Yves Bertrand
A5106479024- VLSI and Analog Circuit Testing
- Integrated Circuits and Semiconductor Failure Analysis
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Analog and Mixed-Signal Circuit Design
- Parvovirus B19 Infection Studies
- Childhood Cancer Survivors' Quality of Life
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Sensor Technology and Measurement Systems
- Cytomegalovirus and herpesvirus research
- Advanced MEMS and NEMS Technologies
- Erythrocyte Function and Pathophysiology
- Low-power high-performance VLSI design
- Blood groups and transfusion
- Advanced Electrical Measurement Techniques
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Advancements in PLL and VCO Technologies
- Fungal Infections and Studies
- Neuroscience and Neural Engineering
- Digital Image Processing Techniques
- Advancements in Semiconductor Devices and Circuit Design
Institut d’Hématologie et d’Oncologie Pédiatrique
2015-2024
Hospices Civils de Lyon
2015-2024
Université Claude Bernard Lyon 1
2015-2024
Centre de Recherche en Cancérologie de Lyon
2023
HCL Technologies (India)
2004-2021
Centre National de la Recherche Scientifique
1999-2020
Inserm
2004-2020
Centre International de Recherche en Infectiologie
2020
École Normale Supérieure de Lyon
2020
Hôpital Debrousse
2001-2014
The aim of this study was to (1) analyze blood viscosity, red cell (RBC) deformability, and aggregation in hospitalized patients with Coronavirus disease 19 (COVID-19); (2) test the associations between impaired rheology coagulation; (3) several indicators clinical severity. A total 172 COVID-19, COVID-unit Internal Medicine Department (Lyon, France) participated January May 2021. Clinical parameters were collected for each patient. Routine hematological/biochemical parameters, RBC...
This study investigated the role of factors considered related to early stimulation immune system in etiology childhood acute leukemia. The national registry-based case-control ESCALE was carried out France 2003–2004. Population controls were frequency matched cases on age and gender. Data obtained from structured telephone questionnaires administered mothers. Odds ratios estimated using unconditional regression models adjusted for potential confounders. Included 634 lymphoblastic leukemia...
CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment hematopoietic stem cell transplantation (HSCT).We performed international collaborative study to improve patients' management, aiming individualize risk factors determine optimal HSCT characteristics.We retrospectively collected data on 130 patients...
From circuit measurement, it has been demonstrated that actual bridging faults have an intrinsic resistance mainly in the range from 0 /spl Omega/ to 500 Omega/. This paper first analyses consequences of this on electrical and logic behavior faults. Second, is classical models such as voting model which consider negligible, do not accurately realistically represent fault. Third, a new parametric fault proposed allowing faulty according known priori. Finally, simulation algorithm described...
Abstract From March 1984 through November 1985, 24 children and adults with aplastic crises were admitted in several Parisian hospitals. Twelve patients had known hemolytic anemia. Aplastic crisis revealed anemia the remaining patients. The detection of human parvovirus antigen was performed by counter‐immunoelectrophoresis, specific IgM antibodies detected IgM‐antibody‐capture‐radioimmunoassy, order to establish incidence infection genesis crisis. Twenty‐one acute parvovirus. In three...
Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, organogenesis in the developing nervous system, but have been recently evidenced also playing a role immune system. Here we describe expression semaphorin 3F (SEMA3F) its receptor neuropilin-2 (NRP2) human T cell precursors. NRP2 SEMA3F expressed thymus, both lymphoid non-lymphoid compartments. repulsive effect on thymocyte migration inhibited CXCL12- sphingosine-1-phosphate (S1P)-induced by inhibiting...
The CXCL12/CXCR4 signaling exerts a dominant role in promoting hematopoietic stem and progenitor cell (HSPC) retention quiescence bone marrow. Gain-of-function CXCR4 mutations that affect homologous desensitization of the receptor have been reported WHIM Syndrome (WS), rare immunodeficiency characterized by lymphopenia. mechanisms underpinning this remain obscure. Using mouse model with naturally occurring WS-linked gain-of-function Cxcr4 mutation, we explored possibility lymphopenia WS...