Marianne Gazzano
A5090249273- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- vaccines and immunoinformatics approaches
- Immune cells in cancer
- Hepatitis C virus research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Hemodynamic Monitoring and Therapy
- Cancer Research and Treatments
- Pituitary Gland Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Clostridium difficile and Clostridium perfringens research
- Infection Control and Ventilation
- Fungal Infections and Studies
- COVID-19 epidemiological studies
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
Pitié-Salpêtrière Hospital
2022-2024
Sorbonne Université
2022-2024
Assistance Publique – Hôpitaux de Paris
2022-2023
Inserm
2021-2022
Centre d'Immunologie et des Maladies Infectieuses
2022
Institut Gustave Roussy
2021-2022
La Ligue Contre le Cancer
2022
University of Milan
1997
Abstract Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and blood samples, we found that follicular helper CD4+ T cells (TFH) among best therapeutic targets pembrolizumab correlating progression-free survival. TFH were associated tumoral CD8 PD-L1 expression at baseline induction tertiary lymphoid structures after pembrolizumab. Blood central memory accumulated in tumors...
Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case diabetic patient with refractory IFD following SARSCoV-2 infection treated by ICI interferon-gamma associated antifungal treatment.
The kappa free light chains index (κ-index) is increasing in importance as a fast, easy, cost-effective, and quantitative biomarker multiple sclerosis (MS), which can replace cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) detection. In previous studies, controls often included mixed patients with several inflammatory central nervous system disorders. aim of the present study was to assess κ-index serum aquaporin-4 (AQP4)-IgG or myelin-oligodendrocyte-glycoprotein (MOG)-IgG.We...
Abstract Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine release was...
Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether IgA-deficiency is associated gut fungal dysbiosis remains unknown. Our goal was to study the of ecology. The Fungi-Flow method used characterize fecal, systemic, and maternal IgA, IgM, IgG responses against 14 representative strains (yeast/spores or hyphae forms) in healthy donors (HDs) (n = 34, 31, 20, respectively) also compare opsonization by...
535 Background: Immune checkpoint inhibitors (ICIs), such as anti-PD-1/PD-L1 antibodies, have emerged a successful immunotherapeutic strategy for advanced and metastatic urothelial cancer (UC). Therapeutic blockade of PD-1 or PD-L1 with monoclonal antibodies leads to durable tumor regressions in up 25% muscle invasive UC (MIBC). Neoadjuvant use ICI also showed remarkable efficacy represents unique opportunity study immunodynamics during decipher functional predictors response resistance....
Immune checkpoint inhibitors (ICI) widely improved the treatment of solid and hematologic malignancies. Yet, a remarkable proportion patients receiving ICI develop immune related adverse events (irAEs) which are difficult to define as treatment-related. This underlines need biomarker guide irAE diagnosis. We developed novel flow cytometry assay combining measurement anti-PD-1 (programmed cell death protein-1) occupancy evaluation remaining PD-1 receptor availability with anti-IgG4 PE BV421....
<div>Abstract<p>Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine...
<div>Abstract<p>Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and blood samples, we found that follicular helper CD4<sup>+</sup> T cells (T<sub>FH</sub>) among best therapeutic targets pembrolizumab correlating progression-free survival. T<sub>FH</sub> were associated tumoral CD8 PD-L1 expression at baseline induction...
<div>Abstract<p>Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and blood samples, we found that follicular helper CD4<sup>+</sup> T cells (T<sub>FH</sub>) among best therapeutic targets pembrolizumab correlating progression-free survival. T<sub>FH</sub> were associated tumoral CD8 PD-L1 expression at baseline induction...
Supplementary Figure from <i>Escherichia coli</i>–Specific CXCL13-Producing T<sub>FH</sub> Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer
Supplementary Figure from <i>Escherichia coli</i>–Specific CXCL13-Producing T<sub>FH</sub> Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer
<div>Abstract<p>Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine...
Supplementary Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer Healthy Individuals
Supplementary Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer Healthy Individuals
Supplementary Figure from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer Healthy Individuals
Supplementary Figure from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer Healthy Individuals
Abstract Optimal vaccination and immunotherapy against coronavirus disease COVID-19 relies on the in-depth comprehension of immune responses determining individual susceptibility to be infected by SARS-CoV-2 develop severe disease. We characterized polarity specificity circulating SARS-CoV-2-specific T cell whole virus lysates or 186 unique peptides derived from SARS-CoV-1 ORFeome 296 cancer-bearing 86 cancer-free individuals who were either pre-COVID-19 era (67 individuals) contemporary...