A5054073726- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Musculoskeletal synovial abnormalities and treatments
- Mast cells and histamine
- Orthopedic Surgery and Rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Inflammatory Bowel Disease
- Bone and Joint Diseases
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- Streptococcal Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Dermatological and Skeletal Disorders
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Vasculitis and related conditions
- Dupuytren's Contracture and Treatments
- Blood disorders and treatments
- Microscopic Colitis
- Skin and Cellular Biology Research
- Blood Coagulation and Thrombosis Mechanisms
Ospedale Sacro Cuore Don Calabria
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Sacred Heart Hospital
2023
Center for Rheumatology
2023
Hacettepe University
2021
NIHR Leeds Musculoskeletal Biomedical Research Unit
2010-2021
University of Leeds
2010-2021
University of Verona
2006-2020
Ege University
2019
Marmara University
2019
Psoriasis is associated with a form of spondyloarthropathy in 10-30% cases. A major feature psoriatic arthritis enthesitis. In some patients psoriasis the presence enthesitis could be underdiagnosed.To investigate lower limbs entheseal abnormalities chronic plaque without signs and symptoms arthritis.Thirty 30 controls underwent ultrasonographic evaluation Achilles, quadriceps, patellar entheses plantar aponeurosis. Ultrasonographic findings were scored according to Glasgow Ultrasound...
<h3>Background</h3> The transition from psoriasis (PsO) to psoriatic arthritis (PsA) and the early diagnosis of PsA is considerable scientific clinical interest for prevention interception PsA. <h3>Objective</h3> To formulate EULAR points consider (PtC) development data-driven guidance consensus trials practice in field or management people with PsO at risk development. <h3>Methods</h3> A multidisciplinary task force 30 members 13 European countries was established, standardised operating...
<h3>Objective</h3> Enthesopathy is a major feature of psoriatic arthritis (PsA), which supported by imaging studies. Given that nail disease often predates PsA and the directly anchored to entheses, authors asked whether involvement in psoriasis equates with systemic enthesopathy. <h3>Methods</h3> Forty-six patients (31 disease) 21 matched healthy controls (HC) were recruited. 804 entheses upper lower limbs scanned an ultrasonographer blinded clinical details. <h3>Results</h3> Psoriasis had...
Objective. Dermatologists usually see patients with psoriasis before arthritis develops, making them well placed to diagnose early PsA (ePsA). This study aimed develop a rapid and robust screening questionnaire for predicting in referred specialized joint dermatology–rheumatology combined clinic. Methods. In all, 228 naïve DMARD treatment were administered two questionnaire: the new Early ARthritis Psoriatic (EARP) existing Arthritis Screening Evaluation (PASE) questionnaire. The diagnostic...
<h3>Objectives</h3> Skin and joint involvement in psoriasis (PsO) psoriatic arthritis (PsA) are thought to relate the so-called Koebner response. Given that dactylitis is non-randomly distributed digits, this study tested hypothesis accessory pulleys linked flexor tendons were thickened PsA thus exhibited koebnerisation. <h3>Methods</h3> Ninety-six subjects (27 PsA, 27 rheumatoid (RA), 23 PsO 19 healthy controls (HCs)) enrolled. The A1, A2 A4 pulley thickness was measured using a...
Non-specific musculoskeletal pain is common in subjects destined to develop psoriatic arthritis (PsA). We evaluated patients with arthralgia (PsOAr) compared psoriasis alone (PsO) and healthy controls (HCs) using ultrasonography (US) investigate the anatomical basis for joint symptoms PsOAr link between these imaging findings subsequent PsA transition.A cross-sectional prevalence analysis of clinical US abnormalities (including inflammatory structural lesions) (n=61), PsO (n=57) HCs was...
Subjects with subclinical psoriatic arthritis (PsA), defined as the presence of arthralgia in psoriasis (PsO), are at higher risk PsA but scant real-world data exist. Our aims were to (1) estimate probability development PsA, (2) characterise symptoms and (3) determine clinical patterns diagnosis.
Objectives The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and test its reliability. To this end, we assessed the validity, feasibility applicability of ultrasound assessment finger entheses incorporate them into scoring system. Methods study consisted stepwise process. First, cadaveric specimens, identified enthesis sites fingers by gross anatomy, then verified presence entheseal tissue histological samples. We selected be...
Abstract TNF-like cytokine (TL1A) is a newly identified member of the TNF superfamily ligands that important for T cell costimulation and Th1 polarization. However, despite increasing information about its functions, very little known expression TL1A in normal or pathological states. In this study, we report mononuclear phagocytes appear to be major source rheumatoid arthritis (RA), as revealed by their strong either synovial fluids tissue factor (RF)-seropositive RA patients, but not RF−/RA...
Objective Subclinical enthesopathy is recognised in both psoriasis and psoriatic arthritis (PsA). This study used ultrasonography with power Doppler (PD) to test the hypothesis that subclinical PsA was associated an ‘inflammatory’ or vascular phenotype compared seen psoriasis. Methods 100 patients a mean age of 46.3 years (SD 15) (42 58 PsA) 23 matched healthy controls (HC) from two centres were included. 1230 lower limb entheses scanned by ultrasonographers blinded clinical details. Both...
Vedolizumab (VDZ) blocks α4β7 integrin and is licenced for the treatment of IBD. It has been associated with mild SpA-related features, including sacroiliitis synovitis. Herein we report a series cases demonstrating emergence severe SpA-associated enthesitis/osteitis following successful IBD therapy VDZ.We evaluated 11 VDZ-treated patients across seven centres who developed active SpA and/or enthesopathy, aim characterizing VDZ-associated or entheseal flares. Imaging features particularly...
Abstract Introduction Dactylitis is a hallmark of psoriatic arthritis (PsA). While its assessment clinical, recently musculoskeletal ultrasonography (MSUS) has been applied to monitoring. However, the evidence on MSUS application for toe dactylitis limited. The aim this study characterize ultrasonographic features in PsA. Method Patients with PsA and painful were retrospectively identified from clinical records. Demographic variables analyzed. Ultrasound images affected toe, allowing grey...
Caveolin-1 (CAV1) is an inhibitor of tissue fibrosis and has been implicated in the pathogenesis systemic sclerosis (SSc). The aim study was to analyse possible association CAV1 gene single nucleotide polymorphisms (SNP) with SSc.A total population 3974 individuals (1355 SSc patients, 2619 controls) studied. Genotype data for 23 SNP spanning CAV1-CAV2 locus were obtained from a genome-wide scan conducted French (564 1776 controls). Three (rs926198, rs959173, rs9920) displaying most...
Abstract Objective The digital accessory pulleys are highly mechanically stressed mini-entheses that thickened in patients with a history of PsA-related dactylits. This study explored whether these involved PsA dactylitis as assessed by intra-pulley US power Doppler changes. Methods Fifty-eight had the second to fourth digits for dactylitic and contralateral digits. Leeds Dactylometer was used thickness measurement. presence pain, tenderness, swelling finger side evaluated. Results We...