A5018649360- Muscle metabolism and nutrition
- Metabolism and Genetic Disorders
- Muscle Physiology and Disorders
- Diet and metabolism studies
- Connexins and lens biology
- Genetic Neurodegenerative Diseases
- Heat shock proteins research
- Biochemical and Molecular Research
- Developmental Biology and Gene Regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Genetics and Physical Performance
- Radiation Dose and Imaging
- Yersinia bacterium, plague, ectoparasites research
- Marine animal studies overview
University of Lausanne
2020-2024
University Hospital of Lausanne
2020-2021
University of Bern
2019-2021
University Hospital of Basel
2019
University Hospital of Zurich
2019
University Hospital of Bern
2019
University Children's Hospital Zurich
2019
Abstract Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high demand such muscle or brain. taken from the diet endogenously synthetized by enzymes AGAT and GAMT, specifically up transporter SLC6A8. Deficit endogenous synthesis transport leads Cerebral Deficiency Syndromes (CCDS). CCDS are characterized brain creatine deficiency, intellectual disability severe speech delay, behavioral troubles attention deficits and/or autistic...
Creatine deficiency syndromes (CDS), caused by mutations in
Abstract Creatine (Cr) is a nitrogenous organic acid and plays roles such as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, compound with anabolic ergogenic properties in muscle. Cr taken from the diet or endogenously synthetized by enzymes arginine:glycine amidinotransferase guanidinoacetate methyltransferase, specifically up transporter SLC6A8. Loss‐of‐function mutations genes encoding for cause creatine deficiency syndromes (CDS). CDS are...
Sensorineural hearing loss is prevalent within society affecting the quality of life 460 million worldwide. In majority cases, this due to insult or degeneration mechanosensory hair cells in cochlea. adult mammals, cell irreversible as sensory are not replaced spontaneously. Genetic inhibition Notch signaling had been shown induce formation by transdifferentiation supporting young postnatal rodents and provided an impetus for targeting pathway with small molecule inhibitors restoration....
Sensorineural hearing loss is the most common long-term deficit after pneumococcal meningitis (PM), occurring in up to 30% of surviving patients. The infection and following overshooting inflammatory host response damage vulnerable sensory cells inner ear, resulting hair spiral ganglion neurons, ultimately leading elevated thresholds. Here, we tested oto-protective properties small heat shock protein alpha B-crystallin (HspB5) with previously reported anti-inflammatory, anti-apoptotic...
An analytical method for the quantification of four beta-lactam antibiotics (amoxicillin, flucloxacillin, piperacillin, and benzylpenicillin), two beta-lactamase inhibitors (clavulanic acid tazobactam) as well macrolide antibiotic clindamycin in different matrices is presented.The uses 2D high performance liquid chromatography followed by tandem mass spectrometry.Sample preparation all was protein precipitation dilution.As internal standards, deuterated forms beta-lactams were used.All...
ABSTRACT Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high demand such muscle or brain. taken from the diet endogenously synthetized by enzymes AGAT and GAMT, specifically up transporter SLC6A8. Deficit endogenous synthesis transport leads Cerebral Deficiency Syndromes (CCDS). CCDS are characterized brain creatine deficiency, intellectual disability severe speech delay, behavioral troubles attention deficits and/or autistic...
ABSTRACT Creatine (Cr) is a nitrogenous organic acid and plays roles as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, compound with anabolic ergogenic properties in muscle. Cr taken from the diet or endogenously synthetized by enzymes AGAT GAMT, specifically up transporter SLC6A8. Loss-of-function mutations genes encoding for cause Cerebral Deficiency Syndromes (CCDS). CCDS are characterized brain deficiency, intellectual disability severe speech...