A5057390735- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- vaccines and immunoinformatics approaches
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Breast Cancer Treatment Studies
- Hepatitis C virus research
- PARP inhibition in cancer therapy
- Peripheral Neuropathies and Disorders
- Drug-Induced Adverse Reactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pathogenesis and Treatment of Hiccups
- Cancer Diagnosis and Treatment
- Autoimmune Neurological Disorders and Treatments
- Brain Metastases and Treatment
- Economic and Financial Impacts of Cancer
- Infectious Diseases and Tuberculosis
Institut Gustave Roussy
2019-2025
Pathways Behavioral Services
2024-2025
Université Paris-Saclay
2021-2024
Bicêtre Hospital
2019-2023
Assistance Publique – Hôpitaux de Paris
2016-2023
Université Paris-Sud
2019-2021
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2019
Infectious Disease Models and Innovative Therapies
2019
Inserm
2019
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2019
Although immune checkpoint inhibitors (ICIs), such as anti-PD-1 (programmed cell death 1) or anti-PD-L1 1 ligand 1), have proved effective in treating many cancers, patients receiving ICIs may experience immune-related adverse events (irAEs). Little evidence exists on the safety of resuming these treatments after an irAE.
Chemotherapy associated with Immune Checkpoint Inhibitors is currently the standard of care in several tumor indications. This combination approach improves progression free survival (PFS), overall (OS) and complete pathological response (pCR) cancer types both early metastatic approaches. However, distinct spectrum toxicities between cytotoxic side effects immune related adverse events (irAEs) similar clinical presentations different management strategies remains a challenge daily practice...
Although the global deleterious impact of antibiotics on intestinal microbiota is well known, temporal changes in microbial diversity during and after an antibiotic treatment are still poorly characterized. We used plasma fecal samples collected frequently up to one month from 22 healthy volunteers assigned a 5-day by moxifloxacin ( n = 14) or no intervention 8).
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but frequently cause immune-related adverse events (IrAEs). ICI-induced large vessel vasculitis (LVV) is a rare IrAE, with limited available data. We aimed to describe and compare clinical characteristics evolution of LVV primary LVV. This retrospective, multicentre European study included adult patients who developed after ICI therapy between March 2018 August 2024. Patients were compared matched controls was defined...
We investigated infectious complications and the associated risk factors in 181 patients undergoing T-cell engagers for malignancies. Infections were primarily observed with hematological diseases or heavily pre-treated. Mortality due to was 2.8%. Concomitant medications corticosteroids tocilizumab did not significantly impact incidence of infections.
Abstract Neurological immune-related adverse events are complications of programmed-cell death 1 or ligand immunotherapies that can be life threatening and often lead to anticancer immunotherapy withdrawal. Scant clinical data available integrate the presentation, therapeutic management long-term outcome. All consecutive adult patients treated by immunotherapies, given alone in combination with other treatment, who experienced a neurological event severity grade ≥2 Paris Saclay-University...
Although the metabolic properties of white adipose tissue have been extensively characterized, tissue's immune are now attracting renewed interest. Early experiments in a mouse model suggested that contains high density regulatory T cells (Tregs), and so it was assumed all has an immunosuppressive profile-even though investigation limited to visceral body fat relatively old male mice. This observation also corroborated by frequencies other cell subsets with immunoregulatory properties, such...
Abstract Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine release was...
Background Supportive care (SC) refers to the prevention and management of complications cancer its treatment. While it has long been recognized as an important delivery component, a high proportion patients face unaddressed SC needs, calling for innovative approaches deliver SC. Objective The objective this master protocol is evaluate implementation different integrated proactive pathways across continuum in our institution (Gustave Roussy, Villejuif, France). Pathways studied may occur...
Aging | doi:10.18632/aging.203525. Mélanie Bourgin, Lisa Derosa, Carolina Alves Costa Silva, Anne-Gaëlle Goubet, Agathe Dubuisson, François-Xavier Danlos, Claudia Grajeda-Iglesias, Luigi Cerbone, Arthur Geraud, Ariane Laparra, Fanny Aprahamian, Nitharsshini Nirmalathasan, Frank Madeo, Laurence Zitvogel, Guido Kroemer, Sylvère Durand
Background: Behçet’s disease (BD) is a rare form of vasculitis involving both veins and arteries all calibers. Psychological symptoms cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwent psychometric evaluation with auto- (SCL-90-R Modified Fatigue Index) hetero-questionnaires (MINI). A standardized test battery assessed dysfunction. Data were correlated activity as well quality life...
Immune checkpoint inhibitors (ICI) have improved outcomes in patients with eTNBC. However, irAEs are a major concern clinical practice. 18F-FDG PET/CT scan is routinely performed for initial staging before neoadjuvant treatment immunotherapy and chemotherapy (NACT-IO). This study aims to evaluate whether FDG-PET features could predict the occurrence of irAE from NACT-IO We conducted single-center retrospective on eTNBC treated NACT pembrolizumab, between April 2022 2023. Adverse events were...