A5080730102- Blood properties and coagulation
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Hemostasis and retained surgical items
- COVID-19 and healthcare impacts
- Epilepsy research and treatment
- Lipid metabolism and disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Advanced MRI Techniques and Applications
- Dermatological and COVID-19 studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
Université Claude Bernard Lyon 1
2024-2025
Hospices Civils de Lyon
2021-2025
Hôpital Louis Pradel
2024
The aim of this study was to (1) analyze blood viscosity, red cell (RBC) deformability, and aggregation in hospitalized patients with Coronavirus disease 19 (COVID-19); (2) test the associations between impaired rheology coagulation; (3) several indicators clinical severity. A total 172 COVID-19, COVID-unit Internal Medicine Department (Lyon, France) participated January May 2021. Clinical parameters were collected for each patient. Routine hematological/biochemical parameters, RBC...
Abstract Introduction Early prophylaxis is the gold standard of care for severe haemophilia. The development subcutaneous Factor VIII (FVIII) mimetics, such as emicizumab, has significantly reduced disease burden and improved protection against bleeding episodes. Despite its benefits, emicizumab does not fully normalize haemostasis, requiring additional FVIII treatment surgical procedures management breakthrough bleeding. In these cases, extended or ultra‐extended half‐life products are most...
Acute normoxic exercise impacts the rheological properties of red blood cells (RBC) and their senescence state; however, there is a lack data on effects performed in hypoxia RBC properties. This crossover study compared acute vs. normoxia rheology, senescence, coagulation during exercise. Nine trained male cyclists completed both session (FiO2 = 21%) 15.3% ≈ 2500 m). The two sessions were randomly performed, separated by one week, consisted an incremental maximal followed 20 min at first...
Despite systematic thromboprophylaxis, 30% of the COVID-19 patients in intensive care units develop thrombosis. This occurrence is associated with a hypofibrinolytic state measured by thromboelastometry when adding tissue plasminogen activator (tPA) to citrated whole blood for further run EXTEM (ROTEM).
Summary Leg Ulcer (LU) pathophysiology is still not well understood in sickle cell anaemia (SCA). We hypothesised that SCA patients with LU would be characterised by lower microvascular reactivity. The aim of the present study was to compare microcirculatory function (transcutaneous oxygen pressure (TcPO 2 ) on foot and laser Doppler flowmetry arm) several blood biological parameters between nine active (LU+) 56 no positive history (LU−). also tested effects plasma from LU+ LU− endothelial...
Glanzmann’s thrombasthenia (GT) is a rare autosomal recessive disorder of platelet function. The frequent occurrence alloimmunization due to repeated transfusions the major complication disease. Achieving hemostasis in these patients with anti-GPIIb-IIIa antibodies during surgical procedures significant challenge high risk bleeding. Recombinant activated factor VII (rFVIIa) an effective agent for achieving alloimmunized patients. key clinical question was determine whether abdominal aortic...