A5026908641- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cancer Risks and Factors
- Carcinogens and Genotoxicity Assessment
- Peripheral Neuropathies and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Bowel Disease
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Biosimilars and Bioanalytical Methods
- Noise Effects and Management
- Folate and B Vitamins Research
- Pharmaceutical studies and practices
- Hemophilia Treatment and Research
- Healthcare Systems and Practices
- Rheumatoid Arthritis Research and Therapies
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Asthma and respiratory diseases
- Hereditary Neurological Disorders
- Pediatric health and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Ginkgo biloba and Cashew Applications
Pfizer (France)
2020-2025
Pfizer (United States)
2021-2024
Centre Hospitalier Universitaire de Saint-Étienne
2024
l'Assurance Maladie
2016-2020
Centre de recherche en Epidémiologie et Santé des Populations
2010-2020
Inserm
2009-2020
Assistance Publique – Hôpitaux de Paris
2005-2020
Université Paris-Sud
2006-2020
Université de Versailles Saint-Quentin-en-Yvelines
2020
Université Paris-Saclay
2018-2020
Purpose Significant regression of radiation (RT) -induced fibrosis (RIF) has been achieved after treatment combining pentoxifylline (PTX) and alpha-tocopherol (vitE). In this study, we focus on the maximum response, how long it takes to achieve changes discontinuation. Patients Methods Measurable superficial RIF was assessed in patients treated by RT for breast cancer a long-treatment (24 48 months) PTX-vitE (LPE) group 37 (47 RIFs) short-treatment (6 12 (SPE) seven (eight RIFs). Between...
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control in Childhood Leukemia International Consortium. Exposure were harmonized into compatible formats. Pooled analyses undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with...
The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation the immune system, that is, day-care center attendance, birth order, maternally reported common infections in infancy, breastfeeding, were investigated by using data from 11 case-control studies participating Childhood Leukemia International Consortium (enrollment period: 1980–2010). sample included 7,399 ALL cases 11,181 controls aged 2–14 years. collected questionnaires...
Objective To assess the relation between invasive dental procedures and infective endocarditis associated with oral streptococci among people prosthetic heart valves.Design Nationwide population based cohort a case crossover study.Setting French national health insurance administrative data linked hospital discharge database.Participants All adults aged more than 18 years, living in France, medical procedure codes for positioning or replacement of valves July 2008 2014.Main outcome measures...
Maternal occupational pesticide exposure during pregnancy and/or paternal around conception have been suggested to increase risk of leukemia in the offspring. With a view providing insight this area we pooled individual level data from 13 case‐control studies participating Childhood Leukemia International Consortium (CLIC). Occupational were harmonized compatible format. Pooled analyses undertaken using unconditional logistic regression. Using mothers 8,236 cases, and 14,850 controls,...
CT-P13 is a biosimilar of the reference product (RP) infliximab, with demonstrated efficacy and safety for some inflammatory arthritides. It was approved treatment Crohn disease (CD) on that basis, without specific studies examining its effects in CD.To compare effectiveness RP infliximab-naive patients CD.Comparative equivalence cohort study.Système National des Données de Santé (SNDS), French nationwide health administrative database (1 March 2015 to 30 June 2017).5050 CD who were older...
This study investigated the role of factors considered related to early stimulation immune system in etiology childhood acute leukemia. The national registry-based case-control ESCALE was carried out France 2003–2004. Population controls were frequency matched cases on age and gender. Data obtained from structured telephone questionnaires administered mothers. Odds ratios estimated using unconditional regression models adjusted for potential confounders. Included 634 lymphoblastic leukemia...
The aim of this work is to study the risk childhood acute leukemia (AL) around French nuclear power plants (NPPs). nationwide Geocap case-control included 2,753 cases diagnosed in mainland France over 2002-2007 and 30,000 contemporaneous population controls. last addresses were geocoded located 19 NPPs. used distance NPPs a dose-based geographic zoning (DBGZ), based on estimated dose bone marrow related NPP gaseous discharges. An odds ratio (OR) 1.9 [1.0-3.3], 14 cases, was evidenced for...
High-voltage overhead power lines (HVOLs) are a source of extremely low-frequency magnetic fields (ELF-MFs), which classified as possible risk factors for childhood acute leukaemia (AL). The study was carried out to test the hypothesis an increased AL incidence in children living close HVOL 225–400 kV (VHV-HVOL) and 63–150 (HV-HVOL). nationwide Geocap included all 2779 cases diagnosed France over 2002–2007 30 000 contemporaneous population controls. addresses at time inclusion were geocoded...
Maternal prenatal supplementation with folic acid and other vitamins has been inconsistently associated a reduced risk of childhood acute lymphoblastic leukemia (ALL). Little is known regarding the association myeloid (AML), rarer subtype.We obtained original data on use from 12 case-control studies participating in Childhood Leukemia International Consortium (enrollment period: 1980-2012), including 6,963 cases ALL, 585 AML, 11,635 controls. Logistic regression was used to estimate pooled...
<h3>Importance</h3> An aging population is increasing the need for intensive care unit (ICU) beds. The benefit of ICU admission elderly patients remains a subject debate; however, long-term outcomes across all adult age strata are unknown. <h3>Objective</h3> To describe short-term and mortality (up to 3 years after discharge) in admitted French ICUs. <h3>Design, Setting, Participants</h3> Using data extracted from national health system database, this cohort study determined in-hospital at...
Positive associations have been reported between the measures of accelerated fetal growth and risk childhood acute lymphoblastic leukemia (ALL). We investigated this association by pooling individual-level data from 12 case-control studies participating in Childhood Leukemia International Consortium. Two growth-weight-for-gestational-age proportion optimal birth weight (POBW)-were analysed. Study-specific odds ratios (ORs) 95% confidence intervals (CIs) were estimated using multivariable...
To assess the association between Guillain-Barré syndrome (GBS) and recent surgery based on French nationwide data.Data were extracted from health administrative databases (SNIIRAM/PMSI). All patients hospitalized for GBS 2009 2014 identified by ICD-10 code G61.0 as main diagnosis. Patients previously in 2006, 2007, 2008 excluded. Surgical procedures hospital database. Hospitalizations with no infection diagnosis entered during stay also identified. The a surgical procedure was estimated...
We investigated the role of household exposure to pesticides in etiology childhood hematopoietic malignancies.The national registry-based case-control study ESCALE (Etude sur les cancers de l'enfant) was carried out France over period 2003-2004. Population controls were frequency matched with cases on age and sex. Maternal use during pregnancy paternal or reported by mothers a structured telephone questionnaire. Insecticides (used at home, pets, for garden crops), herbicides, fungicides...
Background: The association between acute childhood leukaemia and residing next to petrol stations automotive repair garages was analysed in a national registry-based case–control study carried out France 2003–2004. Methods: Population controls were frequency matched with cases on age gender. Data collected by standardised telephone interview the mothers. latter asked report proximity of their homes stations, other businesses from conception index child diagnosis (for cases) or controls)....
Long-term clinical effectiveness of biologics in psoriasis is needed.We aimed to assess the long-term persistence used treat a real-life setting.All adults with having been registered French National Health Insurance database (SNIIRAM) between 2008 and 2016 were eligible for inclusion. Psoriasis was defined as fulfilment at least two prescriptions topical formulations vitamin D derivative within 2-year period. The study population comprised biologic-naïve patients, i.e. those first...
Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure infectious agents, normal delivery, and animals in life) have been suggested decrease risk childhood acute lymphoblastic leukaemia (ALL).The national registry-based case-control study, ESTELLE, was carried out France 2010-2011. Population controls were frequency matched with cases on age gender. The participation rates 93% 86% controls. Data obtained from structured telephone questionnaires...