A5008223622- Growth Hormone and Insulin-like Growth Factors
- Axon Guidance and Neuronal Signaling
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Galectins and Cancer Biology
- Biological Stains and Phytochemicals
- Adrenal Hormones and Disorders
- Natural product bioactivities and synthesis
- Wound Healing and Treatments
- Lymphatic System and Diseases
- Hematopoietic Stem Cell Transplantation
- Trypanosoma species research and implications
- Cellular Mechanics and Interactions
- Essential Oils and Antimicrobial Activity
- Phagocytosis and Immune Regulation
- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- Morinda citrifolia extract uses
- Medicinal Plant Extracts Effects
Universidade Federal de Alagoas
2014-2025
Fundação Oswaldo Cruz
2003-2025
Délégation Paris 5
2009
Centre National de la Recherche Scientifique
2009
Université Paris Cité
2009
Inserm
2005
Hôpital Necker-Enfants Malades
2005
Universidade Federal de São Paulo
1996
It is largely established that molecules first discovered in the nervous system are also found immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and involved peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 human thymus. expressed both cortex medulla of thymic lobules, being distinct CD4/CD8-defined thymocyte subsets. epithelial cells (TEC) situ vitro , recruited at site TEC–thymocyte...
Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with oxidative stress participating in its progression. This study aimed to evaluate profile young and old mice MetS, effects apocynin tempol on glycemic lipid parameters. Young C57BL/6 high fat diet- (HFD-) induced MetS received 50 mg·kg(-1)/day their drinking water for 10 weeks. After HFD, group showed elevated fasting glucose, worsened plasma, steatosis, hepatic peroxidation....
Nanoparticles have extremely wide applications in the medical and biological fields. They are being used biosensors, local drug delivery, diagnostics, therapy. However, potential effects of nanoparticles on target cell tissue function, apart from cytotoxicity, not completely understood. Thus, aim this study was to investigate vitro silver (AgNPs) gold (AuNPs) human fibroblasts with respect their interaction extracellular matrix migration. Immunofluorescence analysis revealed that treatment...
Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, organogenesis in the developing nervous system, but have been recently evidenced also playing a role immune system. Here we describe expression semaphorin 3F (SEMA3F) its receptor neuropilin-2 (NRP2) human T cell precursors. NRP2 SEMA3F expressed thymus, both lymphoid non-lymphoid compartments. repulsive effect on thymocyte migration inhibited CXCL12- sphingosine-1-phosphate (S1P)-induced by inhibiting...
The decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In present study, wound healing activity aqueous extract bark B. virgilioides, called AEBv, was evaluated by rate contraction period epithelization at different days post-wound using excisional model. On day 9, AEBv-treated animals exhibited significative reduction area when compared with controls. infected S. aureus, AEBv significantly...
Previous evidence indicates that GH modulates thymic cell migration. In this study we approached issue in vivo, studying thymocyte migration transgenic animals and normal mice treated intrathymically with GH. Extracellular matrix chemokines are involved respect, adhesion to laminin was higher GH-treated than controls, the numbers of migrating cells laminin-coated Transwells GH-transgenic GH-injected mice. Additionally, CXC chemokine ligand 12 (CXCL12)-driven GH-Tg compared controls....
Abstract We previously described a fibronectin/VLA-5-dependent impairment of NOD thymocyte migration, correlated with partial arrest within thymic perivascular spaces. Yet, thymocytes still emigrate, suggesting the involvement other cell migration-related alterations. In this context, aim work was to study role extracellular matrix ligands, alone or in combination chemokine CXCL12, migration. Intrathymic contents fibronectin, and laminin were evaluated by immunohistochemistry while...
ABSTRACT Intrathymic T cell differentiation takes place within the thymic lobules and depends on interactions between developing thymocytes cells of microenvironment. Along with differentiation, migrate in an oriented progression, which is tightly regulated by a number interactions, including one mediated chemokine CXCL12. It has been shown recently that SEMA-3A, soluble member semaphorin family, also involved this human thymocyte migration can have chemorepulsive de-adhesive role. Herein,...
Uvaol, a triterpene present in olives and virgin olive oil, has been shown to possess anti-inflammatory properties antioxidant effects. However, until now, no studies have demonstrated its potential effects on allergic inflammation. The aim of this study was evaluate the uvaol mouse model allergy characterized by eosinophil-dominant inflammation actively sensitized mice. effect analyzed two murine models (pleurisy asthma). In these models, Swiss mice were challenged with ovalbumin (OVA)....
This study aims to evaluate the effects of diets deficient in choline and/or cystine on hepatocellular injury animal models (young male Wistar rats, aged 21 days), by monitoring some oxidative stress biomarkers and expression RAGE, TNF- α , IL-1 β . The animals were divided into 6 groups (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>10</mml:mn></mml:math>) submitted different over 30 days: AIN-93 diet (standard, St), (CD) (CCD)...
The generation of new blood vessels is a complex process mediated by variety growth factors, and the hormone (GH) has been shown to act as proangiogenic factor. In fact, human GH deficiency or excess are associated with endothelial dysfunction. Moreover, mouse models have revealed action in both tissue repair microvascular circulation normal tissues. this study, we investigated vitro effects on cells. Using murine endothelioma cell line (tEnd.1), demonstrated that mitogenic effect. also...
Growth hormone (GH) has been shown to stimulate T cell development. However, its mechanisms of action on the peripheral pool remain unknown. To address this question, intrathymic injection GH in combination with fluorescein isothiocyanate (FITC) was used assess effects trafficking from thymus periphery. promoted a significant increase percentage and differential distribution thymic CD4+CD8–FITC+ cells secondary lymphoid organs. A significantly higher observed lymph nodes, while relative...
Previous evidence indicated that growth hormone (GH) modulates cell migration in the thymus, and extracellular matrix chemokines are involved. Herein, we studied of peripheral lymphocytes derived from spleen lymph nodes GH-transgenic (GH-Tg) mice. We initially found relative numbers (normalized per gram body weight) spleens GH-Tg were higher at all ages tested (2-3, 7 12 months), as compared to wild type age-matched controls. Functionally, lymphocyte triggered by laminin or fibronectin was...