A5114858701- Pancreatic function and diabetes
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Respiratory Support and Mechanisms
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Developmental Biology and Gene Regulation
- Lymphatic System and Diseases
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- Biomarkers in Disease Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Lysosomal Storage Disorders Research
- Apelin-related biomedical research
- Axon Guidance and Neuronal Signaling
- Environmental Science and Water Management
University of Tübingen
2017-2025
Hôpitaux Universitaires de Strasbourg
2024
Nelson Mandela University
2024
University of Liège
2015-2024
Université de Strasbourg
2021-2024
Inserm
2021-2024
University Children's Hospital Tübingen
2022-2023
Universitätsklinikum Tübingen
2023
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021
Institut Gustave Roussy
1988-2021
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators this condition have remained elusive. We used a multi-omics analysis combined with artificial intelligence in young patient cohort where comorbidities were excluded at the onset. included 47 “critical” (in intensive care unit under mechanical ventilation) 25 “non-critical” non-critical ward) patients COVID-19 22 healthy individuals....
Contrast medium is frequently associated with allergic reactions and kidney dysfunction. However, contrast media can induce hemolytic anemia a broad spectrum of manifestations. We report 38-year-old patient very severe immune after the application iomeprol due to CT thorax/abdomen. In this case report, we illustrate diagnostics treatment life-threatening induced by that was successfully treated eculizumab.
Background and purpose The presentation of Parkinson's disease patients with mutations in the LRRK 2 gene ( PD ) is highly variable, suggesting a strong influence modifying factors. In this context, inflammation potential candidate inducing clinical subtypes. Methods An extensive battery peripheral inflammatory markers was measured human serum multicentre cohort 142 from MJFF Consortium, stratified by three different subtypes as recently proposed for idiopathic disease: diffuse/malignant,...
Defining the transcriptome and genetic pathways of pancreatic cells is great interest for elucidating molecular attributes pancreas disorders such as diabetes cancer. As function different cell types has been maintained during vertebrate evolution, comparison their transcriptomes across distant species a means to pinpoint genes under strong evolutionary constraints due crucial function, which have therefore preserved selective expression in these types. In this study, RNA-sequencing was...
Significance Nonresolving inflammation, a hallmark of sepsis and/or multi-organ failure, still poses challenge in medicine. The mortality rate is enormous, and so far no adequate curative therapy available. Here we identify previously unrecognized role the neuronal guidance protein semaphorin 7A transition to resolution processes severe systematic inflammation such as sepsis.
Introduction Previous studies demonstrated that the implementation of Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity AKI after surgery. However, effects care bundle broader population undergoing surgery require confirmation. Methods analysis The BigpAK-2 trial is an international, randomised, controlled, multicentre trial. aims to enrol...
Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, Matrix Metalloproteinase-9 (MMP9), matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson's disease with (PDD) without dementia (PDND) (DLB). GDF15 has prominent role in development, cell proliferation, differentiation, repair, whereas MMP9 degrades, as proteolytic...
Abstract Background Acute respiratory distress syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role this are unavailable. Therefore, we investigated whether inhaled would affect oxygenation survival patients suffering from ARDS. Methods We performed prospective randomized controlled single-blind multicenter trial across Germany. The was conducted March 2019 with...
Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This is fundamentally dependent on the activation of neutrophils innate immune response. Recent work has shown that semaphorin 7A (Sema7A) holds significant impact platelet function, yet its role neutrophil function within lung not well understood. study aimed to identify Sema7A pulmonary inflammation In patients with acute respiratory distress syndrome (ARDS), we were able show a correlation between...
Abstract Increasing evidence indicates that rosettes which spontaneously from between human T cells and E might be of physiologic relevance. We show here another cell-surface molecule than CD2 is involved in rosette formation. Four mAb have been obtained reacting with block many species, including autologous cells. They react a molecule, we termed E2, actively synthetized by monocytic Immunoprecipitation revealed major 32-kDa band. Immunoblots band minor 20-kDa This was detected on all...
Background: Blood levels of immune markers have been proposed to discriminate patients with Parkinson's disease (PD) from controls. However, differences between clinical PD subgroups regarding these still need be identified. Objective: To investigate whether phenotypes can predicted by the assessment marker profiles in serum patients. Methods: Phenotypes Tübingen, Germany (n = 145) and Toronto, Canada 90) were defined subtype, onset, severity, progression as well presence cognitive and/or...
ARP/ASCL transcription factors are key determinants of cell fate specification in a wide variety tissues, coordinating the acquisition generic fates and specific subtype identities. How these factors, recognizing highly similar DNA motifs, display activities, is not yet fully understood. To address this issue, we overexpressed different zebrafish ascl1a-/- mutant embryos to determine which ones able rescue intestinal secretory lineage. We found that Ascl1a/b, Atoh1a/b Neurod1 all trigger...
Abstract Background Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timing of initiation vvECMO therapy. We aimed investigate association between number days invasive mechanical ventilation (IMV) prior implantation and mortality. Methods In this retrospective observational study, we included treated at an academic intensive care unit for...
Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to development venous vasculature, both at cellular and molecular levels. Here, we identify a novel role for Sorbs1, founding member SoHo family cytoskeleton adaptor proteins, in vascular zebrafish.
A wide range of human diseases result from haploinsufficiency, where gene expression is decreased as compared to normal conditions. Haploinsufficiency a typical mechanism in autosomal dominant disorders. Rare mutations Sim1 or Mc4r are models haploinsufficiency causing severe early-onset obesity with hyperphagia. Gene therapy by adenovirus vectors has been developed rescue such disorders, expressing the allele place mutant. However, this strategy limited size DNA that can be packaged virus,...
Abstract Rationale Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic. Objectives A total 144 patients with caused by COVID-19 or other origin were recruited a randomized multicenter trial. Methods Clinical data intensive care treatment and up to 180 days study inclusion collected. Changes Sequential Organ Failure Assessment score used quantify severity. Disability was...
This article describes the statistical analysis plan for Biomarker-guided intervention to prevent AKI after major surgery (BigpAK-2) trial.
Abstract Background Intracellular sensing of lipopolysaccharide (LPS) is essential for the immune response against gram-negative bacteria and results in activation caspase-11 pyroptotic cell death with fatal consequences sepsis. We found neuronal guidance receptor plexin C1 (PLXNC1) influences intracellular to LPS. Methods employed a murine model sepsis via cecal ligation binding (CLP), using PLXNC1-/- mice littermate controls, additionally transfected bone-marrow-derived macrophages (BMDMs)...
Inositol 1,4,5-trisphosphate (IP3) receptor type 1 ( ITPR1 ), 2 ITPR2 and 3 ITPR3 ) encode the IP3 (IP3R), a key player in intracellular calcium release. In four unrelated patients, we report that an identical de novo variant—NM_002224.3:c.7570C>T, p.Arg2524Cys—causes, through dominant-negative effect, complex multisystemic disorder with immunodeficiency. This leads to defective homeostasis, mitochondrial malfunction, CD4 + lymphopenia, quasi-absence of naïve CD8 cells, increase memory...
Abstract The etiopathogenesis of severe COVID-19 remains unknown. Indeed given major confounding factors (age and co-morbidities), true drivers this condition have remained elusive. Here, we employ an unprecedented multi-omics analysis, combined with artificial intelligence, in a young patient cohort where co-morbidities been excluded at the onset. established three-tier individuals younger than 50 years without comorbidities. These included 47 “critical” (in ICU under mechanical...
3565 Background: Chemoradiotherapy (CRT) is the current standard of care for patients diagnosed with locally advanced anal squamous cell carcinoma (ASCC), but some will present a local and/or distant relapse during follow-up. We previously reported analytical validity HPV circulating tumor DNA (HPV-ctDNA) detection by droplet digital PCR in HPV-related cancers. The study aimed at monitoring ctDNA levels CRT ASCC. Methods: analyzed prospectively collected samples from HPV16 or HPV18-positive...