A5079487846- Gut microbiota and health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Hydrolysis and Bioactive Peptides
- Fatty Acid Research and Health
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Nutrition, Genetics, and Disease
- Phytochemicals and Antioxidant Activities
- Nutritional Studies and Diet
- Plant-Derived Bioactive Compounds
- Liver Disease Diagnosis and Treatment
- Ginger and Zingiberaceae research
- Probiotics and Fermented Foods
- Muscle metabolism and nutrition
- Antioxidant Activity and Oxidative Stress
- Natural Antidiabetic Agents Studies
- Pancreatic function and diabetes
- Gastrointestinal motility and disorders
- Aquaculture Nutrition and Growth
- Clostridium difficile and Clostridium perfringens research
- Regulation of Appetite and Obesity
Université Laval
2016-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2014-2024
Montreal Heart Institute
2010-2024
University of Toronto
2022
Faculty (United Kingdom)
2016-2021
Laval Mayenne Technopole
2020
Lung Institute
2014-2016
Université du Québec à Montréal
2008
<h3>Objective</h3> The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure conventional treatments to curb these diseases. gut microbiota has been put forward as a key player in pathophysiology diet-induced T2D. Importantly, cranberry (<i>Vaccinium macrocarpon</i> Aiton) is associated with number beneficial health effects. We aimed investigate metabolic impact extract (CE) on high fat/high sucrose (HFHS)-fed mice determine whether its consequent antidiabetic...
Objective The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu ( Myrciaria dubia ) an Amazonian fruit a unique phytochemical profile, strong antioxidant potential purported anti-inflammatory potential. Design By using metabolic tests coupled 16S rRNA gene-based taxonomic profiling faecal microbial transplantation (FMT), we have assessed effect crude extract (CC) on obesity immunometabolic disorders high...
Several approaches to manipulate the gut microbiome for improving activity of cancer immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral supplementation with polyphenol-rich berry camu-camu (CC; Myrciaria dubia) in mice shifted microbial composition, which translated into antitumor and a stronger anti-PD-1 response. We identified castalagin, an ellagitannin, as active compound CC. Oral administration castalagin enriched bacteria associated efficient...
Previous studies have reported that polyphenol-rich extracts from various sources can prevent obesity and associated gastro-hepatic metabolic disorders in diet-induced obese (DIO) mice. However, whether such reverse obesity-linked alterations remains unknown. In the present study, we aimed to investigate potential of a extract cranberry (CE) DIO-mice.Mice were pre-fed either Chow or High Fat-High Sucrose (HFHS) diet for 13 weeks induce then treated with CE (200 mg/kg, + CE, HFHS CE) vehicle...
Abstract Plant-derived foods rich in polyphenols are associated with several cardiometabolic health benefits, such as reduced postprandial hyperglycaemia. However, their impact on whole-body insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp technique remains under-studied. We aimed to determine effects of strawberry and cranberry (SCP) sensitivity, glucose tolerance, secretion, lipid profile, inflammation oxidative stress markers free-living insulin-resistant overweight or...
The gut and its bacterial colonizers are now well characterized as key players in whole-body metabolism, opening new avenues of research generating great expectation for treatments against obesity cardiometabolic complications. As diet is the main environmental factor affecting microbiota, it has been suggested that fruits vegetables, whose consumption strongly associated with a healthy lifestyle, may carry phytochemicals could help maintain intestinal homeostasis metabolic health. We...
Berries are rich in polyphenols and plant cell wall polysaccharides (fibres), including cellulose, hemicellulose, arabinans arabino-xyloglucans pectin. Most of fibres known to be poorly absorbed the small intestine reach colon where they interact with gut microbiota, conferring health benefits host. This study assessed contribution polyphenol-rich whole cranberry blueberry fruit powders (CP BP), that their fibrous fractions (CF BF) on modulating microbial functional profile influencing...
Blueberries are a rich source of polyphenols, widely studied for the prevention or attenuation metabolic diseases. However, health contribution and mechanisms action polyphenols depend on their type structure. Here, we evaluated effects wild blueberry polyphenolic extract (WBE) (Vaccinium angustifolium Aiton) cardiometabolic parameters, gut microbiota composition epithelium histology high-fat high-sucrose (HFHS) diet-induced obese mice determined which constitutive fractions (BPF) was...
Blueberry consumption can prevent obesity-linked metabolic diseases, and it has been proposed that the polyphenol content of blueberries may contribute to these effects. Polyphenols have shown favorably impact health, but role specific classes whether gut microbiota is linked effects remain unclear. We aimed evaluate whole blueberry powder polyphenols on development obesity insulin resistance determine potential microbes in by using fecal transplantation (FMT). Sixty-eight C57BL/6 male mice...
The consumption of plant-based bioactive compounds modulates the gut microbiota and interacts with innate adaptive immune responses associated metabolic disorders. present study aimed to evaluate effect cranberry polyphenols (CP), rich in flavonoids, agavins (AG), a highly branched agave-derived neo-fructans, on cardiometabolic response, composition, endotoxemia, mucosal immunomodulation C57BL6 male mice fed an obesogenic high-fat high-sucrose (HFHS) diet for 9 weeks. Interestingly,...
AMP-activated protein kinase (AMPK), an energy-sensing enzyme that is activated in response to cellular stress, a critical signaling molecule for the regulation of multiple metabolic processes. AMPK has recently emerged as attractive novel target treatment obesity and type 2 diabetes because its activation increases fatty acid oxidation improves glucose homeostasis. Here we show pharmacological by insulin-sensitizing drugs markedly inhibits inducible nitric-oxide synthase (iNOS),...
Obesity and obesity-related disorders, such as type 2 diabetes have been progressively increasing worldwide treatments failed to counteract their progression. Growing evidence demonstrated that gut microbiota is associated with the incidence of these pathologies. Hence, identification new nutritional compounds, able improve health through a modulation microbiota, gaining interest. In this context, aim study was investigate gut-driving effects rhubarb extract in context diet-induced obesity...
Endocrine effects of adipose-derived adiponectin on skeletal muscle have been shown to account, at least in part, for the anti-diabetic this adipokine. Recently, concept myokines has gained credence, and potential produce suggested. Here we demonstrated an increased level mRNA protein expression as well secretion response rosiglitazone treatment L6 cells. This correlated with ability enhance insulin sensitivity stimulation kinase B (Akt) phosphorylation glucose transport; also corrected...
Background It is believed that the endotoxin lipopolysaccharide (LPS) implicated in metabolic perturbations associated with both sepsis and obesity (metabolic endotoxemia). Here we examined role of inducible nitric oxide synthase (iNOS) skeletal muscle insulin resistance using LPS challenge rats mice as vivo models endotoxemia. Methodology/Principal Findings Pharmacological (aminoguanidine) genetic strategies (iNOS−/− mice) were used to counter iNOS induction vivo. In vitro studies...
Given the growing evidence that gut dysfunction, including changes in microbiota composition, plays a critical role development of inflammation and metabolic diseases, identification novel probiotic bacteria with immunometabolic properties has recently attracted more attention. Herein, bacterial strains were first isolated from dairy products human feces then screened vitro for their immunomodulatory activity. Five selected further analyzed vivo, using mouse model diet-induced obesity....
Proinflammatory cytokines are important factors in the regulation of diverse aspects skeletal muscle function; however, cytokine receptors mediating these functions uncharacterized. Binding kinetics (dissociation constant = 39+/-4.7 x 10(-9) M, maximal binding 3.5+/-0.23 10(-12) mol/mg membrane protein) tumor necrosis factor (TNF) were obtained. Skeletal was found to express mRNAs encoding interleukin-1 type I and II receptors, interleukin-6 receptor (IL-6R), interferon-gamma by RT-PCR, but...