A5028241466- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Dermatology and Skin Diseases
- Osteoarthritis Treatment and Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Otitis Media and Relapsing Polychondritis
- Musculoskeletal synovial abnormalities and treatments
- Atherosclerosis and Cardiovascular Diseases
- Orthopedic Surgery and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Nail Diseases and Treatments
- Infectious Diseases and Tuberculosis
- Systemic Sclerosis and Related Diseases
- MRI in cancer diagnosis
- Myofascial pain diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- Diverticular Disease and Complications
Ottawa Hospital Research Institute
2017-2025
Ottawa Hospital
2017-2025
University of Ottawa
2016-2025
Izmir Institute of Technology
2024
AbbVie (United States)
2024
Eli Lilly (United States)
2024
Pfizer (United States)
2024
University of Wisconsin–Madison
2024
Neurological Surgery
2024
Center for Rheumatology
2009-2023
The objective of this study was to develop EULAR/ACR classification criteria for polymyalgia rheumatica (PMR). Candidate were evaluated in a 6-month prospective cohort 125 patients with new onset PMR and 169 non-PMR comparison subjects conditions mimicking PMR. A scoring algorithm developed based on morning stiffness >45 minutes (2 points), hip pain/limited range motion (1 point), absence RF and/or ACPA peripheral joint pain point). score ≥4 had 68% sensitivity 78% specificity discriminating...
Abstract The objective of this study was to develop European League Against Rheumatism/American College Rheumatology classification criteria for polymyalgia rheumatica (PMR). Candidate were evaluated in a 6‐month prospective cohort 125 patients with new‐onset PMR and 169 non‐PMR comparison subjects conditions mimicking PMR. A scoring algorithm developed based on morning stiffness >45 minutes (2 points), hip pain/limited range motion (1 point), absence rheumatoid factor and/or...
To standardize ultrasound (US) in enthesitis.An initial Delphi exercise was undertaken to define US-detected enthesitis and its core components. These definitions were subsequently tested on static images taken from spondyloarthritis patients order evaluate their reliability.Excellent agreement (>80%) obtained for including hypoechogenicity, increased thickness of the tendon insertion, calcifications, enthesophytes, erosions, Doppler activity as elementary lesions enthesitis. US each...
<h3>Objective</h3> Enthesopathy is a major feature of psoriatic arthritis (PsA), which supported by imaging studies. Given that nail disease often predates PsA and the directly anchored to entheses, authors asked whether involvement in psoriasis equates with systemic enthesopathy. <h3>Methods</h3> Forty-six patients (31 disease) 21 matched healthy controls (HC) were recruited. 804 entheses upper lower limbs scanned an ultrasonographer blinded clinical details. <h3>Results</h3> Psoriasis had...
<b><i>Objective:</i></b> We compared ultrasonography (US) with the modified nail psoriasis severity index (mNAPSI) to investigate plate, matrix and adjacent tendons in subjects psoriatic disease test hypothesis that involvement was specifically linked extensor tendon enthesopathy. <b><i>Methods:</i></b> 86 patients (169 nails) 20 healthy controls (HC) (40 were assessed both mNAPSI US. The thickness of region physical examination findings....
Objective Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome‐wide association analysis of arteritis. Methods Two independent cohorts patients from Turkey and North America were included in our study. The Turkish cohort consisted 559 489 controls, American 134 1,047 controls European ancestry. Genotyping performed using Omni1‐Quad Omni2.5 genotyping arrays. data subjected rigorous quality...
<h3>Objectives</h3> Skin and joint involvement in psoriasis (PsO) psoriatic arthritis (PsA) are thought to relate the so-called Koebner response. Given that dactylitis is non-randomly distributed digits, this study tested hypothesis accessory pulleys linked flexor tendons were thickened PsA thus exhibited koebnerisation. <h3>Methods</h3> Ninety-six subjects (27 PsA, 27 rheumatoid (RA), 23 PsO 19 healthy controls (HCs)) enrolled. The A1, A2 A4 pulley thickness was measured using a...
Objectives The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and test its reliability. To this end, we assessed the validity, feasibility applicability of ultrasound assessment finger entheses incorporate them into scoring system. Methods study consisted stepwise process. First, cadaveric specimens, identified enthesis sites fingers by gross anatomy, then verified presence entheseal tissue histological samples. We selected be...
To develop a consensus-based expert definition of difficult-to-manage (D2M) axial spondyloarthritis (axSpA), incorporating treatment-refractory (TR) disease. A literature review was conducted in 2022 to identify potential definitions for D2M/TR axSpA from prior studies, followed by 2-round Delphi consensus process and 2023 components D2M axSpA. Based on the results process, draft developed presented task force, including patient representation, and, subsequently, Assessment SpondyloArthritis...
There has been a marked increase in the past 15 years number and quality of clinical trials idiopathic inflammatory vasculitides, especially small-vessel vasculitides known as antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis [AAV; granulomatosis, with polyangiitis (Wegener's)]. These have conducted by multicenter, international groups Europe United States financial support provided government agencies biopharmaceutical companies. This increased trial activity accompanied...
Objective. Disease Extent Index-Takayasu (DEI.Tak) is a new index developed for the follow-up of Takayasu's arteritis (TA), assessing only clinical findings without requirement imaging. We investigated effectiveness DEI.Tak in disease activity and progression by comparing with physician's global assessment (PGA) active criteria defined Kerr et al.
<h3>Background</h3> Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome clinical trials. Nevertheless, an objective, validated biomarker skin fibrosis lacking. Optical coherence tomography (OCT) imaging technology providing high-contrast images with 4 μm resolution, comparable microscopy ('virtual biopsy'). The present study evaluated OCT to detect quantify SSc. <h3>Methods</h3> We performed 458 scans hands forearms on 21 SSc patients 22...
Objective Subclinical enthesopathy is recognised in both psoriasis and psoriatic arthritis (PsA). This study used ultrasonography with power Doppler (PD) to test the hypothesis that subclinical PsA was associated an ‘inflammatory’ or vascular phenotype compared seen psoriasis. Methods 100 patients a mean age of 46.3 years (SD 15) (42 58 PsA) 23 matched healthy controls (HC) from two centres were included. 1230 lower limb entheses scanned by ultrasonographers blinded clinical details. Both...
Background The new Assessment of SpondyloArthritis international Society (ASAS) criteria classify axial spondyloarthritis (SpA) into human leucocyte antigen-B27 and/or imaging-based arms. To aid implementation, ASAS has proposed a definition positive MRI for active sacroiliitis. Objective authors aimed to test the diagnostic and predictive value ‘positive’ MRI. Methods Baseline scans on 29 patients with early inflammatory back pain 18 controls were read independently by four experienced...
HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they associated different vasculitides (HLA-B*51 in Behçet's disease Takayasu's arteritis (TAK)) major clinical immunological In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence as susceptibility severity factors.TAK (n = 330) followed at total 15 centers were included study. The mean age was 37.8 years, 86% women. DNA samples...
Background The objective was to compare different definitions of remission and low disease activity (LDA) in patients with psoriatic arthritis (PsA), based on both patients’ physicians’ perspectives. Methods In ReFlap (Remission/Flare PsA; NCT03119805 ), adults physician-confirmed PsA >2 years duration 14 countries were included. Remission defined as very (VLDA), Disease Activity index for PSoriatic Arthritis (DAPSA) ≤4, physician-perceived patient-perceived (specific question yes/no),...
Objective. To assess the performance of various sonographic elemental entheseal lesions in distinguishing between psoriatic arthritis (PsA) and controls to inform development a novel enthesitis score for PsA. Methods. A total 100 age- sex-matched individuals (50 PsA 50 controls) were evaluated. Eleven sites scanned bilaterally according standardized protocol by 2 sonographers. Based on Outcome Measures Rheumatology (OMERACT) definition enthesitis, following assessed: structural changes...