A5035002099- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- IgG4-Related and Inflammatory Diseases
- Polyomavirus and related diseases
- Sarcoidosis and Beryllium Toxicity Research
- Dermatologic Treatments and Research
- Cerebral Venous Sinus Thrombosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Lymphoblastic Leukemia research
- Retinal and Optic Conditions
- Long-Term Effects of COVID-19
- Ocular Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Trigeminal Neuralgia and Treatments
- Multiple Myeloma Research and Treatments
- Cerebrospinal fluid and hydrocephalus
- Parasitic infections in humans and animals
- Acne and Rosacea Treatments and Effects
- Research on Leishmaniasis Studies
- Maritime Ports and Logistics
- Kawasaki Disease and Coronary Complications
- Vasculitis and related conditions
- Intracerebral and Subarachnoid Hemorrhage Research
Fondation Ophtalmologique Adolphe de Rothschild
2021-2025
Fondation de Rothschild
2020-2024
Foundation Fighting Blindness
2023
Hôpital Lariboisière
2018-2022
Pitié-Salpêtrière Hospital
2016-2021
Sorbonne Université
2016-2021
Université Paris-Saclay
2021
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2021
CEA Paris-Saclay
2021
Assistance Publique – Hôpitaux de Paris
2016-2021
<h3>Objectives</h3> To explore in vivo innate immune cell activation as a function of the distance from ventricular CSF patients with multiple sclerosis (MS) using [<sup>18</sup>F]-DPA714 PET and to investigate its relationship periventricular microstructural damage, evaluated by magnetization transfer ratio (MTR), trajectories disability worsening. <h3>Methods</h3> Thirty-seven MS 19 healthy controls underwent MRI TSPO dynamic PET, which individual maps voxels characterized (DPA+) were...
Possible outcomes of acne lesions are atrophic scars, which may cause serious psychological distress. Current treatments for postacne scarring often require invasive procedures. Pathophysiological studies on have only investigated the first week papule life. To study pathophysiology scar formation to identify molecular and cellular pathways that can lead new therapies prevention scarring. Large‐scale gene expression profiling immunohistochemistry analysis were performed uninvolved skin...
ABSTRACT Introduction Patients diagnosed with optic neuritis (ON) who did not fulfil the diagnostic criteria for multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMO‐SD), tested negative myelin oligodendrocyte glycoprotein immunoglobulin G and which a systemic disease has been excluded are classified as having idiopathic ON (IDON). Methods This was monocentric retrospective observational study. Inclusion were follows: patients IDON, absence of an alternative diagnosis during...
The kappa free light chains index (κ-index) is increasing in importance as a fast, easy, cost-effective, and quantitative biomarker multiple sclerosis (MS), which can replace cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) detection. In previous studies, controls often included mixed patients with several inflammatory central nervous system disorders. aim of the present study was to assess κ-index serum aquaporin-4 (AQP4)-IgG or myelin-oligodendrocyte-glycoprotein (MOG)-IgG.We...
This study was undertaken to determine the role of optical coherence tomography (OCT) in predicting final visual and structural outcome, evaluate correlation between functional eye outcome retinal changes, patients with a first episode optic neuritis (ON).In this prospective study, consecutive adult acute ON underwent ophthalmological evaluation at baseline 1 12 months, including OCT measurements peripapillary nerve fiber layer (pRNFL), macular ganglion cell inner plexiform layer, nuclear...
Background and objectives Neuromyelitis optica spectrum disorders (NMOSDs) are a group of diseases mainly characterised by recurrent optic neuritis and/or myelitis. Most cases associated with pathogenic antibody against aquaporin-4 (AQP4-Ab), while some patients display autoantibodies targeting the myelin oligodendrocyte glycoprotein (myelin antibodies (MOG-Abs)). Anti-Argonaute (Ago-Abs) were first described in rheumatological conditions recently reported as potential biomarker neurological...
Abstract Background/purpose Following intradermal injection, hyaluronic acid (HA)‐based fillers tend to spread within the reticular dermis and distribute between dermal fibers. This biointegration is commonly measured qualitatively using histological methods. We developed a “toolbox” consisting of visual scoring semi‐automatic image analysis method internal algorithm quantitate Restylane® in sections. Methods Restylane ® was injected intradermally abdominal skin 10 healthy human subjects...
<h3>ABSTRACT</h3> Acute meningitis can be the first manifestation of an underlying systemic inflammatory disorder (SID). In current study, we aimed to identify clinical indicators for SIDs in patients admitted acute aseptic meningitis. All hospitalised over a 4-year period department internal medicine were included retrospectively. Patients with neoplastic excluded. Extraneurological signs recorded using systematic panel. Systemic diagnosis was made according international criteria....
Fingolimod is a widely used treatment for highly active relapsing-remitting multiple sclerosis.To describe the case of 27-year-old patient treated more than 2 years by Fingolimod, who presented hemiplegia and speech disturbances associated with extensive white matter lesions on brain magnetic resonance imaging (MRI).Case study.Although initial presentation questioned possibility progressive multifocal leukoencephalopathy, final diagnosis was sclerosis (MS) relapse. Appropriate resulted in...
MR imaging is the technique of choice for patients presenting with acute loss visual acuity no obvious ophthalmologic cause. The goal our study was to compare orbits contrast-enhanced 2D coronal T1WI a whole-brain 3D (WBCE-3D) TSE at 3T detection optic nerve enhancement.