A5033590638- Sarcoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Orthopedic Infections and Treatments
- Glioma Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Glaucoma and retinal disorders
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Statistical Methods in Clinical Trials
- Ocular Surface and Contact Lens
- Health Systems, Economic Evaluations, Quality of Life
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- Pharmaceutical Practices and Patient Outcomes
- Ocular Oncology and Treatments
- Diversity and Career in Medicine
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
- Ocular Infections and Treatments
- Meningioma and schwannoma management
- Cardiovascular Syncope and Autonomic Disorders
Institut Gustave Roussy
2017-2024
Inserm
2014-2024
Université Paris-Saclay
2017-2024
University of Diyala
2024
Centre de recherche en Epidémiologie et Santé des Populations
2017-2023
Université Paris-Sud
2017-2023
La Ligue Contre le Cancer
2021-2023
Roche (Switzerland)
2023
Hôpital Bichat-Claude-Bernard
2015-2022
Assistance Publique – Hôpitaux de Paris
2015-2022
Immunotherapy with chimeric antigen receptor (CAR)-expressing T cells that target the disialoganglioside GD2 expressed on tumor may be a therapeutic option for patients high-risk neuroblastoma.In an academic, phase 1-2 clinical trial, we enrolled (1 to 25 years of age) relapsed or refractory, neuroblastoma in order test autologous, third-generation GD2-CAR expressing inducible caspase 9 suicide gene (GD2-CART01).A total 27 children heavily pretreated (12 refractory disease, 14 and 1 complete...
Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer's disease. Gantenerumab is a subcutaneously administered, fully human, anti-Aβ IgG1 monoclonal antibody highest affinity for aggregated Aβ has been tested treatment of Download PDF Research Summary. We conducted two phase 3 trials (GRADUATE I II) involving participants 50 90 years age mild impairment or dementia due disease evidence amyloid plaques...
Germline mutations of suppressor fused homolog (SUFU) predispose to sonic hedgehog (SHH) medulloblastoma. SUFU have been reported in nevoid basal cell carcinoma syndrome (NBCCS), but little is known about the cancer risk and clinical spectrum.We performed a retrospective review all patients with medulloblastoma germline mutation France.Twenty-two from 17 families were identified (median age at diagnosis: 16.5 mo). Macrocrania was present 20 patients, only 5 met diagnostic criteria for NBCCS....
Background: Occupational skin dermatosis is of a significant concern among dental lab technicians due to their exposure chemicals and materials used in prosthetics. These exposures can lead various conditions, impacting the health productivity workforce. To determine prevalence, clinical features associated factors occupational Khartoum State from 2023 2024. Methods: A descriptive, observational, cross-sectional study was conducted 171 State. Data collection involved structured...
The purpose of this work is to assess the clinical outcome pediatric patients diagnosed with pheochromocytoma and paraganglioma (PPGL) detected in France since 2000.A retrospective multicenter study was conducted that included all younger than 18 years PPGL between 2000 2016. Patients were identified from 4 different sources: National Registry Childhood Solid Tumors, French Pediatric Rare Tumors Database, registry succinate dehydrogenase (SDH)-related hereditary paraganglioma, nationwide...
Abstract The outcomes of adolescents/young adults with osteosarcoma have not improved in decades. chaotic karyotype this rare tumor has precluded the identification prognostic biomarkers and patient stratification. We reasoned that transcriptomic studies should overcome genetic complexity. RNA sequencing (RNA-seq) 79 diagnostic biopsies identified stable independent components recapitulate microenvironment cell composition. Unsupervised classification stratified cohort into favorable (G1)...
Describe clinical characteristics and outcome of Li-Fraumeni syndrome (LFS)-associated osteosarcomas.
Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates risk for CVD this population. Our study aimed to determine whether serum high-sensitivity cardiac troponin T (HS-cTnT) might help identify SLE patients at CVD.The presence carotid plaques was prospectively assessed by ultrasound 63 consecutive asymptomatic and 18 controls. Serum HS-cTnT concentration measured using electrochemiluminescence method. Factors...
Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been attempted in last years without significant effect on OS. Although radiological imaging gold standard for DIPG diagnosis, urgent need to improve has led reconsideration biopsy aim better understand molecular profile and support personalized...
Abstract Male-to-female transgender (MtF TG) individuals often report using illegal subcutaneous silicone injections for body feminisation. It leads to dissemination and various dermatologic complications. We the long-term complications of these feminisation procedures with blood smear examination examination. Between July 2015 December 2015, 77 MtF TG consulting at Bichat Hospital (Paris, France) were included in this cross-sectional study. Blood examinations performed by a trained...
Objective: This study aimed to determine whether sCD163, a soluble macrophage marker up-regulated in numerous inflammatory disorders, is predictive of accelerated atherosclerosis associated with systemic lupus erythematosus (SLE).Methods: Carotid ultrasound was prospectively performed, at baseline and during follow-up, 63 consecutive SLE patients asymptomatic for cardiovascular disease (CVD) 18 volunteer health workers. Serum sCD163 level determined using enzyme-linked immunosorbent assay....
Abstract Background Previous pilot studies have shown the feasibility of preoperative chemotherapy in patients with medulloblastoma, but benefits and risks compared initial surgery not been assessed. Methods Two therapeutic strategies were retrospectively 92 metastatic medulloblastoma treated at Gustave Roussy between 2002 2015: diagnosis (n = 54, group A) delayed after carboplatin etoposide-based neoadjuvant therapy 38, B). Treatment similar both groups. Results The rate complete tumor...
Given the very poor prognosis for children with recurrent medulloblastoma, we aimed to identify prognostic factors survival post-relapse in childhood medulloblastoma. We retrospectively collected clinico-biological data at diagnosis and main clinical characteristics relapse of newly diagnosed a medulloblastoma between 2007 2017 Gustave Roussy Necker Hospital. At median follow-up 6.6 years (range, 0.4–12.3 years), occurred 48 out 155 patients (31%). The time from was 14.3 months 1.2–87.2...
Acute pericarditis may be the heralding manifestation of various systemic inflammatory diseases (SIDs). The aim this study was to identify clinical indicators for SIDs in patients admitted acute with pericardial effusion.All consecutive adult hospitalized a Department Internal Medicine over 10-year period effusion were retrospectively reviewed. Patients cancer and tuberculosis excluded. A structured panel extra-cardiac symptoms applied. classified using current international...
Previous studies have shown that neutrophil-to-lymphocyte (NLR) ratio at diagnosis and early lymphocytes recovery on doxorubicin-based chemotherapy, may impact the outcome in patients with osteosarcoma (OST). This study aimed to evaluate prognostic value of hemogram parameters OST treated high-dose methotrexate etoposide/ifosfamide (M-EI) chemotherapy.
3027 Background: NER (HKI-272) is an irreversible pan-ErbB tyrosine kinase inhibitor with antitumor activity in pts HER2-amplified tumors. TEM inhibits mTOR (TORC1). Hyperactivation of the PI3K-Akt-mTOR axis mediates resistance to anti-HER2 therapies. Preclinical data mouse models HER2-driven cancers suggest that combination both and HER2 inhibitors improves anti-tumor efficacy compared inhibition alone. Methods: This open-label trial evaluated safety, pharmacokinetics (PK), preliminary plus...
Summary Relapses involving the central nervous system (CNS) are rare in children and adolescents with ALK+ anaplastic large cell lymphoma (ALCL) treated regimens including CNS prophylaxis. Early identification of patients at high‐risk for relapse would enable stratification better adaptation initial treatment especially light upcoming targeted therapies limited penetration. We analyzed clinical histological data all ALK+ALCL registered ALCL99‐database aim to describe risk factors outcome....
During simultaneous liver-kidney transplantation (SLK) in highly sensitized patients, donor specific anti-human leukocyte antigen antibodies (DSA, HLA) can be present prior to transplant leading positive crossmatch, yet these recipients have relatively low incidences of acute rejection. The mechanisms and timing underlying immunologic changes that occur intra-operatively remain largely unknown. Therefore, we measured the intra- peri-operative kinetics anti-HLA SLK recipients. In this study,...
In anaplastic lymphoma kinase (ALK)-positive large cell (ALK+ ALCL), positive minimal residual disease (MRD+) after the first chemotherapy course was proven of strong prognostic significance. We aimed to validate these results in 138 French patients. Eighty-seven patients had a detectable disseminated at diagnosis (MDD+). Early MRD assessment performed 33 87 and 18 negative 15 (MRD-). Three-year progression-free survival significantly correlated with MDD/MRD status: 81.1% MDD-, 69.6%...
<h3>ABSTRACT</h3> Acute meningitis can be the first manifestation of an underlying systemic inflammatory disorder (SID). In current study, we aimed to identify clinical indicators for SIDs in patients admitted acute aseptic meningitis. All hospitalised over a 4-year period department internal medicine were included retrospectively. Patients with neoplastic excluded. Extraneurological signs recorded using systematic panel. Systemic diagnosis was made according international criteria....