A5033873390- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Anesthesia and Sedative Agents
- Cytomegalovirus and herpesvirus research
- Ocular Diseases and Behçet’s Syndrome
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Intensive Care Unit Cognitive Disorders
- Iron Metabolism and Disorders
- Trace Elements in Health
- IL-33, ST2, and ILC Pathways
- Otitis Media and Relapsing Polychondritis
- Calcium signaling and nucleotide metabolism
- Hidradenitis Suppurativa and Treatments
- Genetic Neurodegenerative Diseases
- Hepatitis C virus research
- Allergic Rhinitis and Sensitization
- Probiotics and Fermented Foods
- Enterobacteriaceae and Cronobacter Research
Inserm
2003-2025
Université de Strasbourg
2010-2025
Hôpital Civil, Strasbourg
2016-2025
Hôpitaux Universitaires de Strasbourg
2005-2024
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2015-2021
National Research Institute of Brewing
2017-2019
Central Institute for Experimental Animals
2002
Tokai University
2002
Wellcome Sanger Institute
2002
Institut d’Epidémiologie Neurologique et de Neurologie Tropicale
1999
Abstract Background Neurotropism of SARS-CoV-2 and its neurological manifestations have now been confirmed. We aimed at describing delirium symptoms COVID-19 in ICU patients. Methods conducted a bicentric cohort study two French ICUs Strasbourg University Hospital. All the 150 patients referred for acute respiratory distress syndrome due to between March 3 May 5, 2020, were included their admission. Ten (6.7%) excluded because they remained under neuromuscular blockers during entire stay....
Shwachman-Diamond syndrome (SDS) (OMIM #260400) is a rare inherited bone marrow failure (IBMFS) that primarily characterized by neutropenia and exocrine pancreatic insufficiency. Seventy-five to ninety percent of patients have compound heterozygous loss-of-function mutations in the Shwachman-Bodian-Diamond (sbds) gene. Using trio whole-exome sequencing (WES) an sbds-negative SDS family candidate gene additional SBDS-negative cases or molecularly undiagnosed IBMFS cases, we identified 3...
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators this condition have remained elusive. We used a multi-omics analysis combined with artificial intelligence in young patient cohort where comorbidities were excluded at the onset. included 47 “critical” (in intensive care unit under mechanical ventilation) 25 “non-critical” non-critical ward) patients COVID-19 22 healthy individuals....
Non‐conventional major histocompatibility complex class I molecules are involved in a variety of physiological functions, most at the periphery immune system per se. Zinc‐α 2 ‐glycoprotein (ZAG), sole soluble member this superfamily has been implicated cachexia, poorly understood yet life‐threatening, severe wasting syndrome. To further ascertain role ZAG lipid metabolism and perhaps system, we inactivated both alleles by gene targeting mice. Subjecting these deficient animals to standard or...
ABSTRACT Importance Apart from Huntington's disease, little is known of the genetics autosomal dominant chorea associated with dystonia. Here we identify adenylate cyclase 5 ( ADCY5 ) as a likely new causal gene for early‐onset and Observations Whole exome sequencing in three‐generation family affected dystonia identified single de novo mutation—c.2088+1G>A 5' donor splice‐site —segregating disease. This mutation seeming leads to RNA instability therefore haploinsufficiency. Conclusions...
The Nck-associated protein 1–like (NCKAP1L) gene, alternatively called hematopoietic 1 (HEM-1), encodes a lineage–specific regulator of the actin cytoskeleton. Nckap1l-deficient mice have anomalies in lymphocyte development, phagocytosis, and neutrophil migration. Here we report, for first time, NCKAP1L deficiency cases humans. In two unrelated patients Middle Eastern origin, recessive mutations abolishing expression led to immunodeficiency, lymphoproliferation, hyperinflammation with...
The MHC class I chain-related MICA molecule is a stress-induced, highly polymorphic, epithelia-specific, membrane-bound glycoprotein interacting with the activating NK cell receptor NKG2D and/or gut-enriched Vδ1-bearing γδ T cells. We have previously reported presence of transmembrane-encoded short-tandem repeat harboring peculiar allele, A5.1, characterized by frame shift mutation leading to premature intradomain stop codon, thus denying its 42-aa cytoplasmic tail. Given that this most...
ABSTRACT We report the first case of fungemia due to Candida catenulata , a contaminant dairy products. C. was isolated from three blood cultures patient with gastric cancer. The failed respond fluconazole but recovered after treatment switched amphotericin B. In vitro, susceptible B and itraconazole also in dose-dependent manner. likely portal entry digestive tract, as often ate cheese had multiple ulcerations.
AIDS-associated primary central nervous system lymphomas are late events that have an extremely poor prognosis. Despite different hypotheses, the brain localization of these B cell remains enigma. To better define origin and possible role receptor (BCR) in and/or oncogenic transformation, we analyzed V region genes Ig heavy chain expressed by lymphoma cells five randomly selected patients. After amplifying rearranged VHDJH DNA PCR, cloning, sequencing amplified products, observed that: 1)...