A5078174118- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Carcinogens and Genotoxicity Assessment
- Genetic Neurodegenerative Diseases
- Air Quality and Health Impacts
- Occupational exposure and asthma
- Indoor Air Quality and Microbial Exposure
- Mitochondrial Function and Pathology
- Cancer Risks and Factors
- Allergic Rhinitis and Sensitization
- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Lymphoma Diagnosis and Treatment
- Noise Effects and Management
- Epigenetics and DNA Methylation
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Pesticide Exposure and Toxicity
- Prion Diseases and Protein Misfolding
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Health, Environment, Cognitive Aging
- Neuroblastoma Research and Treatments
- Respiratory and Cough-Related Research
Centre de recherche en Epidémiologie et Santé des Populations
2012-2025
Université de Versailles Saint-Quentin-en-Yvelines
2020-2025
Université Paris-Saclay
2007-2025
Inserm
2015-2024
Université Paris-Sud
2010-2024
Inserm Transfert
2024
Centre de Recherche Épidémiologie et Statistique
2015-2020
Délégation Paris 5
2015-2019
Université Paris Cité
2007-2019
Sorbonne Paris Cité
2015-2019
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control in Childhood Leukemia International Consortium. Exposure were harmonized into compatible formats. Pooled analyses undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with...
The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation the immune system, that is, day-care center attendance, birth order, maternally reported common infections in infancy, breastfeeding, were investigated by using data from 11 case-control studies participating Childhood Leukemia International Consortium (enrollment period: 1980–2010). sample included 7,399 ALL cases 11,181 controls aged 2–14 years. collected questionnaires...
Maternal occupational pesticide exposure during pregnancy and/or paternal around conception have been suggested to increase risk of leukemia in the offspring. With a view providing insight this area we pooled individual level data from 13 case‐control studies participating Childhood Leukemia International Consortium (CLIC). Occupational were harmonized compatible format. Pooled analyses undertaken using unconditional logistic regression. Using mothers 8,236 cases, and 14,850 controls,...
This study investigated the role of factors considered related to early stimulation immune system in etiology childhood acute leukemia. The national registry-based case-control ESCALE was carried out France 2003–2004. Population controls were frequency matched cases on age and gender. Data obtained from structured telephone questionnaires administered mothers. Odds ratios estimated using unconditional regression models adjusted for potential confounders. Included 634 lymphoblastic leukemia...
Objectives: Investigating the relationship between occupational exposure to pesticides and risk of lymphoid neoplasms (LNs) in men. Methods: A hospital-based case-control study was conducted six centres France 2000 2004. The cases were incident with a diagnosis LN aged 18–75 years. During same period, controls age sex as recruited hospital, mainly orthopaedic rheumatological departments. Exposures evaluated through specific interviews case-by-case expert reviews. Four hundred ninety-one (244...
Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, large number environmental chemicals are suspected playing role in cancer. The identification occupations or occupational exposures associated with an increased incidence men may help identify mammary carcinogens the environment.Occupational factors for male were investigated multi-centre case-control study conducted eight European countries which included 104 cases...
Positive associations have been reported between the measures of accelerated fetal growth and risk childhood acute lymphoblastic leukemia (ALL). We investigated this association by pooling individual-level data from 12 case-control studies participating in Childhood Leukemia International Consortium. Two growth-weight-for-gestational-age proportion optimal birth weight (POBW)-were analysed. Study-specific odds ratios (ORs) 95% confidence intervals (CIs) were estimated using multivariable...
Exceptionally high incidence rates of thyroid cancer have been reported for Melanesian women in New Caledonia (South Pacific). To investigate the occurrence that country and to clarify role goiter hormonal factors disease women, a countrywide population-based case-control study was conducted 1993-1999. The included 293 cases, identified through pathology registers whose verified histologically, 354 population controls. Thyroid associated with goiter, age at menarche, irregular menstruation,...
Background: The association between acute childhood leukaemia and residing next to petrol stations automotive repair garages was analysed in a national registry-based case–control study carried out France 2003–2004. Methods: Population controls were frequency matched with cases on age gender. Data collected by standardised telephone interview the mothers. latter asked report proximity of their homes stations, other businesses from conception index child diagnosis (for cases) or controls)....
Traffic is a source of environmental exposures, including benzene, which may be related to childhood leukemia.A national registry-based case-control study [ESCALE (Etude Sur les Cancers et Leucémies de l'Enfant, Study on Environmental and Genetic Risk Factors Childhood Leukemia)] carried out in France was used assess the effect exposure road traffic exhaust fumes risk leukemia.Over period, 2003-2004, 763 cases 1,681 controls < 15 years old were included, frequency matched with age sex. The...
Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure infectious agents, normal delivery, and animals in life) have been suggested decrease risk childhood acute lymphoblastic leukaemia (ALL).The national registry-based case-control study, ESTELLE, was carried out France 2010-2011. Population controls were frequency matched with cases on age gender. The participation rates 93% 86% controls. Data obtained from structured telephone questionnaires...
Abstract Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little known about BCP-ALL predisposition. In this study, in 2,187 cases European ancestry and 5,543 controls, we discover replicate a locus indexed by rs77728904 at 9p21.3 associated with susceptibility ( P combined =3.32 × 10 −15 , OR=1.72) independent from rs3731217, previously reported ALL-associated variant region. Of correlated SNPs tagged locus, only rs662463...
Objectives The impact of chronic occupational exposures to irritants on asthma remains discussed. We studied the associations between and asthma, with specific interest for exposure irritants, including disinfectants cleaning products (DCPs) solvents. Methods Cross-sectional analyses included 115 540 adults (55% women, mean age 43 years, 10% current asthma) working at inclusion in French population-based CONSTANCES cohort (2012–2020). Current was defined by ever symptoms, medication or...
In an Italian population of 275 unrelated men affected by adult-onset sporadic progressive cerebellar ataxia, the authors found six patients carrying <i>FMR1</i> gene premutation. Age at onset (range, 53 to 69 years) and clinical-neuropathologic findings were consistent with fragile-X tremor ataxia syndrome (FXTAS), although was not as common previously described. <i>FXTAS</i> accounted for 4.2% cases diagnosed >50 years, suggesting that it is a frequent genetic cause late-onset ataxia.