A5102010249- Immune Cell Function and Interaction
- Immune cells in cancer
- Immune Response and Inflammation
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Public Health in Brazil
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- COVID-19 Impact on Reproduction
- Youth, Drugs, and Violence
- Cancer Cells and Metastasis
- Augmented Reality Applications
- Acupuncture Treatment Research Studies
- Surgical Sutures and Adhesives
- Cholesterol and Lipid Metabolism
- Mathematical Dynamics and Fractals
- COVID-19 and healthcare impacts
- Memory and Neural Mechanisms
- Lipoproteins and Cardiovascular Health
- Educational Practices and Policies
- Inflammatory Biomarkers in Disease Prognosis
- Autopsy Techniques and Outcomes
- Indigenous Studies in Latin America
- Face Recognition and Perception
University of Verona
2013-2024
Universidade Estadual de Maringá
2024
University of Parma
2023-2024
Hospital de Santo António
2024
National Legal Medicine Institute
2022
University of Padua
2017
General Department of Preventive Medicine
2017
University of Campania "Luigi Vanvitelli"
2017
Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition mature and immature lack specific markers. Here, we focus on CD66b+CD10+CD16+CD11b+ PMN-MDSCs (mPMN-MDSCs) from either cancer patients or healthy donors receiving G-CSF for stem cell mobilization (GDs). By RNA sequencing (RNA-seq) experiments, report the identification a distinct gene signature shared different mPMN-MDSC populations under...
Controversy currently exists about the ability of human neutrophils to produce IL-6. Here, we show that chromatin organization IL-6 genomic locus in is constitutively kept an inactive configuration. However, also upon exposure stimuli trigger remodelling at locus, such as ligands for TLR8 or, less efficiently, TLR4, highly purified express and secrete In TLR8-activated neutrophils, but not monocytes, expression preceded by induction a latent enhancer located 14 kb upstream transcriptional...
Objetivo: descrever o processo de introdução alimentar crianças nascidas com fissura labiopalatal. Método: estudo descritivo abordagem qualitativa, realizado em uma Associação Apoio ao Fisssurado Labiopalatal. A coleta dados foi realizada no período maio a julho 2022, por meio entrevistas audiogravadas, posteriormente transcritas e analisadas seguindo técnica Análise Conteúdo Bardin. O aprovado pelo Comitê Permanente Ética Pesquisa Seres Humanos parecer nº 4.095.950. Resultados: participaram...
Abstract Terminal tissue differentiation and function of slan+ monocytes in cancer is largely unexplored. Our recent studies demonstrated that differentiate into a distinct subset dendritic cells (DC) human tonsils colonize metastatic carcinoma-draining lymph nodes. Herein, we report by retrospective analysis multi-institutional cohorts infiltrate various types non-Hodgkin lymphomas (NHL), particularly the diffuse large B-cell lymphoma (DLBCL) group, including most aggressive, nodal...
The use of virtual reality (VR) for industrial training helps minimize risks and costs by allowing more frequent varied experiential learning activities, leading to active improved learning. However, creating VR experiences is costly time-consuming, requiring software development experts. Additionally, current authoring tools lack integration with existing data are desktop-oriented, which detach the pedagogic process immersive experience from experiencing it in a situated context. In this...
Psoriasis is a chronic skin disease associated with deregulated activation of immune cells and keratinocytes. In this study, we used the imiquimod (IMQ)-induced mouse model psoriasis to dissect better contribution hematopoietic skin-resident stromal development. The comparison development in mice carrying cell-specific deletion MyD88 (Myd88fl/flVav-cre+ mice) total deficiency (Myd88-/- mice), show that progression systemic inflammation, as well epidermal thickening, was completely dependent...
Abstract Simulation theories predict that the observation of other’s expressions modulates neural activity in same centres controlling their production. This hypothesis has been developed by two models, postulating visual input is directly projected either to motor system for action recognition (motor resonance) or emotional/interoceptive regions emotional contagion and social synchronization (emotional resonance). Here we investigated role frontal/insular processing observed combining...
There is increasing evidence supporting the notion that neutrophils and other leukocytes establish cooperative actions in regulating innate adaptive immune responses. In such a context, we have shown recently human amplify NK cell/slanDC-mediated cytokine production by directly costimulating IFN-γ cells, as well potentiating IL-12p70 release slanDCs via CD18/ICAM-1 interactions. To gain more insights into molecular bases of neutrophil-mediated potentiation cells under coculture conditions,...
Psoriasis is a chronic skin disease associated with deregulated interplays between immune cells and keratinocytes. Neutrophil accumulation in the histological feature that characterizes psoriasis. However, role of neutrophils psoriasis onset development remains poorly understood.In this study, we utilized model psoriasiform dermatitis, caused by repeated topical application an imiquimod containing cream, neutrophil-depleted mice or carrying impairment neutrophil functions, including p47phox...
Executive function (EF) describes a group of cognitive processes underlying the organization and control goal-directed behaviour. Environmental experience appears to play crucial role in EF development, with early psychosocial deprivation often linked impairment. However, many questions remain concerning developmental trajectories after exposure deprivation, especially specific mechanisms. Accordingly, using an 'A-not-B' paradigm macaque model we investigated how influences development...
The advent of immune checkpoint inhibitors (ICIs), for instance, programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) blockers, has greatly improved the outcome patients affected by non-small lung cancer (NSCLC). However, most NSCLC either do not respond to ICI monotherapy or develop resistance it after an initial response. Therefore, identification biomarkers predicting response represents urgent issue. Great efforts are currently dedicated toward identifying blood-based predict responses...
Verificamos uma atual preocupacao internacional relativamente a influencia do consumo de alcool na saude publica, e como estes padroes se refletem nas diversas fases desenvolvimento individuo. Em Portugal, o seu excessivo fazer parte integrante percurso academico, em que os estudos as aplicacoes praticas sao reduzidas, apesar da sua relevância academico repercussoes vida adulta. No presente trabalho pretendemos avaliar caraterizar habitos alcool, entender relacao entre ao longo suas...
Estudantes internacionais, geralmente, vivenciam enfrentamentos ao estarem inseridos em um modelo educacional e país distintos daqueles de origem. O objetivo desse estudo foi compreender a trajetória vida estudantes internacionais antes após o ingresso uma universidade pública brasileira. A história oral constitui referencial teórico para interpretação dos dados. Participaram 15 no sul do Brasil, que tinham habilidade se comunicar língua portuguesa. coleta dados ocorreu entre janeiro março...
Objetivo: Aprender como foi experienciar o nascimento de um filho durante a pandemia da COVID-19. Método: estudo qualitativo cujos dados foram coletados em setembro 2021, mediante entrevistas semi-estruturadas, audiogravadas, com 11 mães e submetidos à análise conteúdo, modalidade temática. Resultados: emergiram duas categorias, as quais mostram que do vivenciado forma restritiva suscitou sentimentos medo, ansiedade, preocupação, frustração, mas também alívio, felicidade superação. A...
Trata-se de um estudo transversal, descritivo e analítico que utilizou dados secundários da base vigilância epidemiológica domínio público no Brasil, período dezembro 2021 a julho 2022. O objetivo do foi analisar os casos SRAG associada covid-19 em gestantes foram hospitalizadas unidade terapia intensiva (UTI) Brasil. A amostra constituída por 239 tiveram COVID-19 internadas UTI, sendo 205 com descrição desfecho final 34 sem caso. Para análise estatística, importados para o programa R versão...
Objetivo: Descrever o perfil epidemiológico de recém-nascidos internados em unidade terapia intensiva neonatal durante pandemia pela Covid-19. Métodos: Estudo quantitativo, descritivo, exploratório e retrospectivo. Os dados foram coletados por meio buscas prontuários hospitalizados utilizando um instrumento estruturado no período junho a dezembro 2022. A análise estatística foi realizada com auxílio do software SPSS os resultados apresentados tabelas. Resultados: Foram analisados 192...
Keypoints:• Some characteristic findings allow the identification of self-inflicted lesions.are several features which forensic pathologist to discard a homicide hypothesis.• However, some suicides with bladed instruments may result in atypical injuries.• When fatal incised and/or stab wounds are present, close analysis case is crucial order safely sustain suicide diagnosis.
<p>The file contains 8 supplementary Figures displaying results in support of the data described section.</p>
<p>The file contains 8 supplementary Figures displaying results in support of the data described section.</p>