A5044298720- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Ginger and Zingiberaceae research
- Acute Myeloid Leukemia Research
- Dietary Effects on Health
- Radiomics and Machine Learning in Medical Imaging
- Parathyroid Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Piperaceae Chemical and Biological Studies
- Toxin Mechanisms and Immunotoxins
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Tea Polyphenols and Effects
- Virus-based gene therapy research
- Nutrition and Health in Aging
- Histone Deacetylase Inhibitors Research
- Thyroid and Parathyroid Surgery
- Inflammatory Biomarkers in Disease Prognosis
- Helicobacter pylori-related gastroenterology studies
- ECG Monitoring and Analysis
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Oral health in cancer treatment
- Protein Degradation and Inhibitors
- EEG and Brain-Computer Interfaces
Université de Montréal
2022-2024
Montreal Heart Institute
2024
Mila - Quebec Artificial Intelligence Institute
2024
Institute for Research in Immunology and Cancer
2022-2023
Centre Hospitalier de l’Université de Montréal
2021-2022
McGill University Health Centre
2018-2022
Several approaches to manipulate the gut microbiome for improving activity of cancer immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral supplementation with polyphenol-rich berry camu-camu (CC; Myrciaria dubia) in mice shifted microbial composition, which translated into antitumor and a stronger anti-PD-1 response. We identified castalagin, an ellagitannin, as active compound CC. Oral administration castalagin enriched bacteria associated efficient...
Cancer cachexia exerts a negative clinical influence on patients with advanced non-small-cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICI). The prognostic impact of body weight change during ICI treatment remains unknown. gut microbiota (GM) is key contributor to the response therapy in patients. However, association between and GM their ICIs unexplored. This study examined composition assessed outcomes NSCLC ICIs. In this observational, prospective study, which included...
The 12-lead electrocardiogram (ECG) remains a cornerstone of cardiac diagnostics, yet existing artificial intelligence (AI) solutions for automated interpretation often lack generalizability, remain closed-source, and are primarily trained using supervised learning, limiting their adaptability across diverse clinical settings. To address these challenges, we developed compared two open-source foundational ECG models: DeepECG-SSL, self-supervised learning model, DeepECG-SL, model. Both models...
The t(6;9)(p22.3;q34.1) translocation/DEK::NUP214 fusion protein defines a distinct subgroup of younger AML patients classified as separate disease entity by the World Health Organization. DEK is nuclear factor with multifunctional roles, including gene regulation, while its partner, NUP214, plays pivotal role in export interacting transport receptors such XPO1. However, precise mechanism which DEK::NUP214 drives leukemia remains unclear. A comprehensive multi-omics comparison 57 primary...
Abstract The t(6;9)(p22.3;q34.1) translocation/DEK::NUP214 fusion protein defines a distinct subgroup of younger AML patients classified as separate disease entity by the World Health Organization. DEK is nuclear factor with multifunctional roles, including gene regulation, while its partner, NUP214, plays pivotal role in export interacting transport receptors such XPO1. However, precise mechanism which DEK::NUP214 drives leukemia remains unclear. A comprehensive multi-omics comparison 57...
The microbiome is now regarded as one of the hallmarks cancer and several strategies to modify gut microbiota improve immune checkpoint inhibitor (ICI) activity are being evaluated in clinical trials. Preliminary data regarding upper gastro-intestinal indicated that
The aim of this study was to analyze variants the gene glial cells missing-2 (GCM2), encoding a parathyroid cell-specific transcription factor, in familial hypoparathyroidism and isolated hyperparathyroidism (FIHP) without with carcinoma.We characterized 2 families 19 FIHP which we examined mechanism action GCM2 variants.Leukocyte DNA hypoparathyroid individuals Sanger sequenced for CASR, PTH, GNA11 mutations. hyperparathyroid underwent MEN1, CDKN1B, CDC73, RET sequencing. actions identified...
ContextAutosomal dominant hypocalcemia type 1 (ADH1) is caused by heterozygous activating mutations in the calcium-sensing receptor gene (CASR). Whether polymorphisms that are benign state pathologically alter function homozygous unknown.
9050 Background: Host-related inflammatory biomarkers and gut microbiome are two major prognostic factors for non-small cell lung cancer (NSCLC) patients (pts) treated with immune checkpoint inhibitors (ICI). In this study, we aimed to assess an association between the Lung Immune Prognostic Index (LIPI) composition on ICI outcomes in independent cohorts of NSCLC pts. Methods: We included 205 advanced (monotherapy or combination chemotherapy) from cohorts. Metagenomics profiling was...
9036 Background: Despite immune-checkpoint inhibitors (ICI) achieving high response rates in patients (pts) with advanced non-small cell lung cancer (NSCLC), immune-related adverse events (irAE) remain an important therapeutic hurdle. The gut microbiome represents a novel prognostic marker of ICI and early clinical evidence suggests that the may also regulate development irAE. We aimed to assess association between irAE composition NSCLC pts amenable ICI. Methods: In this study, we enrolled...
Abstract The accelerating use of combined immune checkpoint inhibitors (ICI; anti-PD-1 plus anti-CTLA-4 antibodies) enhanced therapeutic responses in various cancers while significantly increasing immune-related adverse events (irAE). mechanism involved the occurrence immune-mediated diarrhea and colitis (IMDC) its potential implication on ICI efficacy remain unclear. gut microbiome is progressively recognized as a key biomarker preliminary results suggest association with irAE. However,...
<div>Abstract<p>Several approaches to manipulate the gut microbiome for improving activity of cancer immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral supplementation with polyphenol-rich berry camu-camu (CC; <i>Myrciaria dubia</i>) in mice shifted microbial composition, which translated into antitumor and a stronger anti–PD-1 response. We identified castalagin, an ellagitannin, as active compound CC. Oral administration...
<div>Abstract<p>Several approaches to manipulate the gut microbiome for improving activity of cancer immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral supplementation with polyphenol-rich berry camu-camu (CC; <i>Myrciaria dubia</i>) in mice shifted microbial composition, which translated into antitumor and a stronger anti–PD-1 response. We identified castalagin, an ellagitannin, as active compound CC. Oral administration...
Supplementary Figure from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota
Supplementary Figure from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota