A5003649839- Coffee research and impacts
- Sleep and related disorders
- Antibiotics Pharmacokinetics and Efficacy
- Sleep and Wakefulness Research
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Eating Disorders and Behaviors
- Antimicrobial Resistance in Staphylococcus
- Circadian rhythm and melatonin
- Malaria Research and Control
- Bacterial Identification and Susceptibility Testing
- Drug Transport and Resistance Mechanisms
- Tryptophan and brain disorders
- Pharmaceutical studies and practices
- Radiation Dose and Imaging
- Drug-Induced Hepatotoxicity and Protection
- Tea Polyphenols and Effects
- Antibiotic Use and Resistance
University Hospital of Basel
2019-2022
University of Basel
2020-2021
University Hospital of Zurich
2019
University Hospital of Bern
2019
University of Bern
2019
University Children's Hospital Zurich
2019
Abstract Acute caffeine intake can delay sleep initiation and reduce intensity, particularly when consumed in the evening. However, it is not clear whether these disturbances disappear continuously during daytime, which common for most coffee drinkers. To address this question, we investigated of twenty male young habitual consumers a double-blind, randomized, crossover study including three 10-day conditions: (3 × 150 mg daily), withdrawal 8 days, then switch to placebo), placebo daily)....
Acute caffeine intake can attenuate homeostatic sleep pressure and worsen quality. Caffeine intake-particularly in high doses close to bedtime-may also affect circadian-regulated rapid eye movement (REM) promotion, an important determinant of subjective However, it is not known whether such changes persist under chronic consumption during daytime. Twenty male consumers (26.4 ± 4 years old, habitual 478.1 102.8 mg/day) participated a double-blind crossover study. Each volunteer completed (3 ×...
TDM of antibiotics can bring benefits to patients and healthcare systems by providing better treatment saving resources. We aimed develop a multi-analyte method for several diverse using LC-MS/MS. Sample preparation consisted protein precipitation with methanol, dilution online extraction Turboflow Cyclone column. Separation was performed on Synergi 4 µm Max RP column deuterated forms three were used as internal standards. present LC-MS/MS the quantitative determination nine antibiotics,...
Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent disturbs slow-wave (SWS) delays timing in teenagers. Following 6-day ambulatory phase of abstinence fixed sleep-wake cycles, 18 male teenagers (14-17 years old) ingested 80 mg vs. placebo...
Caffeine elicits widespread effects in the central nervous system and is most frequently consumed psychostimulant worldwide. First evidence indicates that, during daily intake, elimination of caffeine may slow down, primary metabolite, paraxanthine, accumulate. The neural impact such adaptions virtually unexplored. In this report, we leveraged data a laboratory study with N = 20 participants three within-subject conditions: (150 mg × 3/day 10 days), placebo mannitol acute deprivation...
MSSA bloodstream infections (BSIs) are associated with considerable mortality. Data regarding therapeutic drug monitoring (TDM) and pharmacological target attainment of the β-lactam flucloxacillin scarce.We determined achievement pharmacokinetic/pharmacodynamic targets its association clinical outcome potential toxicity in a prospective cohort 50 patients MSSA-BSI. Strain-specific MICs unbound plasma concentrations (at five different timepoints) were by broth microdilution HPLC-MS,...
Background: Artemisia annua is a Chinese medicinal herb. Artemisinin-derivatives are recommended as part of combination treatment for uncomplicated malaria. Herbal and dietary supplements (HDS) increasingly used worldwide HDS-induced liver injury becoming growing concern. Case Report: We present the first case severe acute cholestatic hepatitis due to intake tea chemoprophylaxis malaria in patient returning from Ethiopia. The patients presented with jaundice, elevated transaminases...
Amoxicillin-clavulanic acid (AMC) belongs to the WHO Essential Medicines List for children, but optimal antimicrobial effectiveness, reconstituted dry powder suspensions need be stored in a refrigerated environment. Many patients low- and middle-income countries who are sold AMC would expected not keep specified storage conditions. We aimed assess stability of both ingredients liquid formulations dispersible tablets, combined with nationally representative data on access appropriate storage....
Abstract To enhance wakefulness, daily consumption of caffeine in the morning and afternoon is highly common. However, it unknown whether such a regular intake pattern affects timing quality as regulated by an interplay circadian sleep-homeostatic mechanisms. Thus, we investigated effects its withdrawal on rhythms wake-promotion 20 male young habitual consumers. We applied double-blind, within-subject design with (150 mg, 3 x daily), placebo, condition each lasting ten days. Starting day...
Abstract Acute caffeine intake can delay sleep initiation and reduce intensity, particularly when consumed in the evening. However, it is not clear whether these disturbances disappear continuously during daytime, which common for most coffee drinkers. To address this question, we investigated of twenty male young habitual consumers a double-blind, randomized, crossover study including three 10-day conditions: (3 x 150 mg daily), withdrawal eight days, then switch to placebo), placebo...
Abstract Background Adolescents frequently consume caffeine with unknown consequences on sleep and circadian rhythms. In adults, the evidence indicates that acutely reduces homeostatic pressure delays timing system. Objective Here, we investigated acute effects of intake developing sleep-wake regulatory system teenagers. Design a double-blind randomized crossover laboratory study, 18 teenagers (16.1 ± 1 years old, pubertal development scale [PDS]: 2.76 0.35) ingested 80 mg (vs placebo) four...
Abstract Acute caffeine intake can attenuate homeostatic sleep pressure and worsen quality. Besides, – particularly in high doses close to bedtime may also affect circadian-regulated REM promotion, an important determinant of subjective However, it is not known whether such changes persist under chronic consumption during daytime. Twenty male consumers (26.4 ± 4 years old, habitual 478.1 102.8 mg/day) participated a double-blind crossover study. Each volunteer completed (3 × 150 mg daily),...
Abstract Caffeine elicits widespread effects in the central nervous system and is most frequently consumed psychostimulant worldwide. First evidence indicates that, during daily intake, elimination of caffeine may slow down primary metabolite, paraxanthine, accumulate. The neural impact such adaptions virtually unexplored. In this report, we leveraged data a laboratory study with N= 20 participants three within-subject conditions: (150 mg x 3/day 10 days), placebo mannitol withdrawal...
Background Amoxicillin-clavulanate (AMC) is among the most frequently used antibiotic for paediatric infections globally. AMC child-appropriate formulations are largely limited to dry powder suspensions, which have be stored refrigerated once reconstituted due stability limitations of clavulanate. Methods Oral Amoxicillin (AMX) and were identified from IQVIA-MIDAS wholesale data, 2015 consumption in courses/1000 child-years was estimated Bangladesh, India, Indonesia, Pakistan, Philippines...
An analytical method for the quantification of four beta-lactam antibiotics (amoxicillin, flucloxacillin, piperacillin, and benzylpenicillin), two beta-lactamase inhibitors (clavulanic acid tazobactam) as well macrolide antibiotic clindamycin in different matrices is presented.The uses 2D high performance liquid chromatography followed by tandem mass spectrometry.Sample preparation all was protein precipitation dilution.As internal standards, deuterated forms beta-lactams were used.All...