A5013128168- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Mass Spectrometry Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Gene expression and cancer classification
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Anesthesia and Pain Management
- Advanced Biosensing Techniques and Applications
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
- Genital Health and Disease
- Cellular Mechanics and Interactions
- Advanced Neuroimaging Techniques and Applications
- Nuclear Structure and Function
- Neuroscience of respiration and sleep
- Acute Lymphoblastic Leukemia research
- HER2/EGFR in Cancer Research
- Immunodeficiency and Autoimmune Disorders
- Nerve Injury and Rehabilitation
Technical University of Munich
2025
Université de Strasbourg
2016-2021
Centre National de la Recherche Scientifique
2016-2021
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021
Institut Pluridisciplinaire Hubert Curien
2017-2019
Protéomique, Réponse Inflammatoire et Spectrométrie de Masse
2017-2019
Zero to Three
2016
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators this condition have remained elusive. We used a multi-omics analysis combined with artificial intelligence in young patient cohort where comorbidities were excluded at the onset. included 47 “critical” (in intensive care unit under mechanical ventilation) 25 “non-critical” non-critical ward) patients COVID-19 22 healthy individuals....
Background: According to the model of glymphatic system, directed flow cerebrospinal fluid (CSF) is a driver waste clearance from brain. In sleep, transport enhanced, but it unclear how affected by anesthesia. Animal research indicates partially opposing effects distinct anesthetics corresponding results in humans are lacking. Thus, this study aims investigate effect sevoflurane anesthesia on CSF humans, both during and after Methods: Using data functional magnetic resonance imaging (fMRI)...
Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well various types of nucleic acids. All translation machinery components require multiple maturation events to be functional. These include post-transcriptional post-translational modification steps methylations are the most frequent among these events. In eukaryotes, Trm112, small (COG2835) conserved in all three domains life, interacts activates four methyltransferases (Bud23, Trm9,...
Significance Microtubule dynamics is tightly regulated during fundamental biological processes such as mitosis, thereby representing a major target for anticancer therapies. To better understand the molecular mechanisms underlying organization of microtubule network, we systematically investigated proteins interacting with EB1, regulator microtubules dynamics. We identified specific isoform myomegalin, which termed “SMYLE,” that assembles macromolecular complex associated centrosome,...
Abstract The prognosis of patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains unsatisfactory and, despite major advances in genomic studies, the biological mechanisms underlying chemoresistance are still poorly understood. We conducted for first time a large-scale differential multi-omics investigation on DLBCL patient’s samples order to identify new biomarkers that could early at risk R/R disease and targets determine chemorefractoriness. compared...
At least 80% of children with cancer live in low- and middle-income countries where the prevalence malnutrition socioeconomic disadvantage is high. We examined relationship between nutritional status (NS), assessed by arm anthropometry, (SES) diagnosed at Unidad Nacional de Oncologia Pediatrica (UNOP) Guatemala over a three-year period.Patients aged 0 to 18 years age January 2015 December 2017 were included. NS was evaluated mid-upper circumference, triceps skin fold thickness, serum albumin...
Sample preparation, typically by in-solution or in-gel approaches, has a strong influence on the accuracy and robustness of quantitative proteomics workflows. The major benefit procedures is their compatibility with detergents (such as SDS) for protein solubilization. However, SDS-PAGE time-consuming approach. Tube-gel (TG) preparation circumvents this drawback it involves directly trapping sample in polyacrylamide gel matrix without electrophoresis. We report here first global label-free...
B-cell receptor (BCR) signaling is crucial for the pathophysiology of most mature lymphomas/leukemias and has emerged as a therapeutic target whose effectiveness remains limited by occurrence mutations. Therefore, deciphering cellular program activated downstream this pathway become paramount importance development innovative therapies. Using an original ex vivo model BCR-induced proliferation chronic lymphocytic leukemia cells, we generated 108 temporal transcriptional proteomic profiles...
Sample preparation for quantitative proteomics is a crucial step to ensure the repeatability and accuracy of results. However, there no universal method compatible with wide variety protein extraction buffers currently used. We have recently demonstrated compatibility tube-gel SDS-based its efficiency label-free by comparing it stacking gel liquid digestion. Here, we investigated alternatives allowing notably proteins in various pH conditions. also explored use photopolymerization extend...
Abstract The etiopathogenesis of severe COVID-19 remains unknown. Indeed given major confounding factors (age and co-morbidities), true drivers this condition have remained elusive. Here, we employ an unprecedented multi-omics analysis, combined with artificial intelligence, in a young patient cohort where co-morbidities been excluded at the onset. established three-tier individuals younger than 50 years without comorbidities. These included 47 “critical” (in ICU under mechanical...