A5073667939- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Neuroblastoma Research and Treatments
- Family Support in Illness
- Cancer-related Molecular Pathways
- Hedgehog Signaling Pathway Studies
- Acute Myeloid Leukemia Research
- Adolescent and Pediatric Healthcare
- Lymphoma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Neurofibromatosis and Schwannoma Cases
- Chronic Myeloid Leukemia Treatments
- Cancer Risks and Factors
- HIV Research and Treatment
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- Renal and related cancers
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Ubiquitin and proteasome pathways
- Congenital Diaphragmatic Hernia Studies
- Blood disorders and treatments
- Cancer-related cognitive impairment studies
Université Grenoble Alpes
2016-2025
Centre National de la Recherche Scientifique
2022-2025
Inserm
2021-2025
Centre Hospitalier Universitaire de Grenoble
2016-2024
McGill University Health Centre
2023-2024
Montreal Children's Hospital
2023-2024
Health and Human Development (2HD) Research Network
2024
Hôpital Couple Enfant
2017-2023
European Organisation for Research and Treatment of Cancer
2022
CHR Verviers
2022
<h3>Importance</h3> Li-Fraumeni syndrome is a cancer predisposition that associated with high, lifelong risk of broad spectrum cancers caused by pathogenic<i>TP53</i>germline variants. A definition reflects the phenotypic has evolved since gene discovery lacking, and mechanisms leading to differences remain largely unknown. <h3>Objective</h3> To define conduct phenotype-genotype associations across spectrum. <h3>Design, Setting, Participants</h3> We analyzed classified germline variant data...
The purpose of this work is to assess the clinical outcome pediatric patients diagnosed with pheochromocytoma and paraganglioma (PPGL) detected in France since 2000.A retrospective multicenter study was conducted that included all younger than 18 years PPGL between 2000 2016. Patients were identified from 4 different sources: National Registry Childhood Solid Tumors, French Pediatric Rare Tumors Database, registry succinate dehydrogenase (SDH)-related hereditary paraganglioma, nationwide...
Abstract Growing evidence suggests that polymorphisms of genes coding for transporters or enzymes may partially explain the large between subject variability reported methotrexate (MTX) pharmacokinetics (PK). This prospective study aimed to develop a population PK‐pharmacogenetic model evaluate part between‐subject due single‐nucleotide (SNPs) in and enzyme implicated MTX distribution elimination. concentrations 54 SNPs (located ABCB1 , ABCC1 ABCC2 ABCC3 ABCC4 ABCG2 SLC19A1 SLCO1B1 UGT1A1...
Survival after childhood acute lymphoblastic leukemia (ALL) has increased over the last 40 years with an overall survival above 90%. Survivors may experience neurological late effects secondary to chemotherapy and radiotherapy. This observational retrospective study evaluated cumulative incidence of among 890 ALL survivors treated in EORTC CLG trials (58741, 58831/2 58881) between 1971 1998. Median follow-up was 19 interquartile range 15-22 years. At 20 from end treatment, approximately 66%...
Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population‐based, case–control to investigate association between maternal residential use pesticides and risk CBT. The mothers 437 CBT cases 3,102 controls aged under 15 years who resided France at diagnosis/interview, frequency‐matched by age gender, answered structured telephone...
Little is known of the causes childhood brain tumors (CBT). The aims this study were to investigate whether extremes birth weight associated with increased risk CBT and maternal preconceptional folic acid supplementation or breastfeeding reduced risk. In addition, other characteristics related factors also investigated. We pooled data from two French national population-based case-control studies similar designs conducted in 2003-2004 2010-2011. mothers 510 cases (directly recruited cancer...
To describe fecundity in female survivors of childhood cancer and consider the correlation with quality life (QOL).Of 1744 women treated for before age 15 years at one eight French treatment centers between 1948 1992, 1187 who were alive 2005 sent a self-administered questionnaire, including questions about health status, QOL (MOS SF-36), fecundity. A standardized ratio (SFR) was calculated (SFR: observed/expected number children) each individual based on national reference.Of 972...
Summary Among 143 patients with elastase, neutrophil‐expressed ( ELANE )‐related neutropenia enrolled in the French Severe Chronic Neutropenia Registry, 94 were classified as having severe chronic (SCN) and 49 cyclic (CyN). Their infectious episodes severe, mild or oral, analysed according to their natural occurrence without granulocyte‐colony stimulating factor (G‐CSF), on G‐CSF, after myelodysplasia/acute leukaemia haematopoietic stem‐cell transplantation. During disease’s history period...
Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need elucidate long-term quality life (QoL) and domains complaints in these patients. Furthermore, main priorities patients be clarified. We assessed QoL childhood ALL compared matched population controls.QoL data were collected from recruited France Belgium between 2012 2017, including Short Form Health Survey (SF-12) Quality Life...
Purpose: This study evaluated the long-term psychological impact of childhood cancer and also sought to identify risk factors in development issues. Methods: Young adult (18-38 years) survivors a (except leukemia), diagnosed younger than 15 years between 1987 1999 Rhône-Alpes region France, were invited semistandardized interview after medical follow-up consultation during two successive studies Oncology (SALTO-1 -2). Psychiatric issues from DSM-IV compared with general French population...
Abstract Introduction Our objectives were to assess the quality of life (QoL) parents childhood leukemia survivors compared with population norms and identify determinants parents’ long‐term QoL. Methods Parents minors who had survived participating in French LEA cohort (Leucémie de l'Enfant et l'Adolescent—French Childhood Cancer Survivor Study for Leukemia) asked complete version WHOQOL‐BREF. Results age‐ sex‐matched values from a reference population. Parents’ survivors’ characteristics...
We compared the long-term impact of donor type (sibling [SD] versus matched unrelated [MUD] or umbilical cord blood [UCB]) on late side effects and quality life (QoL) in childhood acute leukemia survivors treated with hematopoietic stem cell transplantation. included 314 patients who underwent transplantation from 1997 to 2012 were enrolled multicenter French Leucémie de l'Enfant et L'Adolescent ("Leukemia Children Adolescents") cohort. More than one-third adults at last visit; mean...
We evaluated the satisfaction of adult survivors childhood cancers and their general practitioners (GP) after a long-term consultation.The first Long-term Follow-up Study in Oncology (SALTO1) is prospective cohort study (except leukemia) diagnosed between 1987 1992 Rhône-Alpes Auvergne regions France. Of 481 patients eligible for study, 150 participated consultation with pediatric oncologist an internist, which GPs received plans recommendations based on findings. A year consultation,...
Survival of childhood, adolescent and young adult (CAYA) cancers has increased with progress in the management treatments reached more than 80% at 5 years. Nevertheless, these survivors are great risk second non-malignant co-morbidities later life. DeNaCaPST is a non-interventional study whose aim to organize national screening for thyroid cancer breast CAYA cancers. It will compliance international recommendations, aim, regarding programme, offering every woman living France, equal risk, an...
due to increasing survival rates in childhood acute lymphoblastic leukemia (ALL), the number of survivors has been expanding. A significant proportion these can experience long-term emotional and psychosocial problems. However, exact risk factors remain inconclusive. We investigated potential for decreased daily life quality challenges ALL enrolled between 1971 1998 EORTC studies.self-report questionnaires were collected from 186 (109 females; mean age at diagnosis 5.62 years, range...