A5079985500- Circadian rhythm and melatonin
- Impact of Light on Environment and Health
- Virtual Reality Applications and Impacts
- Color perception and design
- Sleep and related disorders
- Augmented Reality Applications
- Spaceflight effects on biology
- Advanced Optical Imaging Technologies
- Interactive and Immersive Displays
- Dietary Effects on Health
- Human-Automation Interaction and Safety
- Ergonomics and Musculoskeletal Disorders
- Olfactory and Sensory Function Studies
- Building Energy and Comfort Optimization
- Sleep and Wakefulness Research
- Climate Change and Health Impacts
- Spatial Cognition and Navigation
- Health, Environment, Cognitive Aging
- Sleep and Work-Related Fatigue
- Mental Health Research Topics
- Green IT and Sustainability
- Visual perception and processing mechanisms
- Behavioral Health and Interventions
- Heart Rate Variability and Autonomic Control
- Urban Green Space and Health
Lucerne University of Applied Sciences and Arts
2023-2025
University of Basel
2005-2024
University of Lucerne
2024
Universitäre Psychiatrische Kliniken Basel
2019-2022
Fraunhofer Institute for Industrial Engineering
2003-2016
Many people spend an increasing amount of time in front computer screens equipped with light-emitting diodes (LED) a short wavelength (blue range). Thus we investigated the repercussions on melatonin (a marker circadian clock), alertness, and cognitive performance levels 13 young male volunteers under controlled laboratory conditions balanced crossover design. A 5-h evening exposure to white LED-backlit screen more than twice as much 464 nm light emission {irradiance 0,241 Watt/(steradian ×...
Light is necessary for vision; it enables us to sense and perceive our surroundings in many direct indirect ways, via eye skin, affects physiological psychological health. The use of light built environments has comfort, behavioural, economic environmental consequences. Daylight particular benefits including excellent visual performance, permitting good eyesight, effective entrainment the circadian system as well a number acute non-image forming effects important role vitamin D production....
Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) the same city of Tyumen, Russia. Groups with different COVID-19 status (present, COVID-19(+),
Daylight stems solely from direct, scattered and reflected sunlight, undergoes dynamic changes in irradiance spectral power composition due to latitude, time of day, year the nature physical environment (reflections, buildings vegetation). Humans their ancestors evolved under these natural day/night cycles over millions years. Electric light, a relatively recent invention, interacts competes with light–dark cycle impact human biology. What are consequences living industrialised urban areas...
Exposure to light has short- and long-term impacts on non-visual responses in humans. While many aspects related sensitivity have been characterised (such as the action spectrum for melatonin suppression), much remains be elucidated. Here, we provide a set of minimum reporting guidelines stimulus conditions involving an intervention chronobiology, sleep research environmental psychology experiments. Corresponding current state-of-the-art knowledge (June 2019), these are (i) measure report...
LED *Shared senior authors. light sources have a discontinuous spectrum with prominent ‘blue’ peak between 450 and 470 nm that influences non-image forming responses in humans. We tested an lighting solution mimicking daylight on visual comfort, circadian physiology, daytime alertness, mood, cognitive performance sleep. Fifteen young males twice spent 49 hours the laboratory under conventional-LED daylight-LED condition balanced cross over design flanked by baseline post-light exposure...
Abstract Light‐induced melatonin suppression data from 29 peer‐reviewed publications was analysed by means of a machine‐learning approach to establish which light exposure characteristics (ie photopic illuminance, five α‐opic equivalent daylight illuminances [EDIs], duration and timing the exposure, dichotomous variables pharmacological pupil dilation narrowband source) are main determinants suppression. Melatonin in set dominated four characteristics: (1) melanopic EDI, (2) duration, (3)...
Evening light-emitting visual displays may disrupt sleep, suppress melatonin and increase alertness. Here, we control melanopic irradiance independent of display luminance colour, in 72 healthy males 4 h before habitual bedtime expose each them to one four levels (i.e., dim light, smartphone, tablet or computer screen illuminance) at a low high setting. Low light shortens the time fall asleep, attenuates evening suppression, reduces morning melatonin, advances onset decreases alertness...
BackgroundThere is no consensus on reporting light characteristics in studies investigating non-visual responses to light. This project aimed develop a checklist for laboratory-based investigations the impact of physiology.MethodsA four-step modified Delphi process (three questionnaire-based feedback rounds and one face-to-face group discussion) involving international experts was conducted reach items be included checklist. Following process, resulting tested pilot phase with independent...
This study explores the relationship between light features of Arctic spring equinox and circadian rhythms, sleep metabolic health. Residents (N = 62) provided week-long actigraphy measures, including exposure, which were related to body mass index (BMI), leptin cortisol. Lower wrist temperature (wT) higher evening blue exposure (BLE), expressed as a novel index, nocturnal excess (NEIbl), most sensitive measures associated with BMI. A BMI was linked BLE within distinct time windows. These...
We examined whether dynamically changing light across a scheduled 16-h waking day influences sleepiness, cognitive performance, visual comfort, melatonin secretion, and sleep under controlled laboratory conditions in healthy men. Fourteen participants underwent 49-h protocol repeated-measures study design. They spent the first 5 hours evening standard lighting, followed by an 8-h nocturnal episode at habitual bedtimes. Thereafter, volunteers either woke up to static or dynamic that changed...
A weekly actigraphy was conducted within a single month in 122 young adults, who were categorized into two groups: COVID(-): individuals without SARS-CoV-2 infection, n = 43; COVID(+), 79: with confirmed infection. Physical activity, wrist temperature, sleep parameters, and light exposure compared. Higher daytime ambient (LE), blue (BLE) ultraviolet B (UVBE) COVID(-) group. In multivariate model, incorporating BLE amplitude, M10 of physical age, sex, amplitude remained the only significant...
Light environment in the Arctic differs widely with seasons. Studies of relationships between objectively measured circadian phase and amplitude light exposure melatonin community-dwelling residents are lacking. This investigation combines cross-sectional (n = 24-62) longitudinal 13-27) data from week-long actigraphy (with sensor), 24-h salivary profiles, proxies metabolic health. Data were collected within same week bracketing spring equinox (SE), winter/summer solstices (WS/SS). Drastic...
The pupil modulates the amount of light that reaches retina. Not only luminance but also spectral distribution defines size. Previous research has identified steady-state size and melatonin attenuation to be predominantly driven by melanopsin, which is expressed a unique subgroup intrinsically photosensitive retinal ganglion cells (ipRGCs) are sensitive short-wavelength (~480 nm). Here, we aimed selectively target melanopsin system during evening, while measuring concentrations under...
Nuclear receptor subfamily 1 group D member (NR1D1 or REV-ERBα) is a crucial element of the circadian clock's transcriptional and translational feedback loop. Understanding its expression in humans critical for elucidating role rhythms metabolic processes, finding potential links to various pathologies. In longitudinal survey we examined REV-ERBα at 08:00 using real-time polymerase chain reaction (qRT-PCR) blood mononuclear cells from Arctic native non-native residents during...
Nuclear receptor subfamily 1 group D member (NR1D1 or REV-ERBα) is a crucial element of the circadian clock’s transcriptional and translational feedback loop. Understanding its expression in humans critical for elucidating role rhythms metabolic processes, finding potential links to various pathologies. In longitudinal survey, we examined REV-ERBα at 08:00 using real-time polymerase chain reaction (qRT-PCR) blood mononuclear cells from Arctic native non-native residents during equinoxes...
It is well known that variations in light exposure during the day affect sensitivity evening. More daylight reduces sensitivity, and less increases it. On average days, we spend time outdoors winter receive far than summer. Therefore, it could be relevant when collecting research data on non-image forming (NIF) effects of circadian rhythms sleep. In fact, studies conducted only may result more pronounced NIF Here, systematically collected information extent to which evening include season...
Sleep varies between individuals in response to sleep-wake history and various environmental factors, including light noise. Here we report on the intranight variation of ultradian nonrapid eye movement-rapid movement (NREM-REM) sleep cycle 369 participants who have contributed different laboratory studies from 1994 2020 at Centre for Chronobiology, Basel, Switzerland. We observed a large interindividual variability duration, NREM REM episodes healthy were given an 8-hour opportunity...
Comfort is an important factor in the acceptance of transport systems. In 2010 and 2011, European Commission (EC) put forward its vision for air travel year 2050 which envisaged use in-flight virtual reality. This paper addressed EC by investigating effect environments on comfort. Research has shown that can provide entertaining experiences be effective distracters from painful experiences.To determine extent to a environment could distract people sources discomfort.Experiments involved...
Abstract Light profoundly impacts many aspects of human physiology and behaviour, including the synchronization circadian clock, production melatonin, cognition. These effects light, termed non-visual have been primarily investigated in laboratory settings, where light intensity, spectrum timing can be carefully controlled to draw associations with physiological outcomes interest. Recently, increasing availability wearable loggers has opened possibility studying personal exposure free-living...