.e., state instability) in an individual among subjects. Task duration plays a major role the maintenance of levels, such that longer task, more likely instability will be observed. Vulnerability sleep-loss-dependent decrements highly also modulated by polymorphism human clock gene PERIOD3 (PER3). By combining two...