Monica Bhatia
A5102914111- Immune Cell Function and Interaction
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Iron Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Adrenal Hormones and Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Kawasaki Disease and Coronary Complications
- Otitis Media and Relapsing Polychondritis
- Transplantation: Methods and Outcomes
- Invertebrate Immune Response Mechanisms
- Blood disorders and treatments
- Insect Utilization and Effects
- Hematopoietic Stem Cell Transplantation
- Neonatal and Maternal Infections
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Cell Adhesion Molecules Research
- Parasites and Host Interactions
- Respiratory viral infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cystic Fibrosis Research Advances
- Cytomegalovirus and herpesvirus research
Columbia University
2019-2025
Columbia University Irving Medical Center
2015-2024
Morgan Stanley Children's Hospital
2020
Leukemia Research Foundation
2011
New York Blood Center
2011
Washington University Medical Center
2004
George Washington University
2004
<h3>Background</h3> Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by <i>FOXP3</i> mutations. Because it rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) immunosuppression (IS), have not been thoroughly examined. <h3>Objective</h3> This analysis sought evaluate onset, progression, long-term outcome of 2 main treatments in IPEX survivors....
CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment hematopoietic stem cell transplantation (HSCT).We performed international collaborative study to improve patients' management, aiming individualize risk factors determine optimal HSCT characteristics.We retrospectively collected data on 130 patients...
Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function. Patients with PIRD develop clinical manifestations associated diminished and exaggerated responses. Management these patients is complicated; oftentimes immunosuppressive therapies insufficient, may require hematopoietic transplant (HCT) for treatment. Analysis HCT data have previously focused on a single defect. This...
An increasing number of allogeneic transplant and autologous gene modification therapies seek to eradicate sickle hemoglobin the consequent hemolysis, vasculopathy, functional compromise, morbidity mortality. As these modalities are used in parallel, it is important be able define spectrum stability correction, long-term effects, pros cons each modality. A comparison between interventions that will sought by providers patients undergoing intervention require uniform assessments evaluate...
Studies of the monogenic autoimmune disease immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX) have elucidated essential function transcription factor FOXP3 and thymic-derived regulatory T cells (T regs ) in controlling peripheral tolerance. However, presence source autoreactive IPEX remain undetermined. Here, we investigated how deficiency affects cell receptor (TCR) repertoire reg stability vivo compared abnormalities patients with those...
Parasitic helminths induce chronic infections in their hosts although, with most human helminthiases, protective immunity gradually develops age or exposure of the host. One exception is infection hookworm, Necator americanus, where virtually no protection ensues over time. Such observations suggest these parasites have developed unique mechanisms to evade host immunity, leading us investigate role excretory/secretory (ES) products adult N. americanus manipulating immune responses....
Abstract The monogenic autoimmune disease Immunedysregulation polyendocrynopathy entheropathy X-linked syndrome (IPEX) has elucidated the essential function of transcription factor FOXP3 and thymic-derived regulatory T (Treg) cells in controlling autoimmunity. However, presence autoreactive IPEX remains undetermined, thus representing a crucial gap understanding origin autoimmunity deficient immune system. Combining epigenetic analysis as lineage marker Treg identity TCR sequencing to assess...
Abstract Objective Sickle cell disease (SCD) is associated with significant morbidity and mortality. Hematopoietic stem transplantation (HCT) can improve health-related quality of life (HRQOL) but may be physically emotionally challenging. Thus, the aim this study was to understand experience HCT from perspective youth young adults (YYAs) post-HCT for SCD their parents. Methods YYAs were recruited an urban hospital. Sociodemographic HCT-specific information analyzed all enrolled. and/or...